Computer aided lesion assessment in dynamic contrast enhanced breast MRI images

1. A method for performing computer-assisted lesion assessment, comprising:

acquiring contrast enhanced MRI data;

identifying a region of interest;

determining kinetic properties, morphological properties and pattern of enhancement for the identified region of interest;

calculating a score for each of the kinetic properties, morphological properties, pattern of enhancement, and a cumulative score for the identified region of interest; and

providing the scores to a medical practitioner to assist in diagnosing the identified region of interest,

wherein determining the pattern of enhancement for the identified region of interest includes assessing a ring-like intensity distribution.

2. The method of claim 1 , wherein determining the morphological properties of the identified region of interest includes:

identifying a boundary of the region of interest;

identifying a core region within the identified boundary of the region of interest; calculating a ring of expansion about the core region; and

determining the morphological properties of the identified region of interest based on the calculated ring of expansion.

3. The method of claim 2 , wherein the steps of identifying a boundary of the region of interest, identifying a core region within the identified boundary of the region of interest, calculating a ring of expansion about the core region, and determining the morphological properties of the identified region of interest based on the calculated ring of expansion are repeated for multiple image slices with the center image slice forming a key segmentation region of the region of interest and the determined morphological properties for each image slice are averaged.

4. The method of claim 1 , wherein the contrast enhanced MRI data is acquired from a breast of a subject.

5. The method of claim 1 , wherein a gadolinium based contrast agent (Gd-DTPA) is used as a contrast agent in acquiring the contrast enhanced MRI data.

6. The method of claim 1 , wherein the kinetic properties score, the morphological properties score, and the pattern of enhancement score are calculated from the determined properties using one or more heuristic rules.

7. A method for performing computer-assisted lesion assessment, comprising:

acquiring contrast enhanced MRI data;

identifying a region of interest;

determining kinetic properties, morphological properties and pattern of enhancement for the identified region of interest;

calculating a score for the kinetic properties, morphological properties, pattern of enhancement, and a cumulative score for the identified region of interest; and

providing the scores to a medical practitioner to assist in diagnosing the identified region of interest,

wherein determining the pattern of enhancement of the identified region of interest includes:

calculating a radius of the region of interest;

calculating a matching template for the region of interest;

identifying a point of highest normalized correlation;

determining a first pattern of enhancement based on the identified point of highest normalized correlation using the calculated matching template; and

determining a second pattern of enhancement by counting a number of connected components greater than a particular size within the region of interest.

8. The method of claim 7 , wherein the steps of calculating a radius of the region of interest, calculating a matching template for the region of interest, identifying a point of highest normalized correlation, determining a first pattern of enhancement, and determining a second pattern of enhancement are repeated for multiple image slices with the center image slice forming a key segmentation region of the region of interest and the patterns of enhancement determined for each image slice are averaged.

9. A method for performing computer-assisted lesion assessment, comprising:

acquiring contrast enhanced MRI data;

identifying a region of interest;

determining kinetic properties, morphological properties and pattern of enhancement for the identified region of interest;

calculating a score for the kinetic properties, morphological properties, pattern of enhancement, and a cumulative score for the identified region of interest; and

providing the scores to a medical practitioner to assist in diagnosing the identified region of interest,

wherein determining kinetic properties includes:

calculating a maximum focal enhancement (MFE) value as a percentage of maximum intensity difference over an average pre-contrast intensity of the contrast enhanced MRI data;

calculating a maximum intensity and time rate (MITR) value as a ratio between maximum intensity difference and a time interval in seconds between contrast administration and a peak time; and

calculating a pattern of washout (POCW) as either:

a pattern of monotonic intensity increase;

a pattern of peak intensity within 3 minutes followed by slow intensity decrease or no intensity decrease; or

a pattern of peak intensity followed by a quick intensity decrease.

10. A system for performing computer-assisted lesion assessment, comprising:

an image volume acquisition unit for acquiring contrast enhanced MRI data;

a display unit for displaying the MRI data;

an input unit for receiving an identification of a region of interest from a user;

an image processing unit for determining kinetic properties, morphological properties and pattern of enhancement for the identified region of interest within the MRI data;

a calculating unit for calculating a score for each of the kinetic properties, morphological properties, pattern of enhancement, and a cumulative score for the identified region of interest; and

an output unit for providing the scores to the user to assist in diagnosing the identified region of interest,

wherein determining the pattern of enhancement for the identified region of interest includes assessing a ring-like intensity distribution.

11. The system of system 10 , wherein the image processing unit:

identifies a boundary of the region of interest;

identifies a core region within the identified boundary of the region of interest;

calculates a ring of expansion about the core region; and

determines the morphological properties of the identified region of interest based on the calculated ring of expansion.

