IP Library Granted Patent US 9,427,285
Granted Patent B2
US 9,427,285 · App. 12/107,025 · Granted Aug 30, 2016

Systems and methods for creating an effect using microwave energy to specified tissue

Inventors: Mark E. Deem (Moutain View, CA); Dan Francis (Mountain View, CA); Jessi Ernest Johnson (Mountain View, CA); Steven Kim (Los Altos, CA); Alexey Salamini (San Francisco, CA); Ted Su (Sunnyvale, CA); Peter Smith (Kirkcaldy, GB); Dan Hallock (Redwood City, CA)
Assignee: MIRAMAR LABS, INC.
A61B18/1815A61B18/18A61N5/02A61B2018/00005A61B2018/00023A61B2018/00029A61B2018/00041A61B2018/00291A61F2007/0075
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Quick Facts
Patent No.
US 9,427,285
App. No.
12/107,025
Granted
Aug 30, 2016
Kind
B2
Abstract

Systems, methods and devices for creating an effect using microwave energy to specified tissue are disclosed. A system for the application of microwave energy to a tissue includes a signal generator adapted to generate a microwave signal having predetermined characteristics, an applicator connected to the generator and adapted to apply microwave energy to tissue. The applicator includes one or more microwave antennas and a tissue interface, a vacuum source connected to the tissue interface, a cooling source connected to the tissue interface, and a controller adapted to control the signal generator, the vacuum source, and the coolant source. The tissue includes a first layer and a second layer, the second layer below the first layer. The controller is configured so that the system delivers energy such that a peak power loss density profile is created in the second layer.

Claims (25)

1. A system for the application of microwave energy to skin, comprising:

a signal generator adapted to generate a microwave signal having an electric field component;

an applicator comprising one or more microwave antennas and a tissue interface, the applicator connected to the signal generator and adapted to apply the microwave signal to the skin, wherein the microwave signal has an electric field component;

a tissue chamber adapted to move a skin surface into thermal contact with a cooling plate in the tissue interface, the cooling plate being oriented with respect to the antenna so as to be parallel with the electrical field component of the microwave signal;

a vacuum source connected to the tissue chamber;

a coolant source connected to said tissue interface and adapted to cool skin in thermal contact with the tissue interface; and

a controller adapted to control the signal generator, the vacuum source, and the coolant source, wherein the one or more of the microwave antennas is configured to radiate the microwave energy into the skin, the microwave energy having a frequency and electric field orientation which generates a standing wave pattern having a constructive interference peak in a target tissue in the lower portion of the dermal layer of the skin, thereby creating a peak temperature at the target tissue, creating a lesion core;

wherein the coolant source removes heat from the skin surface and at least an upper portion of the dermal skin layer to prevent the heat from spreading into an upper portion of the dermal skin layer;

wherein the controller is configured to stop the application of the microwave energy after a predetermined time sufficient to raise the temperature of the tissue structure; and

wherein the microwave signal has a frequency in the range of: between about 5 GHz and about 6.5 GHz.

2. The system of claim 1 , wherein the controller is configured such that the system delivers energy such that a power loss density peak is created in the target tissue.

3. The system of claim 1 , wherein the standing wave pattern is created by the reflection of at least a portion of the microwave energy off an interface between the dermal skin layer and the sub-dermal skin layer.

4. The system of claim 1 , wherein the target tissue is in the glandular layer and the standing wave pattern is created by the reflection of at least a portion of the microwave energy off an interface between the glandular layer and the sub-dermal skin layer.

5. The system of claim 1 , wherein the glandular layer comprises sweat glands.

6. The system of claim 1 , wherein the target tissue comprises a sweat gland.

7. The system of claim 1 , wherein the target tissue comprises a hair follicle.

8. A method of improving skin tissue by raising the temperature of a tissue structure, the method comprising the steps of:

positioning a device adapted to radiate microwave energy adjacent an external surface of the skin;

moving the skin surface into a vacuum chamber of the device to a position parallel to an output of a microwave antenna of the device;

radiating microwave energy having a frequency of approximately 5.8 GHz and an electric field component which is substantially parallel to a region of the external surface of the skin, wherein the microwave energy has a frequency and e-field orientation which generates a standing wave pattern in a target tissue in the lower portion of the dermal layer of the skin by the reflection of at least a portion of the microwave energy off the interface between the dermal skin layer and the sub-dermal skin layer, the standing wave pattern having a constructive interference peak in the target tissue, thereby creating a peak temperature at the target tissue using the radiated microwave energy, creating a lesion core; and

removing heat from the skin surface and an upper portion of the dermal skin layer to prevent heat from spreading into an upper portion of the dermal skin layer.

9. The method of claim 8 , wherein the target tissue is in a glandular layer and the standing wave pattern is created by the reflection of at least a portion of the microwave energy off an interface between the glandular layer and the sub-dermal skin layer.

10. The method of claim 9 , wherein the glandular layer comprises sweat glands.

11. The method of claim 8 , wherein the target tissue comprises a sweat gland and wherein the method further comprises the step of radiating microwave energy to allow preferential heating of sweat glands.

