Capsule formulation of pirfenidone and pharmaceutically acceptable excipients
View Patent ↗A capsule formulation of pirfenidone is provided that includes pharmaceutically acceptable excipients. In one embodiment, this capsule formulation is capable of sustaining desirable pharmacokinetic responses in a patient. Further provided are methods of treating fibrotic conditions and other cytokine-mediated disorders by administering pirfenidone capsules of such formulation to a patient in need.
1. A capsule comprising a pharmaceutical formulation of 5-methyl-1-phenyl-2-(1H)-pyridone, wherein said pharmaceutical formulation comprises 5-methyl-1-phenyl-2-(1H)-pyridone and pharmaceutically acceptable excipients, said excipients comprising an effective amount of binder to increase the AUC of pirfenidone upon oral administration, as compared to a capsule comprising no excipients.
2. The capsule of claim 1 , wherein said excipients further comprise one or more selected from the group consisting of disintegrators, fillers, and lubricants.
3. The capsule of claim 2 , wherein said disintegrators comprise one or more selected from the group consisting of agar-agar, algins, calcium carbonate, carboxmethylcellulose, cellulose, clays, colloid silicon dioxide, croscarmellose sodium, crospovidone, gums, magnesium aluminium silicate, methylcellulose, polacrilin potassium, sodium alginate, low substituted hydroxypropylcellulose, and cross-linked polyvinylpyrrolidone hydroxypropylcellulose, sodium starch glycolate, and starch.
4. The capsule of claim 1 , wherein said binder comprises one or more selected from the group consisting of microcrystalline cellulose, hydroxymethyl cellulose, hydroxypropylcellulose, and polyvinylpyrrolidone.
5. The capsule of claim 2 , wherein said fillers comprise one or more selected from the group consisting of calcium carbonate, calcium phosphate, dibasic calcium phosphate, tribasic calcium sulfate, calcium carboxymethylcellulose, cellulose, dextrates, dextrin, dextrose, fructose, lactitol, lactose, magnesium carbonate, magnesium oxide, maltitol, maltodextrins, maltose, sorbitol, starch, sucrose, sugar, and xylitol.
6. The capsule of claim 2 , wherein said lubricants comprise one or more selected from the group consisting of agar, calcium stearate, ethyl oleate, ethyl laureate, glycerin, glyceryl palmitostearate, hydrogenated vegetable oil, magnesium oxide, magnesium stearate, mannitol, poloxamer, glycols, sodium benzoate, sodium lauryl sulfate, sodium stearyl, sorbitol, stearic acid, talc, and zinc stearate.
7. The capsule of claim 2 , wherein by weight said disintegrator is 2-10%, said binder is 2-30%, said filler is 2-30%, and said lubricant is 0.3-0.8%.
8. The capsule of claim 1 , wherein said binder comprises povidone.
9. The capsule of claim 8 , wherein said povidone is 1-4% by weight of the formulation.
10. The capsule of claim 9 , comprising 100-400 mg 5-methyl-1-phenyl-2-(1H)-pyridone.
11. A method for treating a fibrotic condition or inhibiting actions of cytokines, comprising administering the capsule of claim 1 to a patient suffering from said fibrotic condition or suffering from a disorder mediated by said cytokines.
12. The method of claim 11 , wherein said fibrotic condition is one selected from the group consisting of pulmonary fibrosis, hepatic fibrosis, cardiac fibrosis, keloid, dermal fibrosis, coronary restenosis, and post-surgical adhesions.
13. The method of claim 12 , wherein said pulmonary fibrosis is one selected from the group consisting of idiopathic pulmonary fibrosis and Hermansky-Pudlak Syndrome.
14. The method of claim 11 , wherein said cytokines comprise one or more selected from the group consisting of TNF-α, TGF-β1, bFGF, PDGF, and EGF.
15. The method of claim 14 , wherein said disorder is one selected from the group consisting of multiple sclerosis, arthritis, asthma, chronic rhinitis, and edema.
16. The method of claim 11 comprising administering one or more said capsules to said patient one or more times a day, wherein the total intake of 5-methyl-1-phenyl-2-(1H)-pyridone is at least 1200 mg a day.
17. The method of claim 16 , wherein said one or more capsules are administered to the patient twice a day or three times a day.
18. The method of claim 11 , wherein said fibrotic condition is a pulmonary fibrotic condition.
19. The capsule of claim 1 , wherein the formulation comprises a wet-granulated mixture comprising 5-methyl-1-phenyl-2-(1H)-pyridone, binder, filler, and disintegrator.
20. The capsule of claim 8 , wherein said povidone comprises at least about 1% by weight of the formulation.
21. The capsule of claim 8 , wherein said povidone comprises at least about 1.85% by weight of the formulation.
22. The capsule of claim 9 , wherein the binder further comprises microcrystalline cellulose.
23. The capsule of claim 1 , wherein the total amount of binder is 2-30% by weight of the formulation.
24. The capsule of claim 1 , wherein the binder comprises microcrystalline cellulose.
25. The capsule of claim 1 , wherein:
the pharmaceutically acceptable excipients comprise a lubricant, a filler, and a disintegrator;
the binder comprises microcrystalline cellulose and povidone;
the povidone is included in an amount of 1-4% by weight of the formulation;
the total amount of binder is 2-30% by weight of the formulation; and
the formulation comprises a wet-granulated mixture comprising the 5-methyl-1-phenyl-2-(1H)-pyridone , the binder, the filler, and the disintegrator.
26. The capsule of claim 1 , wherein said effective amount of binder increases the AUC of pirfenidone upon oral administration at least 30%, as compared to a capsule comprising no excipients.
27. The capsule of claim 26 , wherein said effective amount of binder increases the AUC of pirfenidone upon oral administration at least 40%, as compared to a capsule comprising no excipients.
28. The capsule of claim 26 , wherein said effective amount of binder increases the AUC of pirfenidone upon oral administration at least 60%, as compared to a capsule comprising no excipients.