Coatable compositions, coatings derived therefrom and microarrays having such coatings
View Patent ↗Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.
1. A microarray comprising:
a plurality of microneedles extending from a support substrate; and
a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt, wherein the coating is obtainable from a coatable composition comprising 100 parts by weight of at least one active agent and at least 50 parts by weight of at least one biological salt.
2. A microarray according to claim 1 wherein the height of the microneedles is between about 1 μm and about 400 μm.
3. A microarray according to claim 1 wherein the microneedles each have an aspect ratio of at least about 2:1.
4. A microarray according to claim 1 wherein the microneedles each have an aspect ratio of at least about 3:1.
5. A microarray according to claim 1 wherein the microneedles each have an aspect ratio of at least about 5:1.
6. A microarray according to claim 1 wherein the microarray comprises up to 1000 microneedles extending from a support substrate.
7. A microarray according to claim 1 wherein each microneedle comprises a base portion attached to the support substrate and a tip portion distal from the support substrate, the coating being on the tip portion of at least one of the plurality of microneedles.
8. A microarray according to claim 1 wherein the biological salt is selected from monosodium citrate, disodium citrate, trisodium citrate, monopotassium citrate, dipotassium citrate, tripotassium citrate, and combinations of two or more of the foregoing.