IP Library › Granted Patent US 7,754,075
Granted Patent B2
US 7,754,075 · App. 12/113,253 · Granted Jul 13, 2010

Backflow prevention for high pressure gradient systems

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Quick Facts
Patent No.
US 7,754,075
App. No.
12/113,253
Granted
Jul 13, 2010
Kind
B2
Abstract

Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention adds sufficient minimum flow resistance, thereby enhancing the performance of the pulse dampening over a wider range of flow rates resulting in consistent gradient performance.

Claims (4)

1. A high pressure liquid chromatography apparatus comprising: a mixing tee having an outlet port, a first inlet port and a second inlet port; and a backflow preventer incorporated within said first and second inlet port said backflow preventer having a coil spring and an actuator seated within a valve seat wherein said coil spring exerts a selected pressure upon said actuator.

2. The high pressure liquid chromatography apparatus according to claim 1 wherein said selected pressure is ranges between 0 and 2000 psi.

3. The high pressure liquid chromatography apparatus according to claim 1 wherein said incorporation reduces system volume.

4. The high pressure liquid chromatography apparatus according to claim 1 wherein said backflow preventer has a selected fixed resistance said selected fixed resistance ensuring that pulse dampeners within a chromatography system function efficiently with consistent performance of primary check valves of system pumps.