IP Library › Granted Patent US 8,263,070
Granted Patent B2
US 8,263,070 · App. 12/045,153 · Granted Sep 11, 2012

Methods of modulating CD200 receptors

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Quick Facts
Patent No.
US 8,263,070
App. No.
12/045,153
Granted
Sep 11, 2012
Kind
B2
Abstract

Provided are methods for modulating activity of the immune system using agonists or antagonists of a CD200 receptor. Also provided are methods of treatment and diagnosis of immune disorders.

Claims (7)

1. A method of treating allergic rhinitis comprising, contacting a mast cell with an agonist antibody that specifically binds to CD200Ra (SEQ ID NO:2) or an antigenic fragment of CD200Ra (SEQ ID NO:2), wherein said agonist antibody inhibits degranulation by the mast cell.

2. The method of claim 1 , wherein the antibody is selected from the group consisting of a humanized antibody, a monoclonal antibody and a polyclonal antibody.

3. The method of claim 2 , wherein the antibody is a humanized antibody.

4. The method of claim 1 , further comprising administering a second agent.

5. The method of claim 4 , wherein the second agent is selected from the group consisting of an immunosuppressive agent and an anti-inflammatory agent.

6. The method of claim 5 , wherein the second agent is an anti-inflammatory agent.

7. The method of claim 6 , wherein the anti-inflammatory agent is a steroid.

Assignments (1)
CHANGE OF NAME Recorded Aug 30, 2012
From: SCHERING CORPORATION
To: MERCK SHARP & DOHME CORP.
Reel/Frame 028884/0151 →