Pyrimidine amide compounds as PGDS inhibitors

1. A compound of formula (I):

wherein:

R 1 is aryl, heteroaryl, or (C 5 -C 6 )-cycloalkyl, each of which is optionally substituted by halo, (C 1 -C 6 )-alkyl, hydroxy, (C 1 -C 6 )-alkoxy, (C 1 -C 4 )-haloalkyl or (C 1 -C 4 )-haloalkoxy;

R 2 is hydrogen or (C i -C 4 )-alkyl;

R 3 is —P(═O)-(alkoxy) 2 , Y 1 Y 2 N—S0 2 —, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl, or heterocyclenyl, each of which is optionally substituted by:

acyl, cyano, nitro, halo, hydroxy, carboxy, amidino,

R 5 —O—C(═O)—C(═N—OR 4 )—, Y 1 Y 2 N—, Y 1 Y 2 N—C(═O)—, Y 1 Y 2 N—C(═O)—O—,

Y 1 Y 2 N—SO 2 —,

R 7 —SO 2 —NR 6 —, R 7 —C(═O)—NR 6 —, Y 1 Y 2 N—(C 1 -C 4 )-alkylene-SO 2 —(C 1 -C 4 )-alkylene-,

alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, or alkylsulfonyl, each of which is optionally substituted by:

halo, alkoxy, haloalkoxy, hydroxy, carboxy, alkoxycarbonyl, —P(═O)—(alkoxy) 2 , Y 1 Y 2 N—, Y 1 Y 2 N—SO 2—,R 7 —NR 6 —,

aryl or heteroaryl, each of which is optionally substituted by alkyl, halo, haloalkyl, alkoxy, haloalkoxy, hydroxy, amino, alkylamino, dialkylamino, carboxy, or alkoxycarbonyl, or

heterocyclyl or arylheterocyclyl, each of which is optionally substituted by oxo or alkyl, or

aryl, heteroaryl, aroyl, heteroaroyl, aryloxy, heteroaryloxy, or heterocyclyl, each of which is optionally substituted by alkyl, haloalkyl, halo, alkoxy, haloalkoxy, hydroxy, carboxy, alkoxycarbonyl, —P(═O)-(alkoxy) 2 , Y 1 Y 2 N—, or Y 1 Y 2 N—SO 2 —, and

when R 3 is cycloalkyl, cycloalkenyl, heterocyclyl or heterocyclenyl, it is also optionally substituted by oxo;

L 1 is a bond, or (C 1 -C 6 )-alkylene optionally substituted by hydroxyl, or when R 3 is optionally substituted cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl or heterocyclenyl, then the (C 1 -C 6 )-alkylene is also optionally substituted by —P(═O)—(alkoxy) 2 ;

R 4 , R 5 and R 6 are each independently hydrogen or alkyl;

R 7 is alkyl optionally substituted by hydroxy, halo or alkoxy, or

aryl, heteroaryl, arylalkyl or heteroarylalkyl, wherein the aryl, heteroaryl, or the aryl or heteroaryl moiety of the arylalkyl or heteroarylalkyl is optionally substituted by alkyl, haloalkyl, hydroxy, carboxy, alkoxycarbonyl, amino, alkylamino, dialkylamino, halo, alkoxy or haloalkoxy; and

Y 1 and Y 2 are each independently:

hydrogen,

alkyl optionally substituted by:

hydroxy, carboxy, halo, amino, alkylamino, dialkylamino, cycloalkylamino,

aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl,

cycloalkylaminocarbonyl,

alkoxy optionally substituted with hydroxy,

cycloalkyl, heterocyclyl, aryl or heteroaryl, each of which is optionally substituted by alkyl, halo or haloalkyl, or

cycloalkyl optionally substituted by carboxy, or

Y 1 and Y 2 together with the nitrogen atom to which they are attached form a heterocyclyl optionally containing another heteroatom selected from oxygen, nitrogen or sulfur, wherein the heterocyclyl is optionally substituted by alkyl or oxo;

provided that when L 1 is a bond, then R 3 is not optionally substituted phenyl, optionally substituted naphthyl, optionally substituted benzimidazolyl, optionally substituted benzothiazolyl, optionally substituted tetrazolyl, optionally substituted indazolyl, optionally substituted benzotriazolyl, optionally substituted benzisoxazolyl, or optionally substituted benzoxazolyl,

or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 , wherein R 1 is phenyl, five or six-membered heteroaryl, or (C 5 -C 6 )-cycloalkyl, each of which is optionally substituted by halo, (C 1 -C 6 )-alkyl, hydroxy, (C 1 -C 6 )-alkoxy, (C 1 -C 4 )-haloalkyl or (C 1 -C 4 )-haloalkoxy, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

