Silicone rubber exhibiting effective antimicrobial activity
A silicone rubber exhibiting antimicrobial efficacy contains: a) at least one silicone rubber derived from a curable silicone rubber-forming composition; b) at least one silver-containing antimicrobial agent incorporated in silicone rubber (a) in X weight percent amount; and, c) at least one carboxylic acid incorporated in silicone rubber (a) in Y weight percent amount, silver-containing antimicrobial agent (b) when incorporated by itself in silicone rubber (a) in an amount of X+Y weight percent therein and carboxylic acid (c) when incorporated by itself in silicone rubber (a) in an amount of X+Y weight percent therein imparting no significant antimicrobial activity to silicone rubber (a) but in the combination therein of up to X weight percent silver-containing antimicrobial agent (b) and up to Y weight percent carboxylic acid (c) imparting significant antimicrobial activity to silicone rubber (a), such activity being exhibited at the interface of an exposed surface of silicone rubber (a) and a microbe-populated aqueous material in contact therewith.
1 . A silicone rubber exhibiting antimicrobial efficacy which comprises:
a) at least one silicone rubber derived from a curable silicone rubber-forming composition;
b) at least one silver-containing antimicrobial agent incorporated in silicone rubber (a) in X weight percent amount; and,
c) at least one carboxylic acid incorporated in silicone rubber (a) in Y weight percent amount,
silver-containing antimicrobial agent (b) when incorporated by itself in silicone rubber (a) in an amount of X+Y weight percent therein and carboxylic acid (c) when incorporated by itself in silicone rubber (a) in an amount of X+Y weight percent therein imparting no significant antimicrobial activity to silicone rubber (a) but in the combination therein of up to X weight percent silver-containing antimicrobial agent (b) and up to Y weight percent carboxylic acid (c) imparting significant antimicrobial activity to silicone rubber (a), such activity being exhibited at the interface of an exposed surface of silicone rubber (a) and a microbe-populated aqueous material in contact therewith.
2 . The silicone rubber of claim 1 wherein X is a weight percent range selected from the group consisting of 0.1 to 10, 0.2 to 5 and 0.5 to 2 and Y is a weight percent range selected from the group consisting of 0.1 to 5, 0.2 to 3 and 0.5 to 2.
3 . The silicone rubber of claim 1 wherein the curable silicone rubber-forming composition from which silicone rubber (a) is derived is an LSR, RTV or HCE a liquid silicone rubber, room temperature vulcanizable silicone rubber or heat curable silicone elastomer.
4 . The silicone rubber of claim 1 wherein silver-containing antimicrobial agent (b) is at least one member selected from the group consisting of inorganic silver compound, organic silver compound, silver ion-containing glass, silver ion-containing zeolite, silver ion-containing ceramic matrix, colloidal silver, nanosilver and silver alloy.
5 . The silicone rubber of claim 1 wherein silver-containing antimicrobial agent (b) is at least one of nanosilver, silver ion-containing ceramic matrix and silver sodium hydrogen zirconium phosphate.
6 . The silicone rubber of claim 1 wherein carboxylic acid (c) is at least one member selected from the group consisting of aliphatic carboxylic acid, cycloaliphatic carboxylic acid, aromatic carboxylic acid and anhydrides thereof.
7 . The silicone rubber of claim 4 wherein carboxylic acid (c) is at least one member selected from the group consisting of aliphatic carboxylic acid, cycloaliphatic carboxylic acid, aromatic carboxylic acid and anhydrides thereof.
8 . The silicone rubber of claim 6 wherein carboxylic acid (c) is at least one aliphatic carboxylic acid selected from the group consisting of propanoic acid, 2-methylpropanoic acid, hexanoic acid, heptanoic acid, octanoic acid, lauric acid, oleic acid, linoleic acid, linolenic acid, cyclohexanecarboxylic acid, cyclohexylacetic acid, cyclohexenecarboxylic acid, benzoic acid, benzeneacetic acid, propanedioic acid, butanedioic acid, hexanedioic acid, 2-butenedioic acid, acetic anhydride and maleic anhydride.
9 . The silicone rubber of claim 7 wherein carboxylic acid (c) is at least one aliphatic carboxylic acid selected from the group consisting of propanoic acid, 2-methylpropanoic acid, hexanoic acid, heptanoic acid, octanoic acid, lauric acid, oleic acid, linoleic acid, linolenic acid, cyclohexanecarboxylic acid, cyclohexylacetic acid, cyclohexenecarboxylic acid, benzoic acid, benzeneacetic acid, propanedioic acid, butanedioic acid, hexanedioic acid, 2-butenedioic acid, acetic anhydride and maleic anhydride.
10 . The silicone rubber of claim 1 wherein the curable silicone rubber-forming composition from which silicone rubber (a) is derived is a liquid silicone rubber, room temperature vulcanizable silicone rubber or heat curable silicone elastomer, silver-containing antimicrobial agent (b) is at least one member selected from the group consisting of inorganic silver compound, organic silver compound, silver ion-containing glass, silver ion-containing zeolite, silver ion-containing ceramic matrix, colloidal silver, nanosilver and silver alloy, carboxylic acid (c) is at least one member selected from the group consisting of aliphatic carboxylic acid, cycloaliphatic carboxylic acid, aromatic carboxylic acid and anhydrides thereof, X is a weight percent range selected from the group consisting of 0.1 to 10, 0.2 to 5 and 0.5 to 2 and Y is a weight percent range selected from the group consisting of 0.1 to 5, 0.2 to 3 and 0.5 to 2.
11 . An article made from, or having as a component thereof, the silicone rubber of claim 1 .
12 . An article made from, or having as a component thereof, the silicone rubber of claim 2 .
13 . An article made from, or having as a component thereof, the silicone rubber of claim 3 .
14 . An article made from, or having as a component thereof, the silicone rubber of claim 4 .
15 . An article made from, or having as a component thereof, the silicone rubber of claim 6 .
16 . An article made from, or having as a component thereof, the silicone rubber of claim 10 .
17 . A process of imparting efficacious antimicrobial activity to a silicone rubber (a) derived from a curable silicone rubber-forming composition which comprises:
a) incorporating in the curable silicone rubber-forming composition X weight percent of at least one silver-containing antimicrobial agent (b) and Y weight percent of at least one carboxylic acid (c); and,
b) curing the curable silicone rubber-forming composition to provide silicone rubber (a), silver-containing antimicrobial agent (b) when incorporated by itself in the rubber-forming composition in an amount of X+Y weight percent therein and carboxylic acid
(c) when incorporated by itself in the rubber-forming composition in an amount of X+Y weight percent therein imparting no significant antimicrobial activity to silicone rubbers (a) obtained from the curing of the rubber-forming compositions but in the combination of up to X weight percent silver-containing antimicrobial agent (b) and up to Y weight percent carboxylic acid in the rubber-forming composition, imparting significant antimicrobial activity to silicone rubber (a) obtained therefrom, such activity being exhibited at the interface of an exposed surface of silicone rubber (a) and a microbe-populated aqueous material in contact therewith.
18 . The process of claim 17 wherein X is a weight percent range selected from the group consisting of 0.1 to 10, 0.2 to 5 and 0.5 to 2 and Y is a weight percent range selected from the group consisting of 0.1 to 5, 0.2 to 3 and 0.5 to 2.
19 . The process of claim 17 wherein the curable silicone rubber-forming composition from which silicone rubber (a) is derived is a liquid silicone rubber, room temperature vulcanizable silicone rubber or heat curable silicone elastomer.
20 . A silicone rubber obtained by the process of claim 17 .