12. The system of claim 11 , wherein the boundary is identified, the core region is identified, the ring of expansion is calculated, and the morphological properties are determined, repeatedly for multiple image slices with the center image slice forming a key segmentation region of the region of interest and the determined morphological properties for each image slice are averaged.

13. The system of claim 10 , wherein the contrast enhanced MRI data is acquired from a breast of a subject.

14. The system of claim 10 , additionally including an administration unit for administering a gadolinium based contrast agent (Gd-DTPA) as a contrast agent in acquiring the contrast enhanced MRI data.

15. A system for performing computer-assisted lesion assessment, comprising:

an image volume acquisition unit for acquiring contrast enhanced MRI data;

a display unit for displaying the MRI data;

an input unit for receiving an identification of a region of interest from a user;

an image processing unit for determining kinetic properties, morphological properties and pattern of enhancement for the identified region of interest within the MRI data

a calculating unit for calculating a score for the kinetic properties, morphological properties, pattern of enhancement, and a cumulative score for the identified region of interest; and

an output unit for providing the scores to the user to assist in diagnosing the identified region of interest,

wherein determining the pattern of enhancement of the identified region of interest includes:

calculating a radius of the region of interest;

calculating a matching template for the region of interest;

identifying a point of highest normalized correlation;

determining a first pattern of enhancement based on the identified point of highest normalized correlation using the calculated matching template; and

determining a second pattern of enhancement by counting a number of connected components greater than a particular size within the region of interest.

16. The system of claim 15 , wherein calculating the radius, calculating the matching template, identifying the point of highest normalized correlation, determining the first pattern of enhancement, and determining the second pattern of enhancement are repeated for multiple image slices with the center image slice forming a key segmentation region of the region of interest and the patterns of enhancement determined for each image slice are averaged.

17. A computer system comprising:

a processor; and

a program storage device readable by the computer system, embodying a program of instructions executable by the processor to perform method steps for performing computer-assisted lesion assessment, the method comprising:

acquiring contrast enhanced MRI data;

identifying a region of interest;

determining kinetic properties, morphological properties and pattern of enhancement for the identified region of interest;

calculating a score for each of the kinetic properties, morphological properties, pattern of enhancement, and a cumulative score for the identified region of interest; and

providing the scores to a medical practitioner to assist in diagnosing the identified region of interest,

wherein determining the pattern of enhancement for the identified region of interest includes assessing a ring-like intensity distribution.

18. The computer system of claim 17 , wherein determining the morphological properties of the identified region of interest includes:

identifying a boundary of the region of interest;

identifying a core region within the identified boundary of the region of interest;

calculating a ring of expansion about the core region; and

determining the morphological properties of the identified region of interest based on the calculated ring of expansion.

19. A computer system comprising:

a processor; and

a program storage device readable by the computer system, embodying a program of instructions executable by the processor to perform method steps for performing computer-assisted lesion assessment, the method comprising:

acquiring contrast enhanced MRI data;

identifying a region of interest;

determining kinetic properties, morphological properties and pattern of enhancement for the identified region of interest;

calculating a score for the kinetic properties, morphological properties, pattern of enhancement, and a cumulative score for the identified region of interest; and

providing the scores to a medical practitioner to assist in diagnosing the identified region of interest,

wherein determining the pattern of enhancement of the identified region of interest includes:

calculating a radius of the region of interest;

calculating a matching template for the region of interest;

identifying a point of highest normalized correlation;

determining a first pattern of enhancement based on the identified point of highest normalized correlation using the calculated matching template; and

determining a second pattern of enhancement by counting a number of connected components greater than a particular size within the region of interest.

20. A computer system comprising:

a processor; and

a program storage device readable by the computer system, embodying a program of instructions executable by the processor to perform method steps for performing computer-assisted lesion assessment, the method comprising:

acquiring contrast enhanced MRI data;

identifying a region of interest;

determining kinetic properties, morphological properties and pattern of enhancement for the identified region of interest;

calculating a score for the kinetic properties, morphological properties, pattern of enhancement, and a cumulative score for the identified region of interest; and

providing the scores to a medical practitioner to assist in diagnosing the identified region of interest,

wherein determining kinetic properties includes:

calculating a maximum focal enhancement (MFE) value as a percentage of maximum intensity difference over an average pre-contrast intensity of the contrast enhanced MRI data;

calculating a maximum intensity and time rate (MITR) value as a ratio between maximum intensity difference and a time interval in seconds between contrast administration and a peak time; and

calculating a pattern of washout (POCW) as either:

a pattern of monotonic intensity increase;

a pattern of peak intensity within 3 minutes followed by slow intensity decrease or no intensity decrease; or

a pattern of peak intensity followed by a quick intensity decrease.