3. The compound according to claim 1 , wherein R 1 is phenyl or five or six membered heteroaryl, each of which is optionally substituted by halo, (C 1 -C 6 )-alkyl, hydroxy, (C 1 -C 6 )-alkoxy, (C 1 -C 4 )-haloalkyl or (C 1 -C 4 )-haloalkoxy, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

4. The compound according to claim 1 , wherein R 1 is phenyl or five or six membered heteroaryl, each of which is optionally substituted by halo, (C 1 -C 6 )-alkyl, hydroxy, (C 1 -C 6 )-alkoxy, (C 1 -C 4 )-haloalkyl or (C 1 -C 4 )-haloalkoxy, or N-oxide thereof, or a pharmaceutically acceptable salt thereof, provide that when R 1 is phenyl or six membered heteroaryl, then it is only optionally substituted at the ortho or meta position.

5. The compound according to claim 1 , wherein R 1 is phenyl, pyridyl, thiazolyl, or imidazolyl, oxadiazolyl, each of which is optionally substituted by halo, (C 1 -C 6 )-alkyl, hydroxy, (C 1 -C 6 )-alkoxy, (C 1 -C 4 )-haloalkyl or (C 1 -C 4 )-haloalkoxy, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

6. The compound according to claim 1 , wherein R 1 is phenyl or pyridyl, each of which is optionally substituted at the ortho or meta position by halo, (C 1 -C 6 )-alkyl, hydroxy, (C 1 -C 6 )-alkoxy, (C 1 -C 4 )-haloalkyl or (C 1 -C 4 )-haloalkoxy, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

7. The compound according to claim 1 , wherein R 1 is phenyl optionally substituted by halo, (C 1 -C 6 )-alkyl, hydroxy, (C 1 -C 6 )-alkoxy, (C 1 -C 4 )-haloalkyl or (C 1 -C 4 )-haloalkoxy, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

8. The compound according to claim 1 , wherein R 1 is phenyl optionally substituted at the ortho or meta position by halo, (C 1 -C 6 )-alkyl, hydroxy, (C 1 -C 6 )-alkoxy, (C 1 -C 4 )-haloalkyl or (C 1 -C 4 )-haloalkoxy, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

9. The compound according to claim 1 , wherein R 1 is phenyl optionally substituted by halo, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

10. The compound according to claim 1 , wherein R 1 is phenyl optionally substituted at the ortho or meta position by halo, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

11. The compound according to claim 1 , wherein R 1 is 2-fluorophenyl or 3-fluorophenyl, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

12. The compound according to claim 1 , wherein R 2 is hydrogen, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

13. The compound according to claim 1 , wherein R 2 is methyl, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

14. The compound according to claim 1 , wherein L 1 is a bond, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

15. The compound according to claim 1 , wherein L 1 is (C 1 -C 3 )-alkylene, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

16. The compound according to claim 1 , wherein L 1 is —CH 2 —, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

17. The compound according to claim 1 , wherein

R 3 is cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl, or heterocyclenyl, each of which is optionally substituted by:

acyl, cyano, nitro, halo, hydroxy, carboxy, amidino,

R 5 O—C(═O)—C(═N—OR 4 )—, Y 1 Y 2 N—, Y 1 Y 2 N—C(═O)—, Y 1 Y 2 N—C(═O)—O—,

Y 1 Y 2 N—SO 2 —,

R 7 —SO 2 —NR 6 —, R 7 —C(═O)—NR 6 —, Y 1 Y 2 N—(C 1 -C 4 )-alkylene-SO 2 —(C 1 -C 4 )-alkylene-, or alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, or alkylsulfonyl, each of which is optionally substituted by:

halo, alkoxy, haloalkoxy, hydroxy, carboxy, alkoxycarbonyl,

—P(═O)-(alkoxy) 2 , Y 1 Y 2 N—, Y 1 Y 2 N—SO 2 —, R 7 —SO 2 —NR 6 —,

aryl or heteroaryl, each of which is optionally substituted by alkyl, halo, haloalkyl, alkoxy, haloalkoxy, hydroxy, amino, alkylamino, dialkylamino, carboxy, or alkoxycarbonyl, or

