Pyrazine compounds and uses as PI3K inhibitors

1. A compound according to Formula (I),

wherein:

A, B, D and E, each of which may be optionally substituted, are C, such that the ring R is an aromatic ring;

R 1 is selected from H, halogen, nitro, optionally substituted C 1 -C 6 -alkyl, optionally substituted C 2 -C 6 -alkenyl or optionally substituted C 2 -C 6 -alkynyl;

R 2 is selected from H, optionally substituted C 1 -C 6 -alkyl, optionally substituted C 2 -C 6 -alkenyl or optionally substituted C 2 -C 6 -alkynyl;

R 3 is selected from H, halo, optionally substituted C 1 -C 6 -alkyl, optionally substituted C 2 -C 6 -alkenyl, optionally substituted C 2 -C 6 -alkynyl, optionally substituted alkoxy, optionally substituted aryl or optionally substituted heteroaryl;

R 4 is selected from optionally substituted C 1 -C 6 -alkyl, optionally substituted C 2 -C 6 -alkenyl, optionally substituted C 2 -C 6 -alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl C 1 -C 6 -alkyl, optionally substituted heteroaryl C 1 -C 6 -alkyl, optionally substituted C 3 -C 8 cycloalkyl optionally substituted C 1 -C 6 -alkyl, optionally substituted heterocycloalkyl C 1 -C 6 -alkyl, optionally substituted aryl C 2 -C 6 -alkenyl or optionally substituted heteroaryl C 2 -C 6 -alkenyl;

n is an integer selected from 0, 1, 2, 3 and 4;

an optionally substituted group may be substituted with from 1 to 5 substituents selected from the group consisting of C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, cycloalkyl, heterocycloalkyl, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl, C 1 -C 6 -alkyl cycloalkyl, C 1 -C 6 -alkyl heterocycloalkyl, amino, ammonium, acyl, acyloxy, acylamino, aminocarbonyl, alkoxycarbonyl, ureido, aryl, carbamate, heteroaryl, sulfinyl, sulfonyl, alkoxy, sulfanyl, halogen, carboxy, trihalomethyl, cyano, hydroxy, mercapto and nitro;

with the first proviso that when R 4 is thiophenyl, it is not selected from group consisting of: unsubstituted thiophenyl, unsubstituted chloro-5-thiophenyl and unsubstituted bromo-5-thiophenyl;

with the second proviso that when R 4 is a phenyl, it is a mono-substituted phenyl that is not selected from the group consisting of: p-bromo phenyl; p-methoxy phenyl; p-ethoxy phenyl; o-, m- or p-chloro phenyl; m- or p-methyl phenyl; o- or p-fluoro phenyl; o-CF3-phenyl; p- or m-nitro phenyl; p-NHAc-phenyl and p-amino phenyl; or it is a multi-substituted phenyl, that is not an unsubstituted bi-substituted phenyl selected from the group consisting of: m-, p-dimethyl phenyl; m-, m-dimethyl phenyl; o-, p-dimethyl phenyl; o-, m-dimethyl phenyl; o-methyl p-fluoro phenyl; m-, m-dichloro phenyl; o-, m-dichloro phenyl; p-chloro m-nitro phenyl and o-ethoxy m-bromo phenyl;

with the final proviso that wherein R 4 is a 1,4 benzodioxin it is a substituted benzodioxin;

or an optically active form or a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 , wherein R 1 is selected from H or halogen.

3. The compound according to claim 1 , wherein R 2 is methyl, which may be optionally substituted.

4. The compound according to claim 1 , wherein R 3 is selected from H or alkoxy, which may be optionally substituted.

5. The compound according to claim 1 , wherein R 3 is selected from halo, optionally substituted aryl or optionally substituted heteroaryl.

6. The compound according to claim 1 , wherein R 4 is selected from optionally substituted C 1 -C 6 -alkyl, optionally substituted C 2 -C 6 -alkenyl, optionally substituted C 2 -C 6 -alkynyl, optionally substituted aryl C 1 -C 6 -alkyl or optionally substituted heteroaryl C 1 -C 6 -alkyl.

7. The compound according to claim 1 , wherein R 1 is selected from optionally substituted aryl or optionally substituted heteroaryl.

8. The compound according to claim 1 , wherein R 1 is selected from H and halogen; R 2 is substituted methyl; and R 3 is selected from H or substituted alkoxy.

