IP Library › Granted Patent US 8,147,873
Granted Patent B2
US 8,147,873 · App. 12/055,457 · Granted Apr 3, 2012

Methods and compositions for treatment of ion imbalances

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Quick Facts
Patent No.
US 8,147,873
App. No.
12/055,457
Granted
Apr 3, 2012
Kind
B2
Abstract

The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.

Claims (4)

1. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a cation exchange, crosslinked alpha-fluoroacrylic acid polymer or a salt thereof, wherein the alpha-fluoroacrylic acid polymer is crosslinked with divinylbenzene and is in bead form.

2. The pharmaceutical composition of claim 1 suitable for oral or intestinal administration.

3. The pharmaceutical composition of claim 2 suitable for oral administration.

4. The pharmaceutical composition of claim 2 suitable for intestinal administration.

Assignments (8)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 30, 2019
From: RELYPSA, INC.
To: VIFOR (INTERNATIONAL) LTD.
Reel/Frame 049899/0058 →
RELEASE OF SECURITY INTEREST Recorded Sep 2, 2016
From: CANTOR FITZGERALD SECURITIES
To: RELYPSA, INC.
Reel/Frame 039621/0142 →
SECURITY INTEREST Recorded Apr 27, 2016
From: RELYPSA, INC.
To: CANTOR FITZGERALD SECURITIES
Reel/Frame 038394/0034 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNORS ROBERT ALPERN, JERRY BUYSSE, HAN TING CHANG, DOMINIQUE CHARMOT, MICHAEL JAMES COPE, JOHN FORDTRAN, AND GERRIT KLAERNER PREVIOUSLY RECORDED ON REEL 027820 FRAME 0053. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNOR SHOULD ONLY BE DOMINIQUE CHARMOT. Recorded Mar 22, 2012
From: CHARMOT, DOMINIQUE
To: SYMYX THERAPEUTICS, INC.
Reel/Frame 027911/0600 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 7, 2012
From: LIU, MINGJUN
To: ILYPSA, INC.
Reel/Frame 027820/0268 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 7, 2012
From: ILYPSA, INC.
To: RELYPSA, INC.
Reel/Frame 027820/0314 →
CHANGE OF NAME Recorded Mar 7, 2012
From: SYMYX THERAPEUTICS, INC.
To: ILYPSA, INC.
Reel/Frame 027830/0559 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 7, 2012
From: ALPERN, ROBERT; BUYSSE, JERRY; CHANG, HAN TING; CHARMOT, DOMINIQUE; COPE, MICHAEL JAMES; FORDTRAN, JOHN; KLAERNER, GERRIT
To: SYMYX THERAPEUTICS, INC.
Reel/Frame 027820/0053 →