Treating cancer using electromagnetic fields in combination with photodynamic therapy
View Patent ↗A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is induced in the region. The field causes the light generating circuit to generate light, which activates the photosensitizer; and at certain field strengths and frequencies, the field itself has a beneficial effect. The beneficial effects of the field and the activated photosensitizer are thereby obtained simultaneously.
1. A method of simultaneously exposing a target region within a subject's body to light and an electric field, the method comprising the steps of:
embedding, within the subject, a light-emitting diode having a first terminal and a second terminal, wherein the light-emitting diode is positioned so as to illuminate the target region, and wherein the first terminal and the second terminal of the light-emitting diode are spaced apart by a distance D;
administering, to the subject, a photosensitizer that accumulates in tissue at the target region, wherein the photosensitizer is activated by a wavelength of light that is emitted by the light-emitting diode; and
capacitively coupling, into the target region, an AC electric field having an amplitude and orientation that causes an AC voltage gradient to appear between the first terminal and the second terminal of the light-emitting diode, wherein the AC voltage gradient is large enough to activate the light-emitting diode and cause the light-emitting diode to emit light.
2. The method of claim 1 , wherein the distance D is between 0.5 and 5 cm and the AC electric field has a field strength between 1 and 10 V/cm.
3. The method of claim 1 , wherein the AC electric field has a frequency between 100 kHz and 300 kHz.
4. The method of claim 1 , wherein the photosensitizer damages cancer cells when it is activated by illumination.
5. The method of claim 1 , wherein the distance D is between 0.5 and 5 cm, the AC electric field has a field strength between 1 and 10 V/cm, the AC electric field has a frequency between 100 kHz and 300 kHz, and the photosensitizer damages cancer cells when it is activated by illumination.
6. The method of claim 5 , wherein the target region comprises a tumor.