Aminomethyl azaadamantane derivatives and methods of use thereof
View Patent ↗The invention relates to compounds that are substituted aminomethyl azaadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.
1. A compound of formula (I)
wherein
R 1 is hydrogen;
R 2 is —C(O)-A; and
A is heteroaryl, monocyclic heterocycle, benzopyranyl, benzothiopyranyl, 2,3- dihydrobenzofuranyl, 2,3-dihydrobenzothienyl, 2,3-dihydro-1H-indolyl or tricyclic heterocycle;
or a pharmaceutically acceptable salt or amide thereof.
2. The compound of claim 1 , wherein the compound is selected from the group consisting of
N-[(4r)-1-azatricyclo[3.3.1.1 3,7 ]dec-4-ylmethyl]-5-chloro-1H-indole-2-carboxamide;
N-[(4s)-1-azatricyclo[3.3.1.1 3,7 ]dec-4-ylmethyl]-5-chloro-1H-indole-2-carboxamide;
N-[(4s)-1-azatricyclo[3.3.1.1 3,7 ]dec-4-ylmethyl]-5-fluoro-1H-indole-2-carboxamide;
N-[(4r)-1-azatricyclo[3.3.1.1 3,7 ]dec-4-ylmethyl]-1H-indole-5-carboxamide; and
N-[(4s)-1-azatricyclo[3.3.1.1 3,7 ]dec-4-ylmethyl]-1H-indole-5-carboxamide;
or a pharmaceutically acceptable salt or amide thereof.
3. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt or amide thereof, in combination with one or more pharmaceutically acceptable carriers.
4. The pharmaceutical composition of claim 3 further comprising one or more atypical antipsychotics.