IP Library Granted Patent US 8,158,728
Granted Patent B2
US 8,158,728 · App. 12/063,284 · Granted Apr 17, 2012

Methods and materials for fabricating microfluidic devices

Assignee: The University of North Carolina at Chapel Hill
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Quick Facts
Patent No.
US 8,158,728
App. No.
12/063,284
Granted
Apr 17, 2012
Kind
B2
Abstract

Materials and Methods are provided for fabricating microfluidic devices. The materials include low surface energy fluoropolymer compositions having multiple cure functional groups. The materials can include multiple photocurable and/or thermal-curable functional groups such that laminate devices can be fabricated. The materials also substantially do not swell in the presence of hydrocarbon solvents.

Claims (31)

1. A polymer composition, comprising:

a first component including a fluoropolymer having a first curable functional group, wherein the fluoropolymer having a first curable functional group comprises a diurethane methacrylate functionalized perfluoropolyether having one of the following structures:

wherein n′ is an integer from 1 to 100, and n is one; and a second component including a polymer having a second curable functional group, wherein the polymer having said second curable functional group is a fluoropolymer, wherein said fluoropolymer comprises:

(a) a diisocyanate functionalized perfluoropolyether having a structure of:

wherein n′ is an integer from 1 to 100;

(b) a diisocyanate functionalized perfluoropolyether having a structure of:

wherein n′ is an integer from 1 to 100;

(c) a diepoxy functionalized perfluoropolyether having a structure of:

wherein n′ is an integer from 1 to 100; or

(d) a diamine functionalized perfluoropolyether having a structure of:

wherein n′ is an integer from 1 to 100.

2. The polymer composition of claim 1 , further comprising a third component including a fluoropolymer having a third curable functional group, wherein said third curable functional group comprises a tetrol functionalized perfluoropolyether having a structure of:

wherein n′ is an integer from 1 to 100;

or a triol functionalized perfluoropolyether having a structure of:

wherein n′ is an integer from 1 to 100.

3. The composition of claim 2 , wherein the first curable functional group reacts at a first wavelength and the second curable functional group reacts at a second time period, wherein following activation of the second curable functional group the composition can be bound to a substrate through activation of the third curable functional group.

4. The composition of claim 2 , wherein the second curable functional group reacts at a first time period and the third curable functional group reacts at a second time period, wherein following activation of the second curable functional group the composition can be bound to a substrate through activation of the third curable functional group.

5. The composition of claim 2 , wherein the second curable functional group reacts at a first temperature and the third curable functional group reacts at a second temperature, wherein following activation of the second curable functional group the composition can be bound to a substrate through activation of the third curable functional group.

6. The polymer composition of claim 1 , wherein the polymeric material has a surface energy of less than about 20 dynes/cm.

7. The polymer composition of claim 1 , wherein the polymeric material has a surface energy of less than about 18 dynes/cm.

8. The polymer composition of claim 1 , wherein the polymeric material has a surface energy of less than about 15 dynes/cm.

9. The composition of claim 1 , wherein the second curable functional group remains viable after the first curable functional group is activated such that the second curable functional group can bind with a group consisting of another polymer, a hydroxyl group, another functional group, and combinations thereof.

10. The composition of claim 1 , wherein the perfluoropolyether has a molecular weight of about 16000 and a modulus of about 800 kPa.

11. The composition of claim 1 , wherein the perfluoropolyether has a molecular weight of less than about 16000.

12. The composition of claim 1 , wherein the perfluoropolyether has a modulus of greater than about 500 kPa.

13. The composition of claim 1 , wherein the perfluoropolyether has a molecular weight of about 16000 and a percent elongation at break of about 200 percent.

14. The composition of claim 1 , wherein the perfluoropolyether has a percent elongation at break of less than about 200 percent.

15. The composition of claim 1 , wherein one of the first component or the second component includes a fluoropolymer having an elongation at break of about 300 percent.

16. The composition of claim 1 , wherein one of the first component or the second component includes a fluoropolymer having an elongation at break of about 200 percent.

17. The composition of claim 1 , wherein one of the first component or the second component includes a fluoropolymer having an elongation at break of between about 100 percent and about 300 percent.

18. The composition of claim 1 , wherein one of the first component or the second component includes a perfluoropolyether having an elongation at break of between about 200 percent and about 300 percent.

Assignments (5)
ASSIGNMENT OF IP SECURITY AGREEMENT RECORDED AT REEL/FRAME 062643/0791 Recorded May 11, 2023
From: HCR COLLATERAL MANAGEMENT, LLC, AS RETIRING SUBORDINATED LENDER
To: HEALTHCARE ROYALTY PARTNERS IV, L.P., AS SUCCESSOR SUBORDINATED LENDER
Reel/Frame 063627/0307 →
SECURITY INTEREST Recorded Feb 9, 2023
From: LIQUIDIA TECHNOLOGIES, INC.
To: HCR COLLATERAL MANAGEMENT, LLC
Reel/Frame 062643/0791 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2013
From: ROTHROCK, GINGER
To: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Reel/Frame 030911/0090 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2013
From: RESNICK, PAUL
To: LIQUIDIA TECHNOLOGIES, INC.
Reel/Frame 030921/0435 →
CONFIRMATORY LICENSE Recorded Mar 19, 2009
From: NORTH CAROINA, UNIVERSITY OF
To: NAVY, SECRETARY OF THE, UNITED STATES OF AMERICA OFFICE OF NAVAL RESEARCH
Reel/Frame 022431/0871 →
Continuity (6)
Continuation In Part PCTUS2005004421 · Feb 14, 2005
Provisional Application 60706786 · Aug 9, 2005
Provisional Application 60732727 · Nov 2, 2005
Provisional Application 60799317 · May 10, 2006
Provisional Application 60544905 · Feb 13, 2004
Related Publication 20090281250A1 · Nov 12, 2009