heterocyclyl or arylheterocyclyl, each of which is optionally substituted by oxo or alkyl, or

aryl, heteroaryl, aroyl, heteroaroyl, aryloxy, heteroaryloxy, or heterocyclyl, each of which is optionally substituted by alkyl, haloalkyl, halo, alkoxy, haloalkoxy, hydroxy, carboxy, alkoxycarbonyl, —P(═O)-(alkoxy) 2 , Y 1 Y 2 N—, or Y 1 Y 2 N—SO 2 —, and

when R 3 is cycloalkyl, cycloalkenyl, heterocyclyl, or heterocyclenyl, it is also optionally substituted by oxo, or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

18. The compound according to claim 1 , wherein R 3 is phenyl, pyridyl, thiazolyl, imidazolyl, oxadiazolyl, imidazolyl, pyrimidinyl, thiophenyl, oxazolyl, cycloalkyl, benzoxazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, tetrahydropyranyl, piperidinyl, furanyl, benzothiazolyl, imidazolidinyl, indazolyl, benzimidazolyl, indolyl, or benzofuranyl, each of which is optionally substituted by:

acyl, cyano, nitro, halo, hydroxy, carboxy, amidino,

R 5 O—C(═O)—C(═N—OR 4 )—,Y 1 Y 2 N—, Y 1 Y 2 N—C(═O)—, Y 1 Y 2 N—C(═O)—O—, Y 1 Y 2 N—SO 2 —,

R 7 —SO 2 —NR 6 —, R 7 —C(═O)—NR 6 —, Y 1 Y 2 N—(C 1 -C 4 )-alkylene-SO 2 —(C 1 -C 4 )-alkylene-, or

alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, or alkylsulfonyl,

each of which is optionally substituted by:

halo, alkoxy, haloalkoxy, hydroxy, carboxy, alkoxycarbonyl, —P(═O)-(alkoxy) 2 ,

Y 1 Y 2 N—, Y 1 Y 2 N—SO 2 —, R 7 —SO 2 —NR 6 —,

aryl or heteroaryl, each of which is optionally substituted by alkyl, halo, haloalkyl, alkoxy, haloalkoxy, hydroxy, amino, alkylamino, dialkylamino, carboxy, or alkoxycarbonyl, or

heterocyclyl or arylheterocyclyl, each of which is optionally substituted by oxo or

alkyl, or

aryl, heteroaryl, aroyl, heteroaroyl, aryloxy, heteroaryloxy, or heterocyclyl, each of which is optionally substituted by alkyl, haloalkyl, halo, alkoxy, haloalkoxy, hydroxy, carboxy, alkoxycarbonyl, —P(═O)-(alkoxy) 2 , Y 1 Y 2 N—, or Y 1 Y 2 N—SO 2 —, and

when R 3 is cycloalkyl, tetrahydropyranyl, piperidinyl, imidazolidinyl, or 1,3-dihydro -benzo[c]isothiazolyl, it is also optionally substituted by oxo,

or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

19. The compound according to claim 1 , wherein:

R 3 is phenyl, pyridyl, thiazolyl, imidazolyl, oxadiazolyl, imidazolyl, pyrimidinyl, thiophenyl, oxazolyl, cycloalkyl, benzoxazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, tetrahydropyranyl, piperidinyl, furanyl, benzothiazolyl, imidazolidinyl, indazolyl, benzimidazolyl

Y 1 Y 2 N—SO 2 —, R 7 —SO 2 —NR 6 —, R 7 —C(═O)—NR 6 -, alkoxy, alkoxycarbonyl, alkylthio,

alkylsulfonyl, aryl, heteroaryl, or

alkyl optionally substituted by:

halo, carboxy, alkoxycarbonyl, aryl or heteroaryl, —P(═O)-(alkoxy) 2 , Y 1 Y 2 N—,

Y 1 Y 2 N—SO 2 —, R 7 —SO 2 —NR 6 —, or

heterocyclyl or arylheterocyclyl, each of which is optionally substituted by oxo,

or

heterocyclyl optionally substituted by Y 1 Y 2 N—, and

when R 3 is cycloalkyl, tetrahydropyranyl, piperidinyl, or imidazolidinyl, it is also optionally substituted by oxo; and

