Intragastric Volume-Occupying Device
An intragastric device having a non-degradable porous membrane enclosing a material which expands upon contact with fluid, and causes the volume of the device to increase is described. The intragastric device is useful for managing satiety and weight loss.
1 . An intragastric device comprising a non-degradable porous membrane enclosing a material which expands upon contact with fluid, and causes the volume of the device to increase.
2 . The intragastric device of claim 1 wherein the non-degradable porous membrane is water permeable.
3 . An intragastric device of claim 1 wherein said device is sized to be delivered orally.
4 . An intragastric device of claim 2 wherein said device is sized to be delivered orally via a swallowable capsule.
5 . The intragastric device of claim 1 further comprising at least one controlled deactivation means.
6 . An intragastric device of claim 1 wherein the non-degradable porous membrane maintains a constant relative pore size during expansion of the material.
7 . An inflatable gastric device comprising a non-degradable fibrillated membrane enclosing an expandable material wherein the expandable material causes the device to expand upon contact with gastric liquids.
8 . An inflatable gastric device of claim 7 wherein said inflatable gastric device is sized to be delivered orally.
9 . An inflatable gastric device of claim 6 wherein said fibrillated membrane is not disruptable under physiological conditions for a period of at least ten days.
10 . The inflatable gastric device of claim 6 further comprising a rupture valve.
11 . An intragastric device comprising:
a. a non-degradable porous membrane, and
b. a swellable material enclosed within the porous membrane to form an initial shape wherein said initial shape expands to an expanded volume upon contact with liquids to form a final shape.
12 . The intragastric device of claim 11 wherein the final shape has at least 5 times volume of initial shape.
13 . The intragastric device of claim 11 wherein the final shape has about 2-3000 times volume of initial shape.
14 . The intragastric device of claim 11 wherein the initial shape has volume between 0.1 ml to 28 ml.
15 . The intragastric device of claim 11 wherein the initial shape has volume between 0.5 ml to 10 ml.
16 . The intragastric device of claim 11 wherein the final shape has volume between 20 ml to 1500 ml.
17 . The intragastric device of claim 11 wherein the final shape has volume between 100 ml to 500 ml.
18 . The intragastric device of claim 11 wherein said initial shape is selected from kidney, oblong, cylindrical, oval, rectangular, ellipse, triangle, conical, trapezoidal, star-like, pear-like, umbrella-like, butterfly, bow-tie, snare-like, coil, helical, spiral, doughnut, or spherical shape configuration.
19 . The intragastric device of claim 11 wherein the final shape is selected from kidney, oblong, cylindrical, oval, rectangular, ellipse, triangle, conical, trapezoidal, star-like, pear-like, umbrella-like, butterfly, bow-tie, snare-like, coil, helical, spiral, doughnut, or spherical shape configuration.
20 . The intragastric device of claim 11 wherein said final shape has a different configuration than said initial shape.
21 . The intragastric device of claim 11 further comprising a contrast agent.
22 . The intragastric device of claim 11 wherein a portion of the device is radiopaque.
23 . An intragastric device comprising:
a. at least one non-degradable porous membrane,
b. a swellable material enclosed within the at least one porous membrane to form multiple units, and
c. non-degradable outer shell membrane which contains the multiple units.