PREVENTING OR REDUCING OXIDATIVE STRESS OR OXIDATIVE CELL INJURY
A water-soluble cellulose derivative is useful for preventing or reducing oxidative stress or oxidative cell injury in tissues of an animal and in particular for regulating Stearoyl-CoA Desaturase-1 gene expression and/or ATPF1 gene expression in non-adipose tissues of the animal.
1 . A method of regulating the expression of a gene related to fat metabolism of tissues of an animal, which method comprises the step of administering to the animal an effective amount of a water-soluble cellulose derivative.
2 . The method of claim 1 wherein the expression of a gene related to the fat metabolism of non-adipose tissues is regulated.
3 . The method of claim 1 wherein the expression of a gene for the conversion of saturated fatty acids to monounsaturated fatty acids is regulated.
4 - 5 . (canceled)
6 . The method of claim 1 wherein the animal is a mammal.
7 . The method of claim 1 wherein the cellulose derivative is a water-soluble C 1 -C 3 -alkyl cellulose, a water-soluble C 1 -C 3 -alkyl hydroxy-C 1-3 -alkyl cellulose, a water-soluble hydroxy-C 1-3 -alkyl cellulose, a water-soluble mixed hydroxy-C 1 -C 3 -alkyl cellulose, or a water-soluble mixed C 1 -C 3 -alkyl cellulose.
8 . The method of claim 1 wherein from 10 to 300 milligrams of water-soluble cellulose derivative per pound of mammal body weight is administered per day in the form of a pharmaceutical composition, food or food supplement.
9 . A method of regulating Stearoyl-CoA Desaturase-1 gene expression in tissues of an animal, which method comprises the step of administering to the animal an effective amount of a water-soluble cellulose derivative.
10 . The method of claim 9 wherein Stearoyl-CoA Desaturase-1 gene expression in non-adipose tissues of an animal is reduced.
11 . The method of claim 9 wherein Stearoyl-CoA Desaturase-1 gene expression in non-adipose tissues of a mammal is reduced.
12 . The method of claim 11 wherein Stearoyl-CoA Desaturase-1 gene in the liver, pancreas, lungs, kidneys, brain, stomach or in muscles of a mammal is reduced.
13 . The method of claim 9 wherein the cellulose derivative is a water-soluble C 1 -C 3 -alkyl cellulose, a water-soluble C 1 -C 3 -alkyl hydroxy-C 1-3 -alkyl cellulose, a water-soluble hydroxy-C 1-3 -alkyl cellulose, a water-soluble mixed hydroxy-C 1 -C 3 -alkyl cellulose, or a water-soluble mixed C 1 -C 3 -alkyl cellulose.
14 . The method of claim 9 wherein from 10 to 300 milligrams of water-soluble cellulose derivative per pound of mammal body weight is administered per day in the form of a pharmaceutical composition, food or food supplement.
15 - 19 . (canceled)
20 . A method of preventing or treating a disease of an organ of an animal caused or facilitated by Stearoyl-CoA Desaturase-1 gene expression, which method comprises the step of administering to the animal an effective amount of a water-soluble cellulose derivative.
21 . The method of claim 20 wherein mitochondrial or metabolic diseases are prevented or treated.
22 . The method of claim 20 wherein said animal is a human being.
23 - 41 . (canceled)