Methods for the treatment of senile dementia of the alzheimer's type
The present invention relates to the treatment of Senile Dementia of the Alzheimer's Type (SDAT) by administering to the patient and effective amount of 1-alkyl, 2-acyl-glycerol. A specific 1-alkyl, 2-acyl-glycerol is shown below:
1. A method for the treatment of senile dementia of the Alzheimer's Type (SDAT) by administering to a patient in need thereof a therapeutic effective amount of a 1-alkyl, 2-acyl-glycerol wherein the side chains are:
16:0, 18:0, 18:1, 18:2, or 18:3 as alkyls at the sn-1 position, and
16:0, 18:0, 18:1, 18:2, 18:3, 20:4, 20:5, 20:6, 22:4, 22:5, 22:6, 24:4, 24:5, or 24:6 as acyls at the sn-2 position,
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the side chains are:
16:0 or 18:0 as alkyl at the sn-1 position, and
22:6 as acyl at the sn-2 position.
3. A method for the treatment of senile dementia of the Alzheimer's Type (SDAT) by administering to a patient in need thereof a therapeutic effective amount of a 1-alkyl, 2-acyl-glycerol of the formula:
or a pharmaceutically acceptable salt thereof.