Inhibition of inflammatory cytokine production with tanshinones
View Patent ↗Provided are methods of attenuating release of a proinflammatory cytokine from a mammalian cell. Also provided are methods of inhibiting or treating an inflammatory cytokine cascade in a mammal. Further provided are methods of treating a mammal at risk for or undergoing sepsis, septicemia, and/or endotoxic shock. Additionally provided are methods of attenuating NO release from a mammalian cell. Also provided are methods of attenuating NO production in a mammal at risk for, or having, a disorder mediated by excessive NO production.
1. A method of treating a mammal at risk for or having sepsis, septicemia, and/or endotoxic shock, the method comprising administering to the mammal a purified tanshinone in a manner effective to reduce or prevent a physiologic effect of the sepsis, septicemia, and/or endotoxic shock, wherein the purified tanshinone is tanshinone IIA sodium sulfonate.
2. The method of claim 1 , wherein the mammal is a human.
3. The method of claim 1 , for treating a mammal at risk for sepsis.
4. The method of claim 1 , for treating a mammal at risk for septicemia.
5. The method of claim 1 , for treating a mammal at risk for endotoxic shock.
6. The method of claim 1 , for treating a mammal having sepsis.
7. The method of claim 1 , for treating a mammal having septicemia.
8. The method of claim 1 , for treating a mammal having endotoxic shock.