9. The compound according to claim 1 , wherein R 1 is selected from H and halogen; R 2 is methyl; R 3 is selected from H or alkoxy.

10. The compound according to claim 1 , wherein said compound is selected from:

4-cyano-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide;

3-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]benzoic acid;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-1-methyl-1H-imidazole-4-sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-methylbenzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-methylbenzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-methylbenzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-methylbenzene sulfonamide;

5-bromo-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}thiophene-2-sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-1-pyridin-3-ylmethane sulfonamide;

Methyl 3-{4-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]phenyl}propanoate;

Methyl 4-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]benzoate;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-fluorobenzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-(methylsulfonyl)benzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-2,3-dihydro-1,4-benzodioxine-6-sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-(pyrrolidin-1-yl sulfonyl)benzenesulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-(methylsulfonyl)benzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-(methylsulfonyl)benzene sulfonamide;

2-cyano-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

2-cyano-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

2-chloro-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}pyridine-3-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-1-methyl-1H-imidazole-4-sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-fluorobenzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-fluorobenzene sulfonamide;

4-cyano-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}methanesulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}thiophene-3-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}methanesulfonamide;

3-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]benzoic acid;

Methyl 4-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]benzoate;

Methyl 3-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]thiophene-2-carboxylate;

5-chloro-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-1,3-dimethyl-1H-pyrazole-4-sulfonamide;

4-chloro-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

3-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]thiophene-2-carboxylic acid;

3-{4-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]phenyl}propanoic acid;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-methyl-2-oxo-2,3-dihydro-1,3-benzothiazole-6-sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-2,1,3-benzothiadiazole-4-sulfonamide;

4-chloro-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-methyl-2-oxo-2,3-dihydro-1,3-benzothiazole-6-sulfonamide;

4-bromo-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

4-bromo-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

4-acetyl-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-benzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}propane-1-sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}thiophene-3-sulfonamide;

4-acetyl-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-1,2-dimethyl-1H-imidazole-5-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-2,1,3-benzoxadiazole-4-sulfonamide;

3-chloro-N-{3-[(3-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

3-cyano-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]phenyl}acetamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}propane-1-sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-(trifluoromethyl)benzene sulfonamide;

4-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]butanoic acid;

3-chloro-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{6-chloro-3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-1-pyridin-2-ylmethane sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-methoxybenzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]pyrido[2,3-b]pyrazin-2-yl}ethane sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-methoxybenzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-1-pyridin-2-ylmethane sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-1-pyridin-3-ylmethane sulfonamide;

Methyl 3-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]thiophene-2-carboxylate;

N-{3-[(3-methoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide;

N-{3-[(3-methoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide;

4-chloro-N-{3-[(3-methoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-methoxybenzene sulfonamide;

4-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]butanoic acid;

N-{3-[(3-methoxyphenyl)amino]quinoxalin-2-yl}methanesulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-iodobenzene sulfonamide;

4-bromo-N-{3-[(3-methoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

4-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]benzoic acid;

Methyl 4-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]butanoate;

4-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]benzoic acid;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-2-fluorobenzene sulfonamide;

N-(3-{[5-methoxy-2-(1H-pyrrol-1-yl)phenyl]amino}quinoxalin-2-yl)benzene sulfonamide;

Methyl 3-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]benzoate;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-6-morpholin-4-yl pyridine-3-sulfonamide;

4-methoxy-N-{3-[(3-methoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

Methyl 3-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]benzoate;

3-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]thiophene-2-carboxylic acid;

N-{3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-2-(methylsulfonyl)benzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-2-fluorobenzene sulfonamide;

4,5-dichloro-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}thiophene-2-sulfonamide;

N-{3-[(5-methoxy-2-methylphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-fluorobenzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-2-(methylsulfonyl)benzenesulfonamide;

N-{3-[(2,3-dihydro-1,4-benzodioxin-5-ylmethyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]-6-nitroquinoxalin-2-yl}benzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-(pyrrolidin-1-ylsulfonyl)benzene sulfonamide;

methyl 4-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino) sulfonyl]butanoate;

methyl 5-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-4-methylthiophene-2-carboxylate;

methyl 5-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-1-methyl-1H-pyrrole-2-carboxylate;

methyl5-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-1-methyl-1H-pyrrole-2-carboxylate;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}thiophene-2-sulfonamide;

2-chloro-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-fluorobenzene sulfonamide;

2-chloro-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-fluorobenzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}pyridine-3-sulfonamide;

