Methods of inhibiting the growth of onychomycosis and urushiol-induced allergic contact dermatitis

1. A method of treating onychomycosis and/or urashiol-induced contact dermatitis comprising topically applying a composition comprising

(i) a primary diamine comprising a polyether segment;

(ii) a secondary aromatic diamine;

(iii) a polyisocyanate; and

(iv) optionally, a polyol,

and/or a reaction product thereof.

2. The method of claim 1 , wherein topically applying the composition comprises

forming a solution comprising the primary diamine, the secondary aromatic diamine, the polyisocyanate, and optionally, the polyol; and/or a reaction product thereof; and

coating an affected nail or skin with the solution.

3. The method of claim 2 , wherein topically applying the composition further comprises drying the solution to form a polyurea, and/or polyureathane polymer.

4. The method of claim 3 , wherein the primary diamine comprises polyoxypropylenediamine.

5. The method of claim 3 , wherein the secondary aromatic diamine comprises N,N′-dialkylaminodiphenylmethane.

6. The method of claim 5 , wherein the secondary aromatic diamine comprises bis(sec-butylamino)diphenylmethane.

7. The method of claim 3 , wherein the polyisocyanate comprises at least one of diphenymethanediisocyanate (MDI), a polyisocyanate, MDI containing resin, aliphatic diisocyanates, aromatic diisocyanates, alicyclic diisocyanates, ethylene diisocyanate, ethylidene diisocyanate, propylene diisocyanaie, butylene diisocyanate, cyclopentylene-1,3-diisocyanate, cyclohexylene-1,4,diisocyanate, cyclohexylene-1,2-diisocyanate, 2,4-tolylene diisocyanate, 2,6-tolylene diisocyanate, 4,4′-diphenylmethane diisocyanate, 2,2-diphenylpropane-4,4′-diisocyanate, p-phenylene diisocyanate, m-phenylene diisocyanate, xylylene diisocyanate, 1,4-naphthylene diisocyanate, 1,5-naphthylene diisocyanate, diphenyl-4,4′-diisocyanate, azobenzene-4,4′diisocyanate, diphenylsulfone-4,4′diisocyanate, dichlorohexamethylene diisocyanate, tetramethylene diisocyanate, pentamethylene diisocyanate, hexamethylene diisocyanate, 1-chlorobenzene-2,4-diisocyanate, furfurylidene diisocyanate and triphenylmethane triisocyanate.

8. The method of claim 7 , wherein the polyisocyanate comprises MDI, a polyisocyanate adduct and/or a MDI containing resin.

9. The method of claim 8 , wherein the polyisocyanate comprises a carbodiimide modified MDI.

10. The method of claim 3 , wherein the polyol comprises at least one of ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, 2,3-butylene glycol, a propylene oxide adduct of trimethylol propane, polyethylene glycol.

11. The method of claim 10 , wherein the polyol comprises at least one of ethylene glycol, propylene glycol and a propylene oxide adduct of trimethylol propane.

12. The method of claim 1 , wherein the composition further comprises at least one solvent selected from the group consisting of acetone, methyl ethyl ketone, methylisobutylketone, N-methylcyclohexanone, acetaldehyde, propionaldehyde, butyraldehyde, isobutyraldehyde, methyl acetate, ethyl acetate, butyl acetate, and methyl propyl acetate.

13. The method of claim 1 , wherein the volume ratio of the primary diamine ranges from about 3.6% to about 12.2% v/v, based on the total volume of the composition.

14. The method of claim 1 , wherein the volume ratio of the secondary aromatic diamine ranges from about 0.6% to about 6.8% v/v, based on the total volume of the composition.

15. The method of claim 1 , wherein the ratio of the primary and secondary diamine to the polysicoyanate is from about 2.8:1 to about 3.8:1 by volume.

16. The method of claim 1 , wherein the composition further comprises a colorant and/or pigment.