Y 1 and Y 2 are each independently hydrogen, cycloalkyl, or alkyl optionally substituted by hydroxy, alkoxy, amino, alkylamino, dialkylamino, heteroaryl, or heterocyclyl optionally substituted by alkyl,

or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

20. The a compound according to claim 1 , wherein R 3 is phenyl optionally substituted by:

acyl, cyano, nitro, halo, hydroxy, carboxy, amidino,

R 5 O—C(═O)—C(═N—OR 4 )—, Y 1 Y 2 N—, Y 1 Y 2 N—C(═O)—, Y 1 Y 2 N—C(═O)—O—, Y 1 Y 2 N—SO 2 —,

R 7 —SO 2 —NR 6 —, R 7 —C(═O)—NR 6 —, Y 1 Y 2 N—(C 1 -C 4 )-alkylene-SO 2 -(C 1 -C 4 )-alkylene-, or

alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, or alkylsulfonyl,

each of which is optionally substituted by:

halo, alkoxy, haloalkoxy, hydroxy, carboxy, alkoxycarbonyl, —P(═O)-(alkoxy) 2 ,

Y 1 Y 2 N—, Y 1 Y 2 N—SO 2 —, R 7 —SO 2 —NR 6 —,

aryl or heteroaryl, each of which is optionally substituted by alkyl, halo, haloalkyl, alkoxy, haloalkoxy, hydroxy, amino, alkylamino, dialkylamino, carboxy, or alkoxycarbonyl, or

heterocyclyl or arylheterocyclyl, each of which is optionally substituted by oxo or

alkyl, or

aryl, heteroaryl, aroyl, heteroaroyl, aryloxy, heteroaryloxy, or heterocyclyl, each of which is optionally substituted by alkyl, haloalkyl, halo, alkoxy, haloalkoxy, hydroxy, carboxy, alkoxycarbonyl, —P(═O)-(alkoxy) 2 , Y 1 Y 2 N—, or

Y 1 Y 2 N—SO 2 —,

or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

21. The compound according to claim 1 , wherein:

R 3 is phenyl optionally substituted by:

nitro, halo, hydroxy, carboxy, amidino, R 5 O—C(═O)—C(═N—OR 4 )—, Y 1 Y 2 N—,

Y 1 Y 2 N—C(═O)—, Y 1 Y 2 N—SO 2 —, R 7 —SO 2 NR 6 —, R 7 —C(═O)—NR 6 —, alkoxy, alkoxycarbonyl,

alkylthio, alkylsulfonyl, aryl, heteroaryl, or

alkyl optionally substituted by:

halo, carboxy, alkoxycarbonyl, aryl or heteroaryl, —P(═O)-(alkoxy) 2 , Y 1 Y 2 N—,

Y 1 Y 2 N—SO 2 —, R 7 —SO 2 —NR 6 —, or

heterocyclyl or arylheterocyclyl, each of which is optionally substituted by oxo,

or

heterocyclyl optionally substituted by Y 1 Y 2 N—, and

Y 1 and Y 2 are each independently hydrogen, cycloalkyl, or alkyl optionally substituted by hydroxy, alkoxy, amino, alkylamino, dialkylamino, heteroaryl, or heterocyclyl optionally substituted by alkyl,

or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

22. The compound according to claim 1 , wherein R 3 is phenyl optionally substituted by:

Y 1 Y 2 N—So 2 —, R 7 —So 2 —NR 6 -, alkylsulfonyl, or

alkyl substituted by Y 1 Y 2 N—SO 2 —, R 7 —SO 2 —NR 6 —,

or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

23. The compound according to claim 1 , wherein:

R 3 is phenyl optionally substituted by:

Y 1 Y 2 N—SO 2 —, R 7 —SO 2 —NR 6 —, alkylsulfonyl, or

alkyl substituted by Y 1 Y 2 N—SO 2 —, R 7 —SO 2 —NR 6 —; and

Y 1 and Y 2 are each independently hydrogen, cycloalkyl, or alkyl optionally substituted by hydroxy, alkoxy, amino, alkylamino, dialkylamino, heteroaryl, or heterocyclyl optionally substituted by alkyl,

or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

24. A compound, which is

2-Phenyl-pyrimidine-5-carboxylic acid benzylamide,

2-Pyridin-4-yl-pyrimidine-5-carboxylic acid phenylamide,

2-Pyridin-3-yl-pyrimidine-5-carboxylic acid phenylamide,

2-Pyridin-2-yl-pyrimidine-5-carboxylic acid phenylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid phenylamide,

