STEREOISOMERS OF FATTY ACID ANALOGS FOR DIAGNOSTIC IMAGING
The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a fatty acid analog. The invention also provides methods for using the novel imaging agents, and kits containing one or more of the novel imaging agents of the invention.
1 . A method of imaging cardiovascular tissue in a mammal comprising:
(a) administering to a mammal an imaging agent comprising a radionuclide in spatial proximity to an isomer of a fatty acid analog that includes an aliphatic ring;
(b) detecting the spatial distribution of the imaging agent in the mammal.
2 . The method of claim 1 in which the isomer is a cis or trans isomer.
3 . The method of claim 2 in which the aliphatic ring is a cyclopropyl ring.
4 . The method of claim 2 in which the aliphatic ring is a cyclobutyl ring.
5 . The method of claim 1 in which the aliphatic ring is integral to the fatty acid chain.
6 . The method of claim 1 in which the aliphatic ring is pendent from the fatty acid chain.
7 . The method of claim 1 in which the radionuclide is 11 C, 18 F, 62 Cu, 68 Ga, 99m Tc, 111 In, 123 I, or 131 I.