Novel antibacterial agents
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
1 - 40 . (canceled)
41 . A compound of the formula:
wherein n is 2 to 12,
or a pharmaceutically acceptable salt thereof.
42 . The compound of claim 41 , wherein n is 2, or a pharmaceutically acceptable salt thereof.
43 . The compound of claim 41 , wherein n is 3, or a pharmaceutically acceptable salt thereof.
44 . The compound of claim 41 , wherein n is 4, or a pharmaceutically acceptable salt thereof.
45 . The compound of claim 41 , wherein n is 5, or a pharmaceutically acceptable salt thereof.
46 . The compound of claim 41 , wherein n is 6, or a pharmaceutically acceptable salt thereof.
47 . The compound of claim 41 , wherein n is 7, or a pharmaceutically acceptable salt thereof.
48 . The compound of claim 41 , wherein n is 8, or a pharmaceutically acceptable salt thereof.
49 . The compound of claim 41 , wherein n is 9, or a pharmaceutically acceptable salt thereof.
50 . The compound of claim 41 , wherein n is 10, or a pharmaceutically acceptable salt thereof.
51 . The compound of claim 41 , wherein n is 11, or a pharmaceutically acceptable salt thereof.
52 . The compound of claim 41 , wherein n is 12, or a pharmaceutically acceptable salt thereof.
53 . A pharmaceutical composition comprising a compound of claim 41 , or a pharmaceutically acceptable salt thereof.
54 . A method of treating a bacterial infection, the method comprising administering a compound of claim 41 , or a pharmaceutically acceptable salt thereof, to a mammal having a bacterial infection.