12. The system of claim 8 , wherein the tissue structure comprises a hair follicle.

Assignments (19)
SECURITY INTEREST Recorded Oct 1, 2024
From: MIRADRY, INC.
To: WESTERN ALLIANCE BANK
Reel/Frame 068752/0533 →
RELEASE OF SECURITY INTEREST Recorded Nov 22, 2022
From: MIDCAP FUNDING IV TRUST
To: SIENTRA, INC.; MIST HOLDINGS, INC.; MIST, INC.; MIST INTERNATIONAL, INC.
Reel/Frame 061983/0486 →
RELEASE OF SECURITY INTEREST Recorded Nov 22, 2022
From: MIDCAP FINANCIAL TRUST
To: SIENTRA, INC.; MIST HOLDINGS, INC.; MIST, INC.; MIST INTERNATIONAL, INC.
Reel/Frame 061983/0573 →
RELEASE OF SECURITY INTEREST (TERM) Recorded Jun 22, 2021
From: MIDCAP FINANCIAL TRUST
To: MIRADRY HOLDINGS, INC.; MIRADRY, INC.; MIRADRY INTERNATIONAL, INC.
Reel/Frame 056648/0044 →
RELEASE OF SECURITY INTEREST (REVOLVING) Recorded Jun 22, 2021
From: MIDCAP FUNDING IV TRUST
To: MIRADRY HOLDINGS, INC.; MIRADRY, INC.; MIRADRY INTERNATIONAL, INC.
Reel/Frame 056648/0001 →
SECURITY INTEREST SUPPLEMENT (REVOLVING) Recorded Feb 23, 2021
From: SIENTRA, INC.; MIRADRY HOLDINGS, INC.; MIRADRY, INC.; MIRADRY INTERNATIONAL, INC.
To: MIDCAP FUNDING IV TRUST, AS AGENT
Reel/Frame 055379/0016 →
REAFFIRMATION AGREEMENT AND AMENDMENT TO SECURITY AGREEMENT (TERM) Recorded Feb 23, 2021
From: SIENTRA, INC.; MIRADRY HOLDINGS, INC.; MIRADRY, INC.; MIRADRY INTERNATIONAL, INC.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 055436/0001 →
SECURITY INTEREST Recorded Jul 2, 2019
From: SIENTRA, INC; MIRADRY HOLDINGS, INC.; MIRADRY, INC; MIRADRY INTERNATIONAL, INC.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 049649/0450 →
SECURITY INTEREST Recorded Jul 2, 2019
From: SIENTRA, INC; MIRADRY HOLDINGS, INC.; MIRADRY, INC; MIRADRY INTERNATIONAL, INC.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 049650/0001 →
SECURITY INTEREST Recorded Mar 13, 2019
From: MIDCAP FUNDING X TRUST (AS SUCCESSOR TO MIDCAP FINANCIAL TRUST)
To: MIDCAP FUNDING IV TRUST, SUCCESSOR AGENT
Reel/Frame 048588/0123 →
CHANGE OF NAME Recorded May 3, 2018
From: MIRAMAR LABS, INC.
To: MIRAMAR TECHNOLOGIES, INC.
Reel/Frame 045706/0690 →
CHANGE OF NAME Recorded May 3, 2018
From: MIRAMAR TECHNOLOGIES, INC.
To: MIRADRY, INC.
Reel/Frame 045707/0330 →
RELEASE OF SECURITY INTEREST Recorded Aug 18, 2017
From: OXFORD FINANCE LLC
To: MIRAMAR TECHNOLOGIES, INC. F/K/A MIRAMAR LABS, INC.
Reel/Frame 043331/0505 →
SECURITY INTEREST Recorded Jul 28, 2017
From: SIENTRA, INC.; MIRAMAR LABS, INC.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 043361/0130 →
SECURITY INTEREST Recorded Jul 28, 2017
From: SIENTRA, INC.; MIRAMAR LABS, INC.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 043362/0811 →
SECURITY INTEREST Recorded Mar 8, 2017
From: MIRAMAR TECHNOLOGIES, INC.
To: OXFORD FINANCE LLC
Reel/Frame 041510/0935 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 26, 2010
From: FOUNDRY, INC., THE
To: MIRAMAR LABS, INC.
Reel/Frame 023868/0143 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 21, 2010
From: THE FOUNDRY, INC.
To: MIRAMAR LABS, INC.
Reel/Frame 023823/0006 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 15, 2009
From: DEEM, MARK E.; FRANCIS, DAN; JOHNSON, JESSI ERNEST; KIM, STEVEN; SALAMINI, ALEXEY; SU, TED; SMITH, PETER; HALLOCK, DAN
To: FOUNDRY, INC., THE; MIRAMAR LABS, INC.
Reel/Frame 022119/0587 →
Continuity (8)
Continuation In Part PCTUS2008060935 · Apr 18, 2008
Continuation In Part PCTUS2008060929 · Apr 18, 2008
Continuation In Part PCTUS2008060940 · Apr 18, 2008
Continuation In Part PCTUS2008060922 · Apr 18, 2008
Provisional Application 60912899 · Apr 19, 2007
Provisional Application 61013274 · Dec 12, 2007
Provisional Application 61045937 · Apr 17, 2008
Related Publication 20080269851A1 · Oct 30, 2008