Dietary Supplement For Eye Health
Nutritional supplements for eye health comprising: an anti-oxidant component; an anti-inflammatory component; and an anti-angiogenic component. The supplements inhibit development and progression of a range of retinal diseases and degenerations, particularly AMD and diabetic eye disease, diabetic retinopathy and diabetic macular edema. The supplements include tocotrienol and green tea extract.
1 . A nutritional supplement to aid eye health comprising, in combination,
an anti-oxidant component;
an anti-inflammatory component; and
an anti-angiogenic component.
2 . A method of reducing the risk of eye damage associated with diabetes, comprising administering to a patient in need thereof a nutritional supplement to aid eye health, said nutritional supplement comprising, in combination,
either green tea extract, a tocotrienol or both green tea extract and a tocotrienol;
at least one omega 3 fatty acid; and
vitamin D.
3 . The method of claim 2 wherein the nutritional supplement comprises both green tea extract and a tocotrienol.
4 . The method of claim 3 wherein the nutritional supplement further comprises tocopherol.
5 . The method of claim 2 in which the supplement comprises green tea.
6 . The method of claim 2 in which the supplement comprises a tocotrienol having the following formula,
Where R1 R2 and R3 are defined below
Type
R1
R2
R3
α Tocotrienol
Me
Me
Me
β Tocotrienol
Me
H
Me
γ Tocotrienol
Me
Me
H
Δ Tocotrienol
Me
H
H
7 . The method of claim 2 or claim 22 in which the supplement includes at least one catechin.
8 . The supplement of claim 7 in which the catechin is epigallocatechin gallate (EGCG), catechin-3 gallate (CG), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC), or a combination of two or more of these compounds.
9 . The method of claim 2 or claim 22 in which the supplement inhibits endothelial cell proliferation with IC 50 less than 2 μM.
10 . The method of claim 2 or claim 22 in which in which the supplement further comprises vitamin C.
11 . The method of claim 2 in which the supplement further comprises lutein, zeaxanthin or both.
12 . (canceled)
13 . (canceled)
14 . (canceled)
15 . The method of claim 4 in which the supplement comprises d-alpha-tocopherol in a dosage below 400 IU.
16 . The method of claim 2 or claim 22 in which the supplement comprises zinc present in a dosage below 16 mg.
17 . The method of claim 2 or claim 22 wherein the supplement comprises docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) or a combination of EPA and DHA.
18 . (canceled)
19 . The method of claim 16 in which the supplement further comprises copper.
20 . A composition comprising at least one soft gel cap and at least one tablet, said soft gel cap or soft gel caps comprising vitamin D and tocotrienol, and said tablet comprising green tea extract and lutein, said soft gel cap or soft gel caps and said tablet being packaged together in a single package.
21 . (canceled)
22 . A method of reducing the risk of eye damage associated with diabetes, comprising administering to a patient in need thereof a supplement in an amount effective to treat or reduce eye damage, said supplement comprising at least one soft gel capsule or soft gel capsules and at least one tablet, said soft gel capsule or soft gel capsules comprising vitamin D and tocotrienol, and said tablet comprising green tea extract and lutein, said soft gel capsule or soft gel capsules and said tablet being packaged together in a single package.
23 . The method of claim 2 or claim 22 in which the supplement comprises the following components in the following dosages:
Vitamin D between 2000 IU and 5000 IU;
Green tea extract in an amount providing 40 to 350 mg of EGCG; and
Palm-oil based tocotrienol at 25-60 mg or Tocomin SuproBio™ tocotrienol at 10-24 mg.
24 . The method of claim 2 or claim 22 in which the patient has been diagnosed with diabetes.
25 . The method of claim 22 in which the supplement further comprises zeaxanthin.