3-cyano-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-fluorobenzene sulfonamide;

3-cyano-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-fluorobenzene sulfonamide;

6-chloro-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}pyridine-3-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-6-(dimethylamino)pyridine-3-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-6-[(3-methoxypropyl)amino]pyridine-3-sulfonamide;

N-{3-[(5-methoxy-2-methylphenyl)amino]quinoxalin-2-yl}pyridine-3-sulfonamide;

N-{3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl}-4-cyano benzene sulfonamide;

N-{3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl}pyridine-3-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-6-methoxypyridine-3-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-6-oxo-1,6-dihydropyridine-3-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-6-methylpyridine-3-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-fluoro-2-methylbenzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-6-methylpyridine-3-sulfonamide;

4-cyano-N-{3-[(5-methoxy-2-methylphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[(5-methoxy-2-methylphenyl)amino]quinoxalin-2-yl}-6-methylpyridine-3-sulfonamide;

N-{3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl}-6-methylpyridine-3-sulfonamide;

methyl 5-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]pyridine-2-carboxylate;

N-[3-[(2-bromo-5-methoxyphenyl)amino]quinoxalin-2-yl]-1-methyl-1H-imidazole-4-sulfonamide;

N-3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl]-3-(morpholin-4-ylcarbonyl)benzenesulfonamide;

5-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-4-methyl thiophene-2-carboxylic acid;

5-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-4-methyl thiophene-2-carboxylic acid;

5-[({3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid;

5-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid;

5-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]pyridine-2-carboxylic acid;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-(morpholin-4-ylmethyl)benzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-[(4-methylpiperazin-1-yl)methyl]benzenesulfonamide;

4-(aminomethyl)-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-(hydroxymethyl)benzenesulfonamide;

3-(aminomethyl)-N-[3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl]benzenesulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-(hydroxymethyl)benzenesulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-6-(hydroxymethyl)pyridine-3-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-(morpholin-4-ylmethyl)benzene sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-[(4-methylpiperazin-1-yl)methyl]benzenesulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-[(dimethylamino)methyl]benzenesulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-[(dimethylamino)methyl]benzenesulfonamide;

4-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]benzamide;

4-[({3-[(5-methoxy-2-methylphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]benzamide;

4-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-N-(3-methoxypropyl)benzamide;

4-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-N-[3-(dimethylamino)propyl]benzamide;

3-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-N-[3-(dimethylamino)propyl]benzamide;

5-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]-N,N-dimethylpyridine-2-carboxamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-3-[(4-methylpiperazin-1-yl)carbonyl]benzenesulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-6-(morpholin-4-ylcarbonyl)pyridine-3-sulfonamide;

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-6-[(4-methylpiperazin-1-yl)methyl]pyridine-3-sulfonamide; or

5-(aminomethyl)-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}thiophene-2-sulfonamide.

11. The compound according to claim 1 , wherein said compound is selected from:

4-cyano-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide;

2-chloro-N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

5-chloro-N-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl]-1,3-dimethyl-1H-pyrazole-4-sulfonamide;

N-{3-[({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}amino)sulfonyl]phenyl}acetamide;

3-cyano-N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}benzene sulfonamide;

N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-(trifluoromethyl)benzene sulfonamide; or

4-fluoro-N-{[(3-methoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide; and

N-{3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-4-iodobenzene sulfonamide.

12. A pharmaceutical composition containing at least one pyrazine compound according to claim 1 and a pharmaceutically acceptable carrier, diluent or excipient thereof.

13. A process for the preparation of pyrazine compound according to claim 1 , comprising reacting a compound of Formula (II) with an aniline of Formula (III) in absence of a base:

wherein n, A, B, D, E, R, R 1 , R 2 , R 3 , R 4 are as defined in claim 1 .

14. A process for the preparation of pyrazine compound according to claim 1 , comprising reacting an amino compound of Formula (XI) and a sulfonylchloride of Formula (IX) in the presence of a base:

wherein n, A, B, D, E, R, R 1 , R 2 , R 3 , R 4 are as defined in claim 1 .

15. The process according to claim 14 wherein the base is pyridine.

16. The compound according to claim 1 , wherein R 1 is H, R 2 is an optionally substituted C 1 -C 6 alkyl, R 3 is a C 1 -C 6 alkyl optionally substituted with hydroxyl and R 4 is an optionally substituted heteroaryl.