Liquid antibacterial compositions incorporating trichlorocarbanilide with reduced water activity
View Patent ↗A liquid antibacterial soap comprising trichlorocarbanilide, wherein the composition includes, 0.1-5 wt. % trichlorocarbanilide, 0-40 wt. % water, 0.1-40 wt. % of a surfactant or mixture of surfactants, 10-60 wt. % of lower glycols to render the composition visually clear and stable, and 0.1-10 wt. % of a mixture of additional adjuvant ingredients.
1. A liquid antibacterial composition comprising:
3,4,4′- trichlorocarbanilide present in an amount from about 0.01 to about 10 weight percent of said liquid antibacterial composition;
water present in an amount from about 3 to about 20 weight percent of said liquid antibacterial composition;
one or more surfactants present in an amount from about 0.1 to about 40 weight percent of said liquid antibacterial composition;
one or more co-solvents present in an amount from about 10 to about 60 weight percent of said liquid antibacterial composition; and
optionally one or more ingredients selected from a group comprising: fragrances, polymers, preservatives, skin care aids, dyes, pH adjusters, chelating agents, stabilizers and combinations thereof, present in an amount from about 0.1 to about 10 weight percent of said liquid antibacterial composition.
2. The liquid antibacterial composition of claim 1 , wherein said trichlorcarbanilide is present in an amount from about 0.05 to about 7.5 weight percent of said liquid antibacterial composition.
3. The liquid antibacterial composition of claim 2 , wherein said trichlorcarbanilide is present in an amount from about 0.1 to about 5 weight percent of said liquid antibacterial composition.
4. The liquid antibacterial composition of claim 1 , wherein said surfactant is selected from a group comprising: ammonium lauryl sulfate, sodium lauryl ether sulfate, sodium lauryl sulfosuccinate, betaines, amino oxides and combinations thereof.
5. The liquid antibacterial composition of claim 1 , wherein said co-solvent is a lower glycol.
6. The liquid antibacterial composition of claim 5 , wherein said lower glycol is selected from a group comprising: dipropylene glycol, ethoxydiglycol, PEG-8, propylene glycol and combinations thereof.
7. The liquid antibacterial composition of claim 1 comprising a pH from about 4 to about 9.
8. The liquid antibacterial composition of claim 7 comprising a pH from about 5 to about 8.
9. The liquid antibacterial composition of claim 8 comprising a pH from about 5.5 to about 7.5.
10. The liquid antibacterial composition of claim 1 , wherein the composition exhibits a log reduction against Gram-positive bacteria of a least 2.
11. The liquid antibacterial composition of claim 10 , wherein the composition exhibits a log reduction against Gram-positive bacteria of a least 3.
12. The liquid antibacterial composition of claim 1 , wherein the composition exhibits a log reduction against Gram-negative bacteria of a least 2.
13. The liquid antibacterial composition of claim 12 , wherein the composition exhibits a log reduction against Gram-negative bacteria of a least 3.
14. The liquid antibacterial composition of claim 1 , wherein the composition exhibits a log reduction against Gram-positive bacteria of a least 3 after 30 seconds of contact at 40° C. as measured against Staph aureus as measured in a time kill test.
15. The liquid antibacterial composition of claim 1 , wherein the composition exhibits a log reduction against Gram-negative bacteria of a least 1 after 30 seconds of contact at 40° C. as measured against E coli as measured in a time kill test.
16. The liquid antibacterial composition of claim 1 , wherein the composition exhibits a log reduction against Gram-positive bacteria of a least 2 after 30 seconds of contact at 40° C. as measured against S. epidermidis as measured in a time kill test.
17. The liquid antibacterial composition of claim 1 , wherein the composition exhibits a log reduction against Gram-positive bacteria of a least 2 after 30 seconds of contact at 40° C. as measured against MRSA as measured in a time kill test.