Metronidazole cocrystals and imipramine cocrystals
View Patent ↗Cocrystals of metronidazole are described herein. Such cocrystals are a cocrystal of metronidazole with gentisic acid and a cocrystal of metronidazole with gallic acid. Cocrystals of imipramine hydrochloride are also described. Such cocrystals are a cocrystal of imipramine hydrochloride with (+)-camphoric acid, a cocrystal of imipramine hydrochloride with fumaric acid, and a cocrystal of imipramine hydrochloride with 1-hydroxy-2-naphthoic acid.
1. A cocrystal of metronidazole and gentisic acid having about a 1:1 molar ratio of metronidazole to gentisic acid in the unit cell and an x-ray diffracton peak at about 14.5 °2θ.
2. The cocrystal of metronidazole and gentisic acid of claim 1 having substantially the same x-ray diffraction pattern as FIG. 1 .
3. A cocrystal of metronidazole and gentisic acid having about a 1:1 molar ratio of metronidazole to gentisic acid in the unit cell and a Raman peak at about 1189.7 cm −1 .
4. The cocrystal metronidazole and gentisic acid of claim 3 having a Raman spectrum substantially the same as FIG. 5 .
5. A cocrystal of metronidazole and gallic acid having about a 1:1 molar ratio of metronidazole to gallic acid in the unit cell and an x-ray powder diffraction peak at about 15.2 °2θ.
6. The cocrystal of metronidazole and gallic acid of claim 5 having an x-ray powder diffraction pattern that is substantially the same as FIG. 6 .
7. A cocrystal of metronidazole and gallic acid having about a 1:1 molar ratio of metronidazole to gallic acid in the unit cell and a Raman peak at 1493.5 cm −1 .
8. The cocrystal of metronidazole and gallic acid of claim 7 having a Raman spectrum substantially the same as that of FIG. 8 .
9. A cocrystal of imipramine hydrochloride and (+)-camphoric acid having about a 1:1 molar ratio of imipramine hydrochloride to (+)-camphoric acid in the unit cell and an x-ray powder diffraction peak at about 5.4 °2θ.
10. The cocrystal of imipramine hydrochloride and (+)-camphoric add of claim 9 having substantially the same x-ray powder diffraction pattern of FIG. 9 .
11. A cocrystal of imipramine hydrochloride and (+)-camphoric add having about a 1:1 molar ratio of imipramine hydrochloride to (+)-camphoric acid in the unit cell and a Raman peak at about 1059.1 cm −1 .
12. The cocrystal of imipramine hydrochloride and (+)-camphoric acid of claim 11 having a Raman spectrum substantially the same as that of FIG. 15 .
13. A pharmaceutical composition comprising a 1:1 cocrystal of metronidazole and gentisic acid having an x-ray diffraction peak at about 14.5 °2θ and one or more pharmaceutically acceptable carrier.
14. A pharmaceutical composition comprising a 1:1 cocrystal of metronidazole and gallic acid having an x-ray powder diffraction peak at about 15.2 °2θ and one or more pharmaceutically acceptable carrier.
15. A pharmaceutical composition comprising a 1:1 cocrystal of imipramine hydrochloride and (+)-camphoric acid having an x-ray powder diffraction peak at about 5.4 °2θ and one or more pharmaceutically acceptable carrier.