2-(4-Fluoro-phenyl)-pyrimidine-5-carboxylic acid phenylamide,

2-(2-Fluoro-phenyl)-pyrimidine-5-carboxylic acid phenylamide,

2-Phenyl-pyrimidine-5-carboxylic acid [1-(1H-imidazol-2-ylmethyl-piperidin-4-yl]-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (6-dimethylamino-pyridin-3-ylmethyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid [2-(2-pyrrolidin-l-yl-ethyl)-benzooxazol-6yl]-amide,

2-Phenyl-pyrimidine-5-carboxylic acid 4-sulfamoyl-benzylamide,

2-Phenyl-pyrimidine-5-carboxylic acid [2-(4-sulfamoyl-phenyl)-ethyl]-amide,

(R)-2-Phenyl-pyrimidine-5-carboxylic acid [4-(2-oxo-oxazolidin-4-ylmethyl)-phenyl]-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (6-acetylamino-pyridin-3-yl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (3-carbamoyl-phenyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (3-methylcarbamoyl-phenyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (4-hydroxy-cyclohexyl)-amide,

4-methyl-2-[(2-phenyl-pyrimidin-5-carbonyl)-amino]-thiazole-5-carboxylic acid ethyl ester,

{2-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-thiazol-4-yl} -acetic acid ethyl ester,

4-methyl-2-[(2-phenyl-pyrimidin-5-carbonyl)-amino]-thiazole-5-carboxylic acid,

{2-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-thiazol-4-yl} -acetic acid,

2-Phenyl-pyrimidine-5-carboxylic acid 4-methylsulfamoyl-benzylamide,

2-Phenyl-pyrimidine-5-carboxylic acid 4-dimethylsulfamoyl-benzylamide,

2-Phenyl-pyrimidine-5-carboxylic acid (3,5-difluoro-phenyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid pyridin-2-ylamide,

2-Phenyl-pyrimidine-5-carboxylic acid thiazol-2-ylamide,

2-Phenyl-pyrimidine-5-carboxylic acid (3-sulfamoyl-phenyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (2-oxo-1,2-dihydro-pyrimidin-4-yl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (4-sulfamoyl-phenyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid pyrimidin-4-ylamide,

2-Phenyl-pyrimidine-5-carboxylic acid (1-pyridin-3-ylmethyl-piperidin-4-yl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid [2-(2-oxo-imidazolidin-l-yl)-ethyl]-amide,

2-Phenyl-pyrimidine-5-carboxylic acid [2-(1H-imidazol-4-yl)-ethyl]-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (tetrahydro-pyran-4-ylmethyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (3-trifluoromethyl-phenyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (2H-pyrazol-3-yl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (1-methyl-piperidin-4-yl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid pyrimidin-2-ylamide,

2-(3,5-difluoro-phenyl)-pyrimidine-5-carboxylic acid 3-methylsulfamoyl-benzylamide,

2-(2,5-difluoro-phenyl)-pyrimidine-5-carboxylic acid 3-methylsulfamoyl-benzylamide,

2-(4-difluorophenyl)-4-methylpyrimidine-5-carboxylic acid-3-methylsulfamoyl-benzylamide,

2-(2-pyridyl)-pyrimidine-5-carboxylic acid-3-methylsulfamoyl-benzylamide, 2-(3-pyridyl)-4-methyl-pyrimidine-5-carboxylic acid-3-methylsulfamoyl-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-ethylsulfamoyl-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(2-ethoxy-ethylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(2-hydroxy-propylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-cyclopropylsulfamoyl-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(3-hydroxy-propylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(2-methoxy-ethylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(3-methoxy-propylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(4-methoxy-butylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-cyclohexylsulfamoyl-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(2-hydroxy-1,1-dimethyl-ethylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-sulfamoyl-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(2-morpholin-4-yl-ethylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(2-piperidin-l-yl-ethylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-[2-(1-methyl-pyrrolidin-2-yl)-ethylsulfamoyl]-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-[(1-ethyl-pyrrolidin-2-ylmethyl)-sulfamoyl]-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-[2-(1H-imidazol-4-yl)-ethylsulfamoyl]-benzylamide,

