Formulation having accurate dose-dividing function
View Patent ↗The present invention provides a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, and having a scored line capable of dividing the whole tablet on the connecting part; particularly, a coated tablet in which a connecting part and a coating layer have the same or different drug release controlling functions; a tablet having an insoluble coating on a drug-containing part having a scored line, wherein the drug-containing part has a structure or composition such that the drug is substantially released after the tablet is divided along the scored line and then ingested; and a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, wherein at least two drug-containing parts have different compositions. In addition, the present invention provides a method of manufacturing a tablet, wherein a column comprising a plurality of columnar pharmaceutical composition layers having the same cross-section and laminated in the axial direction of the column is compression molded and then compression molded in a direction different from the axial direction of the column.
1. A method of manufacturing a tablet, comprising:
(a) compression molding a column having a plurality of columnar pharmaceutical composition layers having the same cross-section and laminated in the axial direction of the column; and
(b) compression molding the column in a direction different from the axial direction thereof,
wherein the entire column is compressed into different shape in the compression molding in (b).
2. The manufacturing method according to claim 1 , wherein both ends of the column are a pharmaceutical composition layer containing no drug.
3. A manufacturing method of a tablet, comprising compression molding an entire multilayer column having columnar drug-containing parts and a columnar connecting part(s) laminated alternatively in the axial direction of the column with the drug-containing parts disposed at both ends, in a direction different from the axial direction of the column, wherein the column is compressed into a different shape.
4. The manufacturing method according to claim 3 , wherein a scored line is prepared during the compression molding or thereafter, as required.
5. The manufacturing method according to any of claims 1 to 4 , wherein the direction different from the axial direction of the column is a direction perpendicular to the axial direction of the column.
6. The manufacturing method according to any of claims 1 to 4 , wherein the column to be compression molded is a 3-layer column.
7. A tablet manufactured by the method, according to claim 1 .