TRANSDERMAL DELIVERY OF DEXAMETHASONE AND PROMETHAZINE
Relief or prophylaxis from nausea and/or emesis are provided by transdermal compositions comprising dexamethasone and promethazine. The transdermal compositions are in the form of transdermal solutions and/or suspensions, such as lotions, pastes, gels, ointments or transdermal patches.
1 . A composition for transdermal drug delivery, comprising dexamethasone and promethazine, or a pharmaceutically acceptable salt thereof.
2 . The composition of claim 1 in unit dosage form.
3 . The composition of claim 1 , comprising an antiemetic amount of the combination of dexamethasone and promethazine, or a pharmaceutically acceptable salt thereof.
4 . The composition of claim 1 , further comprising a skin penetration enhancer.
5 . A composition for transdermal drug delivery, comprising dexamethasone and promethazine, or a pharmaceutically acceptable salt thereof, in admixture with a pharmaceutically acceptable transdermal delivery vehicle.
6 . The composition of claim 5 in unit dosage form.
7 . The composition of claim 5 , comprising an antiemetic amount of the combination of dexamethasone and promethazine, or a pharmaceutically acceptable salt thereof.
8 . The composition of claim 5 , comprising a skin penetration enhancer.
9 . A composition for transdermal drug delivery, comprising dexamethasone and promethazine, or a pharmaceutically acceptable salt thereof, in admixture with a pharmaceutically acceptable transdermal delivery excipient, adjuvant or penetration enhancer.
10 . The composition of claim 9 in unit dosage form.
11 . The composition of claim 9 , comprising an antiemetic amount of the combination of dexamethasone and promethazine.
12 . A transdermal patch for the treatment or prevention of nausea and/or emesis in a subject, comprising a therapeutically effective amount of dexamethasone and promethazine, or a pharmaceutically acceptable salt thereof.
13 . The transdermal patch of claim 12 , wherein the patch is a single layer medicine in adhesive patch.
14 . The transdermal patch of claim 12 , wherein the patch is a multi-layer medicine in adhesive patch.
15 . The transdermal patch of claim 12 , wherein the patch is a reservoir patch.
16 . The transdermal patch of claim 12 , wherein the patch is a matrix patch.
17 . The transdermal patch of claim 12 , wherein the patch is a microneedle patch.
18 . The transdermal patch of claim 12 , wherein the patch is an iontophoretic patch.
19 . The transdermal patch as in any one of claims 12 - 18 , further comprising a skin penetration enhancer.
20 . A method of treating or preventing nausea and/or emesis in a subject, comprising transdermally administering to the subject a therapeutically effective amount of a combination of dexamethasone and promethazine or a pharmaceutically acceptable salt thereof.
21 . The method of claim 20 , wherein the therapeutically effective amount of dexamethasone and promethazine is administered in admixture with a topically-applied vehicle.
22 . The method of claim 20 , wherein the therapeutically effective amount of dexamethasone and promethazine is administered as a transdermal patch.
23 . The method of claim 22 , wherein the transdermal patch is adapted for sustained release.
24 . A kit comprising an antiemetically effective combination of dexamethasone and promethazine for transdermal administration.
25 . The kit of claim 24 , comprising a first patch comprising dexamethasone.
26 . The kit of claim 25 , comprising a second patch comprising promethazine.
27 . The kit of claim 26 , wherein the second patch is substantially free of dexamethasone.
28 . The kit of claim 26 , wherein the first patch is substantially free of promethazine.
29 . The kit of claim 24 , comprising a single patch comprising the combination of dexamethasone and promethazine.
30 . The kit as in any one of claims 24 - 29 , further comprising instructions for the transdermal, antiemetic use of the antiemetically effective combination of dexamethasone and promethazine.