IP Library › Granted Patent US 7,662,624
Granted Patent B2
US 7,662,624 · App. 12/077,575 · Granted Feb 16, 2010

Metal-binding therapeutic peptides

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Quick Facts
Patent No.
US 7,662,624
App. No.
12/077,575
Granted
Feb 16, 2010
Kind
B2
Abstract

The present invention is related methods of delivering MBD peptide-linked agents into live cells. The methods described herein comprise contacting MBD peptide-linked agents to live cells under a condition of cellular stress. The methods of the invention may be used for therapeutic or diagnostic purposes.

Claims (32)

1. A polypeptide comprising the amino acid sequence ETFSDVWKLLKKGFYKKKQCRPSKGRKRGFCWAALDWSWLQT (SEQ ID NO: 220).

2. A composition comprising the polypeptide of claim 1 and a pharmaceutical excipient.

3. A nucleic acid encoding the polypeptide of claim 1 .

4. A vector comprising the nucleic acid of claim 3 .

5. A polypeptide comprising the amino acid sequence ETFSDIWKILLKKGFYKKKQCRPSKGRKRGFCWAALDWSWLQT (SEQ ID NO: 221).

6. A composition comprising the polypeptide of claim 5 and a pharmaceutical excipient.

7. A nucleic acid encoding the polypeptide of claim 5 .

8. A vector comprising the nucleic acid of claim 7 .

9. A polypeptide comprising the amino acid sequence ETFSDVWKLLKKGFYKKKQCRPSKGRKRGFCWAVAEYAWVQKRK (SEQ ID NO: 224).

10. A composition comprising the polypeptide of claim 9 and a pharmaceutical excipient.

11. A nucleic acid encoding the polypeptide of claim 9 .

12. A vector comprising the nucleic acid of claim 11 .

13. A polypeptide comprising the amino acid sequence ETFSDIWKLLKKGFYKKKQCRPSKGRKRGFCWAVAEYAWVQKRK (SEQ ID NO: 225).

14. A composition comprising the polypeptide of claim 13 and a pharmaceutical excipient.

15. A nucleic acid encoding the polypeptide of claim 13 .

16. A vector comprising the nucleic acid of claim 15 .

17. A polypeptide comprising the amino acid sequence HESRGVTEDYLRLETLVQKVVGFYKKKQCRPSKGRKRG FCW (SEQ ID NO: 265).

18. A composition comprising the polypeptide of claim 17 and a pharmaceutical excipient.

19. A nucleic acid encoding the polypeptide of claim 17 .

20. A vector comprising the nucleic acid of claim 19 .

21. A polypeptide comprising the amino acid sequence GVTEDYLRLETLVQKVVSPYLG FYKKKQCRPSKG RKRGFCW (SEQ ID NO: 266).

22. A composition comprising the polypeptide of claim 21 and a pharmaceutical excipient.

23. A nucleic acid encoding the polypeptide of claim 21 .

24. A vector comprising the nucleic acid of claim 23 .

25. A polypeptide comprising the amino acid sequence LRLETLVQKVVSPYLGTYG LHG FYKKKQCRPSKG RKRGFCW (SEQ ID NO: 267).

26. A composition comprising the polypeptide of claim 25 and a pharmaceutical excipient.

27. A nucleic acid encoding the polypeptide of claim 25 .

28. A vector comprising the nucleic acid of claim 27 .

29. A polypeptide comprising the amino acid sequence RGVTEDYLRLETLVQKVVSKG FYKKKQCRPSKG RKRGFCW (SEQ ID NO: 271).

30. A composition comprising the polypeptide of claim 29 and a pharmaceutical excipient.

31. A nucleic acid encoding the polypeptide of claim 29 .

32. A vector comprising the nucleic acid of claim 31 .

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 2, 2021
From: TRANSPORIN, INC
To: ENMODULIN, INC
Reel/Frame 058769/0528 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 5, 2014
From: ONTHERIX, INC.
To: TRANSPORIN, INC.
Reel/Frame 034169/0975 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 23, 2009
From: MASCARENHAS, DESMOND D.
To: ONTHERIX, INC.
Reel/Frame 023559/0505 →