Analyte sensor
Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
1. A continuous analyte sensor system, comprising:
a continuous analyte sensor configured for exposure to a circulatory system of a host and configured to generate a signal associated with an in vivo analyte concentration when the sensor is exposed to a sample of the host; and
sensor electronics configured to process the signal, wherein the sensor electronics comprise a fail-safe module configured to detect a malfunction of the system, wherein the fail-safe module is configured to perform a steady state analysis and a transient analysis of the signal and to evaluate a relationship between the stead state analysis and the transient analysis.
2. The system of claim 1 , wherein the malfunction comprises an electrical malfunction.
3. The system of claim 2 , wherein the electrical malfunction comprises a short circuit.
4. The system of claim 2 , wherein the electrical malfunction is associated with at least one of start-up or sensor break-in.
5. The system of claim 1 , wherein the malfunction comprises a fluidics malfunction.
6. The system of claim 5 , further comprising a flow control system in fluid communication with the sensor, wherein the system is configured to contact at least a portion of the sensor with a sample of the circulatory system, wherein the fluidics malfunction comprises a malfunction of the flow control system.
7. The system of claim 6 , wherein the malfunction of the flow control system comprises at least one of a washing malfunction, a sample collection malfunction, a constriction of a component of the flow control system, or a blood clotting on a portion of the sensor.
8. The system of claim 6 , wherein the flow control system comprises a vascular access device comprising a lumen, and at least a portion of the analyte sensor is configured to reside within the lumen.
9. The system of claim 6 , wherein the flow control system comprises a vascular access device and the analyte sensor is integrally formed with the vascular access device.
10. The system of claim 6 , wherein the flow control system is configured to deliver a reference solution into the vascular access device.
11. The system of claim 1 , wherein the malfunction comprises a sensor malfunction.
12. The system of claim 11 , wherein the sensor malfunction comprises at least one of noise on the signal, drift of a sensitivity, drift of a baseline of the sensor, a broken component of the sensor, blood clotting on a portion of the sensor, or cross-talk.
13. The system of claim 1 , wherein the fail-safe module is further configured to perform a waveform analysis of the signal.
14. The system of claim 1 , wherein the fail-safe module is further configured to provide at least one of an alert, an alarm or an instruction.
15. The system of claim 14 , wherein the fail-safe module is further configured to evaluate a detected malfunction against a criterion.
16. The system of claim 1 , wherein the analyte is glucose.
17. A continuous analyte sensor system, comprising:
a continuous analyte sensor configured for exposure to a circulatory system of a host and configured to generate a signal associated with a in vivo analyte concentration when the sensor is implanted in the host; and
sensor electronics configured to process the signal, wherein the sensor electronics comprise a fail-safe module configured to detect a malfunction of the system, wherein the fail-safe module is configured to perform a stead state analysis and a transient analysis of the signal and to evaluate a relationship between the steady state analysis and the transient analysis.