DIRS1 polypeptides
View Patent ↗Nucleic acids encoding mammalian, e.g., primate or rodent receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
1. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO: 2.
2. The polypeptide of claim 1 , which is produced by a recombinant host cell.
3. The polypeptide of claim 1 , which comprises a heterologous protein.
4. The polypeptide of claim 3 , wherein the heterologous protein is selected from the group consisting of a FLAG-tag, a His-6 tag, an Ig, luciferase, glutathione-S-transferase (GST), bacterial β-galactosidase, trpE, β-lactamase, alpha amylase, alcohol dehydrogenase, and yeast alpha mating factor.
5. The polypeptide of claim 1 , which is glycosylated.
6. An isolated polypeptide comprising amino acids 30-311 of SEQ ID NO: 2.
7. The polypeptide of claim 6 , which is produced by a recombinant host cell.
8. The polypeptide of claim 6 , which comprises a heterologous protein.
9. The polypeptide of claim 8 , wherein the heterologous protein is selected from the group consisting of a FLAG-tag, a His-6 tag, an Ig, luciferase, glutathione-S-transferase (GST), bacterial β-galactosidase, trpE, β-lactamase, alpha amylase, alcohol dehydrogenase, and yeast alpha mating factor.
10. The polypeptide of claim 6 , which is glycosylated.