Inhibitors of protein kinases

1. A compound having Formula I

or a therapeutically acceptable salt thereof, wherein

A 1 is C(O)NHR 1 ;

B 1 and C 1 are independently H; wherein

R 1 is R 2 or R 3 ;

R 2 is phenyl;

R 3 is heteroaryl;

wherein R 2 and R 3 are substituted with NHC(O)R 30 , NHC(O)NHR 30 , or alkyl which is substituted with C(O)NHR 35 or NHC(O)NHR 35 ;

R 30 is R 31 , R 32 or R 33 ;

R 31 is phenyl;

R 32 is heteroaryl;

R 33 is cycloalkyl;

R 35 is R 36 or R 37 ;

R 36 is phenyl;

R 37 is heteroaryl;

wherein the moieties represented by R 31 and R 36 are independently unsubstituted or substituted with one or two of independently selected F, Cl, Br, I, CF 3 , OCF 2 , R 45 , or OR 45 ;

R 45 is alkyl which is unsubstituted or substituted with R 50 , F, Cl, Br, I, or OH; and

R 50 is heterocycloalkyl.

2. The compound of claim 1 , wherein R 1 is R 2 .

3. The compound of claim 2 , wherein R 2 is substituted with NHC(O)NHR 30 .

4. The compound of claim 2 , wherein R 2 is substituted with alkyl which is substituted with NHC(O)NHR 35 .

5. The compound of claim 1 , wherein R 1 is R 3 .

6. The compound of claim 2 , wherein R 3 is substituted with NHC(O)NHR 30 .

7. The compound of claim 2 , wherein R 3 is substituted with alkyl which is substituted with NHC(O)NHR 35 .

8. The compound of claim 1 selected from the group consisting of

4-amino-N-(4-((((3-fluorophenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((4-fluorophenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((2-fluorophenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((anilinocarbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((3,5-dimethylphenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((3-methylphenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((4-methylphenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((2-methylphenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((3-methoxyphenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((4-methoxyphenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-(((cyclopropylamino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-(((cyclopentylamino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-(((thien-3-ylamino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-(((pyridin-3-ylamino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-(benzoylamino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((2-fluoro-5-methylphenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((4-(2-hydroxyethyl)phenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((3-(2-hydroxyethyl)phenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((3-(hydroxymethyl)phenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((3-(3-hydroxypropoxy)phenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(3-((anilinocarbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(3-((((3-methylphenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(5-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1,3-thiazol-2-yl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-((((3-(morpholin-4-ylmethyl)phenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-(((((3-methylphenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(4-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(3-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide,

4-amino-N-(3-(((anilinocarbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide

4-amino-N-(3-(((((4-(trifluoromethyl)phenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(3-(((((3,4-difluorophenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(3-(((((4-chloro-2-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(3-(((((3-chlorophenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(3-(((((4-methylphenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(3-(((((4-chlorophenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(3-(((((4-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(3-((((pyridin-3-ylamino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(3-(((((4-(difluoromethoxy)phenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(3-(((((2,4-difluorophenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(3-(((((2,5-difluorophenyl)amino)carbonyl)amino)methyl)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide;

4-amino-N-(4-((((4-chloro-2-fluorophenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide; and

4-amino-N-(4-((((4-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenyl)pyrrolo[2,1-f][2,1,4]triazine-5-carboxamide.

9. A composition comprising an excipient and a therapeutically effective amount of a compound having Formula I of claim 1 .