COMBINATION OF A NARCOTIC AND NON-NARCOTIC ANALGESIC
The present invention is directed to a formulation comprising a narcotic analgesic and a non-narcotic analgesic, methods of use and methods of preparing thereof.
1 . A formulation comprising a narcotic analgesic and a non-narcotic analgesic.
2 . A formulation according to claim 1 wherein said narcotic analgesic is contained in particles and said non-narcotic analgesic is separately contained in separate particles.
3 . A formulation according to claim 2 wherein said particles are modified release particles.
4 . A formulation according to claim 3 wherein said particles comprising a non-narcotic analgesic release said non-narcotic analgesic such that the duration of action of said non-narcotic analgesic matches that of said narcotic analgesic.
5 . A formulation according to claim 4 wherein said particles comprising a non-narcotic analgesic are modified release particles.
6 . A formulation according to claim 3 wherein said particles comprising a narcotic analgesic release said narcotic analgesic such that the duration of action of said narcotic analgesic matches that of said non-narcotic analgesic.
7 . A formulation according to claim 6 wherein said particles comprising a narcotic analgesic are modified release particles.
8 . A method for the treatment of pain comprising administering a therapeutically effective amount of a formulation according to claim 1 .
9 . A method for preparing a formulation which is useful in the treatment of pain comprising the step of mixing a narcotic analgesic and a non-narcotic analgesic.