Compounds for modulating T-cells
Disclosed are compounds and compositions that modulate T-cells. Such compounds can be used to treat T-cell mediated disease like T-ALL, rheumatoid arthritis, multiple sclerosis, and graft-vs-host disease (GvHD), to name but a few. The compounds have a general structure as shown in Formula I. Ar 1 -L-Ar 2 I wherein Ar 1 and Ar 2 , are independent of one another, a substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl; and L is a bond or a linker spanning two, three, four, or five atoms.
1. A method of modulating T-cell activity, comprising administering to a subject diagnosed with T-cell acute lymphocytic leukemia (T-ALL) a composition comprising a therapeutically effective amount of a compound having a formula:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the composition is administered prior to treatment with an approved chemotherapeutic agent.
3. The method of claim 1 , wherein the subject has been diagnosed with a T-cell acute lymphocytic leukemia (T-ALL) prior to administration.
4. The method of claim 1 , further comprising the step of identifying in the subject a need for treatment of a T-cell acute lymphocytic leukemia (T-ALL).
5. The method of claim 1 , further comprising the step of treatment with an approved chemotherapeutic agent.
6. The method of claim 1 , wherein administration is performed within one week of T-ALL diagnosis.
7. The method of claim 1 , wherein administration is performed as an alternative to conventional chemotherapy.
8. The method of claim 1 , wherein the subject is human.
9. The method of claim 1 , wherein the diagnosed T-ALL is refractory T-ALL or relapsed T-ALL.
10. The method of claim 1 , wherein the subject is also in need for treatment for one or more of rheumatoid arthritis, multiple sclerosis, and graft-vs-host disease (GvHD).
11. The method of claim 1 , wherein the composition further comprises one or more additional active ingredients selected from antimicrobial agents, anti-inflammatory agents, and anesthetics.
12. The method of claim 1 , wherein administration is oral administration.
13. The method of claim 1 , wherein administration is performed intravenously, intraperitoneally, intramuscularly, subcutaneously, intracavity, or transdermally.
14. The method of claim 1 , wherein the compound is present in the forma of a pharmaceutically acceptable salt.