Compositions and methods of producing hybrid antigen binding molecules and uses thereof
View Patent ↗This disclosure relates to hybrid antigen binding molecules including at least two polypeptide chains, with at least one polypeptide chain comprises an antigen binding moiety linked to an amino acid sequence of a subunit of a heterodimeric proteinaceous hormone. Also disclosed are methods of making and using such hybrid antigen binding molecules for diagnosis and/or therapy.
1. An anti-EGFR fusion protein comprising the humanized EGFR-specific antigen binding moiety of SEQ ID NO.: 83 linked to a fusion partner.
2. The anti-EGFR fusion protein of claim 1 comprising the amino acid sequence of SEQ ID NO:84.
3. The anti-EGFR fusion protein of claim 1 comprising the amino acid sequence of SEQ ID NO:85.
4. An anti-EGFR binding protein comprising the amino acid sequence of SEQ ID NO:83 or a EGFR-specific antigen binding moiety thereof.