Genetically Engineered and Phenotyped Mice and Stem Cell Clones for Producing the Same
The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
1 - 4 . (canceled)
7 . A transgenic mouse whose genome comprises a disruption of a and wherein said disruption results in a phenotype that differs form the phenotype of a wild-type mouse, said gene selected from the group consisting of a gene comprising SEQ ID NO: 10, wherein the disruption of the gene comprising SEQ ID NO: 10 results in impaired learning/memory in (−/−) mice.