2-(3 -Fluoro-phenyl)-pyrimidine-5 -carboxylic acid 3 43 -(2-methyl-piperidin- 1-yl)-propylsulfamoyll-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(3-pyrrolidin-l-yl-propylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(2-dimethylamino-ethylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(2-diethylamino-ethylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(3-dimethylamino-2,2-dimethyl-propylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(5-dimethylamino-pentylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(2-diisopropylamino-ethylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid 3-(methanesulfonylamino-methyl)-benzylamide,

2-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid 3-[(propane-2-sulfonylamino)-methyl]-benzylamide,

2-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid 3-methylsulfamoylmethyl-benzylamide,

2-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid 3-(isopropylsulfamoyl-methyl)-benzylamide,

2-(3-Fluoro-phenyl)- pyrimidine-5-carboxylic acid 3-(methanesulfonylamino-methyl)-benzylamide,

2-(3-Fluoro-phenyl)- pyrimidine-5-carboxylic acid 3-[(propane-2-sulfonylamino)-methyl]-benzylamide,

2-(3-Fluoro-phenyl)- pyrimidine-5-carboxylic acid 3-methylsulfamoylmethyl-benzylamide,

2-(3-Fluoro-phenyl)- pyrimidine-5-carboxylic acid 3-(isopropylsulfamoyl-methyl)-benzylamide

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (2-methanesulfonylamino-pyridin-4-ylmethyl)-amide,

2-(5-Methyl-[1,2,4]oxadiazole-3-yl)-pyrimidine-5-carboxylic acid (tetrahydro-pyran-4-yl)-amide,

2-(5-Methyl-[1,2,4]oxadiazole-3-yl)-pyrimidine-5-carboxylic acid 4 sulfamoyl-benzeneamide,

2-(5-Methyl-[1,2,4]oxadiazol-3-yl)-pyrimidine-5-carboxylic acid (3-phenyl-[1,2,4]thiadiazol-5-y1)-amide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(morpholine-4-sulfonyl)-benzylamide,

2-Pheny-pyrimidine-5-carboxylic acid 3,4-dimethoxyl-benzylamide,

2-Pheny-pyrimidine-5-carboxylic acid (1H-indazol-5-yl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid 4-[1,2,3]thiadiazol-5-yl)-benzylamide,

2-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid 3-methylsulfamoyl-benzylamide,

4-Methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid 3-methylsulfamoyl-benzylamide,

2-Pheny-pyrimidine-5-carboxylic acid 4-morpholin-4-ylbenzylamide,

6-[(2-Phenyl-pyrimidin-5-carbonyl)-amino]-1H-benzoimidazole-2-carboxylic acid methyl ester,

6-[(2-Phenyl-pyrimidin-5-carbonyl)-amino]-1H-benzoimidazole-2-carboxylic acid,

2-Pheny-pyrimidine-5-carboxylic acid (benzofuran-5-ylmethyl)-amide,

2-Pheny-pyrimidine-5-carboxylic acid 4-methanesulfonylamino-benzylamide,

2-Pheny-pyrimidine-5-carboxylic acid 4-carbamoyl-benzylamide,

2-Pheny-pyrimidine-5-carboxylic acid 3-(2-hydroxy-ethylsulfamoyl)-benzylamide,

2-Pheny-pyrimidine-5-carboxylic acid 4-(morpholin-4-sulfonyl)-benzylamide,

2-Pheny-pyrimidine-5-carboxylic acid 3-methylsulfamoyl-benzylamide,

2-Pheny-pyrimidine-5-carboxylic acid [2-(2-amino-4-methyl-thiazol-5-yl)-ethyl]-amide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-methylsulfamoyl-benzylamide,

{4- {[(2-Phenyl-pyrimidine-5-carbonyl)-amino]-benzyl}-phosphonic acid diethyl ester,

{4-[(2-Phenyl-pyrimidine-5-carbonyl)-amino]-butyl)-phosphonic acid diethyl ester,

{4-[(2-Phenyl-pyrimidine-5-carbonyl)-amino]-ethyl)-phosphonic acid diethyl ester,

{Phenyl-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-methyl)-phosphonic acid diethyl ester,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-methanesulfonyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (1-methanesulfonyl-piperidin-3-ylmethyl)-amide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (1-dimethanesulfamoyl-piperidin-3-ylmethyl)-amide,

2-(Phenyl)-pyrimidine-5-carboxylic acid 3-methanesulfonylamino-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-acetylsulfamoyl-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(3-oxo-piperiazine-l-sulfonyl)-benzylamide,

