Antimicrobials having polyquaternary ammoniums and alcohol-bearing amidoamines and methods for their use
View Patent ↗Antimicrobial or preservative compositions with high user comfort and/or low ocular irritation. The compositions comprise a polyquaternary ammonium compound and an amidoamine having an alcohol group and exhibit synergistic antimicrobial activity. The compositions may be used as stand-alone antimicrobials/preservatives or may be incorporated into other ocular compositions such as those for ocular lens care or the treatment of ocular conditions.
1. An ophthalmic composition consisting of:
water, a surfactant, a buffer, a tonicity component, a chelating component and an antimicrobial component, wherein said antimicrobial component is a synergistically-antimicrobial amount of poly[(dimethyliminio)-2-butene-1,4-diylchloride (1:1)], a-[4-[tris(2-hydroxyethyl)ammonio]-2-buten-1-yl]-w-[tris(2-hydroxyethyl)ammonio]-chloride and an amidoamine having an alcohol group, the amidoamine having the formula R—CONCH 2 CH 2 CH 2 N(CH 3 ) 2 where R is said alcohol.
2. An ophthalmic composition according to claim 1 , wherein said poly[(dimethyliminio)-2-butene-1,4-diylchloride (1:1)], a-[4-[tris(2-hydroxyethyl)ammonio]-2-buten-1-yl]-w-[tris(2-hydroxyethyl)ammonio]-chloride is present in an amount from about 0.00001% to about 3% w/w and said amidoamine having an alcohol group is present in an amount from about 0.00001% to about 3% w/w.
3. An ophthalmic composition according to claim 1 , wherein said poly[(dimethyliminio)-2-butene-1,4-diylchloride (1:1)], a-[4-[tris(2-hydroxyethyl)ammonio]-2-buten-1-yl]-w-[tris(2-hydroxyethyl)ammonio]-chloride is present in an amount from about 0.00075 to about 1% w/w and said amidoamine having an alcohol group is present in an amount from about 0.0001% to about 1% w/w.
4. An ophthalmic composition according to claim 1 , wherein R has the formula C n H 2n+1 CH(OH)C m H 2m−2 , wherein m and n independently are integers having values of about 1 to about 18.
5. An ophthalmic composition according to claim 1 , wherein said amidoamine is ricinoleamidopropyl dimethylamine.
6. An ophthalmic composition according to claim 1 , having from about 0.00075 to about 1% w/w of poly[(dimethyliminio)-2-butene-1,4-diylchloride (1:1)], a-[4-[tris(2-hydroxyethyl)ammonio]-2-buten-1-yl]-w-[tris(2-hydroxyethyl)ammonio]-chloride and from about 0.0001% to about 1% w/w of said amidoamine wherein R has the formula C n H 2n+1 CH(OH)C m H 2m−2 , wherein m and n independently are integers having values of about 1 to about 18.