Parenteral solutions containing metolazone
Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in N,N-dimethylactamide, polyethylene glycol and D 5 W useful in the treatment of hypertension, heart failure and renal disease leading to edematous states. Also disclosed are methods for preparing such solutions.
1. A solution suitable for parenteral administration, comprising: 1 to 15 mg/mL metolazone dissolved in up to 2% by volume N,N-dimethylacetamide (DMAC) and the reminder of the solution being 5% dextrose (D 5 W), wherein the pH of the solution is from 6.8-8.
2. The solution of claim 1 , wherein the pH of the solution is from 7.5-8.
3. The solution of claim 1 , wherein the metolazone is dissolved in 1% by volume DMAC, and the remainder being D 5 W.
4. The solution of claim 1 , wherein the metolazone is dissolved in 2% by volume DMAC, and the remainder being D 5 W.
5. The solution of claim 1 , wherein 5 mg/mL of metolazone is present.
6. The solution of claim 1 , wherein 15 mg/mL of metolazone is present.
7. The solution of claim 1 , wherein 5 mg/mL of metolazone is present and dissolved in 1% by volume DMAC and the remainder being D 5 W.
8. The solution of claim 7 , wherein the pH is 7.5-8.
9. The solution of claim 1 , wherein 15 mg/mL of metolazone is present and dissolved in 1% by volume DMAC and the remainder being D 5 W.
10. The solution of claim 9 , wherein the pH is 7.5-8.
11. The solution of claim 1 , wherein 5 mg/mL of metolazone is present and dissolved in 2% by volume DMAC and the remainder being D 5 W.
12. The solution of claim 11 , wherein the pH is 6.8.
13. A method of treating hypertension, comprising: parenterally administering a therapeutically effective amount of a solution, comprising: 1 to 15 mg/mL metolazone dissolved in up to 2% by volume N,N-dimethylacetamide (DMAC) and the reminder of the solution being 5% dextrose (D 5 W), wherein the pH of the solution is from 6.8-8.
14. The method of claim 13 , wherein the pH of the solution is from 7.5-8.
15. The method of claim 13 , wherein 5 mg/mL of metolazone is present and dissolved in 1% by volume DMAC and the remainder being D 5 W and the pH is 7.5-8.
16. The method of claim 13 , wherein 15 mg/mL of metolazone is present and dissolved in 1% by volume DMAC and the remainder being D 5 W and the pH is 7.5-8.
17. The method of claim 13 , wherein 5 mg/mL of metolazone is present and dissolved in 2% by volume DMAC and the remainder being D 5 W and the pH is 6.8.