2-Pheny-pyrimidine-5-carboxylic acid (2-sulfamoyl-ethyl)-amide,

2-Pheny-pyrimidine-5-carboxylic acid (2-dimethylsulfamoyl-ethyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (3-phenyl-[1,2,4]thiadiazol-5-yl)-amide,

4-Methyl-2-phenyl-pyrimidine-5-carboxylic acid (3-phenyl-[1,2,4]thiadiazol-5-yl)-amide

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (3-phenyl-[1,2,4]thiadiazol-5-yl)amide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (tetrahydro-pyran-4-yl)-amide,

2-Cyclohexyl-pyrimidine-5-carboxylic acid phenylamide,

2-Phenyl-pyrimidine-5-carboxylic acid 3-amino-benzylamide,

2-(3-Pyridyl)-pyrimidine-5-carboxylic acid-3-methylsulfamoyl-benzylamide,

2-Pyrazol-1-yl-pyrimidine-5-carboxylic acid 4-sulfamoyl-benzylamide,

2-(2-Methyl-thiazol-4-yl)-pyrimidine-5-carboxylic acid (tetrahydro-pyran-4-yl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (thiophen-2-ylmethyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (4-methyl-oxazol-2-yl)-amide,

Methoxyimino-{2-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-thiazol-4-yl}-acetic acid ethyl ester,

2-Phenyl-pyrimidine-5-carboxylic acid (5-methylsulfanyl-[1,3,4]thiadiazol-2-yl)-amide,

2-[(2-Phenyl-pyrimidine-5-carbonyl)-amino]-benzothiazole-5-carboxylic acid ethyl ester,

(R)-2-Phenyl-pyrimidine-5-carboxylic acid (1-phenyl-ethyl)-amide,

2-Phenyl-pyrimidine-5-carboxylic acid [3-(1H-tetrazol-5-yl)-phenyl]-amide,

2-Phenyl-pyrimidine-5-carboxylic acid (1-carbamimidoyl-piperidin-4-ylmethyl)-amide,

5-[(2-Phenyl-pyrimidine-5-carbonyl)-amino]-1H-indole-3-carboxylic acid amide,

2-Phenyl-pyrimidine-5-carboxylic acid [3-(2-amino-thiazol-4-yl)-phenyl]-amide,

2-Phenyl-pyrimidine-5-carboxylic acid {4-[2-(1,3-dioxo-1,3-dihydro-isoindo1-2-yl)-ethyl]-thiazol-2-yl} -amide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid [2-(pyrrolidine-l-sulfonyl)-ethyl]-amide,

[3 -({ [2-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-methyl)-benzyl]-carbamic acid tert-butyl ester,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-[(pyridin-2-ylmethyl)-sulfamoyl]-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(3-hydroxy-2,2-dimethyl-propylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(2-hydroxy-2-methyl-propylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-[(tetrahydro-pyran-4-ylmethyl)-sulfamoyl]-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-(4-hydroxy-butylsulfamoyl)-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 342-(2-hydroxy-ethoxy)-ethylsulfamoyll-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-[(tetrahydro-furan-2-ylmethyl)-sulfamoyl]-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid 3-isobutylsulfamoyl-benzylamide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (5-isopropylsulfamoyl-pyridin-3-ylmethyl)-amide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (5-methylsulfamoyl-pyridin-3-ylmethyl)-amide,

2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (2-methylsulfamoyl-pyridin-4-ylmethyl)-amide,

2-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid (2-methylsulfamoyl-pyridin-4-ylmethyl)-amide, or

2-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid (5-isopropylsulfamoyl-pyridin-3-ylmethyl)-amide,

or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

25. A pharmaceutical composition comprising the compound according to claim 1 , or N-oxide thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

26. A pharmaceutical composition comprising the compound according to claim 24 , or N-oxide thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

27. A method for treating allergic rhinitis, asthma or chronic obstructive pulmonary disease, in a patient in need thereof, comprising administering to the patient a pharmaceutically effective amount of the compound according to claim 1 , or N-oxide thereof, or a pharmaceutically acceptable salt thereof.

28. A method for treating allergic rhinitis, asthma or chronic obstructive pulmonary disease, in a patient in need thereof, comprising administering to the patient a pharmaceutically effective amount of the compound according to claim 24 , or N-oxide thereof, or a pharmaceutically acceptable salt thereof.