IP Library Granted Patent US 7,998,117
Granted Patent B2
US 7,998,117 · App. 12/121,545 · Granted Aug 16, 2011

Drug delivery device

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Quick Facts
Patent No.
US 7,998,117
App. No.
12/121,545
Granted
Aug 16, 2011
Kind
B2
Abstract

A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to undergo incremental advancement. The device may also be provided with manual control for delivering a bolus dose of drug when necessary.

Claims (16)

1. A drug delivery device comprising:

(a) a housing containing a drug reservoir;

(b) means for expelling drug from the drug reservoir;

(c) a ratchet mechanism in communication with the expelling means, the ratchet mechanism being operable to undergo incremental advancement and thereby drive the drug from the reservoir in a series of fixed increments, wherein the ratchet mechanism comprises a helical spring having coils, and one or more fingers which make a ratcheting engagement with the coils of the spring;

(d) a member operatively associated with the ratchet mechanism to cause the incremental advancement of said ratchet mechanism as the member moves in a first direction; and

(e) a delivery mechanism located within the housing and operable to expand a chamber, the member being in transmission relation to the chamber, whereby the member is driven by the movement of the chamber to advance the delivery helical spring and thereby drive the drug from the reservoir in the series of fixed increments, each of the fixed increments corresponding to a respective advancement of the ratchet mechanism.

2. The drug delivery device according to claim 1 , wherein the helical spring is caused to advance as the chamber undergoes expansion.

3. The drug delivery device according to claim 1 , wherein one or more fixed fingers are mounted in fixed position relative to the housing, and one or more reciprocable fingers are mounted on the ratchet mechanism, such that when the one or more reciprocable fingers move in a first direction they engage the coils of the helical spring to drive the helical spring in the first direction, and when the one or more reciprocable fingers move in an opposite direction, the one or more fixed fingers engage with and hold the coils of the helical spring preventing it being driven back in a second direction, whereby the fixed and reciprocable fingers co-operate to drive the helical spring in one direction only.

4. The drug delivery device according to claim 3 , wherein one or each of said one or more fixed fingers is inclined in the first direction.

5. The drug delivery device according to claim 3 , wherein the position of the one or more fixed fingers relative to the one or more reciprocable fingers is such that the helical spring is driven by the reciprocable fingers towards the fixed fingers.

6. The drug delivery device according to claim 3 , wherein the minimum distance between the fixed and reciprocable fingers, respectively, is not greater than ten times the distance between adjacent coils of the helical spring when the helical spring is in a relaxed position.

7. The drug delivery device according to claim 6 , wherein the minimum distance between the fixed and reciprocable fingers, respectively, is not greater than five times the distance between adjacent coils of the helical spring when the helical spring is in a relaxed position.

8. The drug delivery device according to claim 7 , wherein the minimum distance between the fixed and reciprocable fingers, respectively, is not greater than twice the distance between adjacent coils of the helical spring when the helical spring is in a relaxed position.

9. The drug delivery device according to claim 8 , wherein the minimum distance between the fixed and reciprocable fingers, respectively, is approximately equal to the distance between adjacent coils of the helical spring when the helical spring is in a relaxed position.

10. The drug delivery device according to claim 1 , wherein the expelling means comprises a piston.

11. The drug delivery device according to claim 1 , wherein the delivery mechanism comprises a gas generator.

Assignments (9)
RELEASE OF PATENT SECURITY AGREEMENT (FIRST LIEN) Recorded Dec 24, 2024
From: MORGAN STANLEY SENIOR FUNDING, INC.
To: ALKERMES, INC.; ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 069771/0548 →
RELEASE BY SECURED PARTY (SECOND LIEN) Recorded Oct 12, 2012
From: MORGAN STANLEY SENIOR FUNDING, INC.
To: ALKERMES, INC.; ALKERMES PHARMA IRELAND LIMITED; ALKERMES CONTROLLED THERAPEUTICS INC.
Reel/Frame 029116/0379 →
CHANGE OF NAME Recorded Sep 4, 2012
From: EDT PHARMA HOLDINGS LIMITED
To: ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 028904/0223 →
NOTICE OF CHANGE IN REGISTERED OFFICE ADDRESS Recorded Sep 4, 2012
From: ALKERMES PHARMA IRELAND LIMITED
To: ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 028904/0244 →
ASSET TRANSFER AGREEMENT Recorded Sep 4, 2012
From: ELAN PHARMA INTERNATIONAL LIMITED
To: EDT PHARMA HOLDINGS LIMITED
Reel/Frame 028904/0163 →
NOTICE OF CHANGE IN REGISTERED OFFICE ADDRESS Recorded Sep 4, 2012
From: EDT PHARMA HOLDINGS
To: EDT PHARMA HOLDINGS
Reel/Frame 028904/0206 →
PATENT SECURITY AGREEMENT (SECOND LIEN) Recorded Sep 29, 2011
From: ALKERMES, INC.; ALKERMES PHARMA IRELAND LIMITED; ALKERMES CONTROLLED THERAPEUTICS INC.
To: MORGAN STANLEY SENIOR FUNDING, INC.
Reel/Frame 026994/0245 →
PATENT SECURITY AGREEMENT (FIRST LIEN) Recorded Sep 29, 2011
From: ALKERMES, INC.; ALKERMES PHARMA IRELAND LIMITED; ALKERMES CONTROLLED THERAPEUTICS INC.
To: MORGAN STANLEY SENIOR FUNDING, INC.
Reel/Frame 026994/0186 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 6, 2011
From: LAVI, GILAD; YIGAL, GIL; CARMEL, EHOUD; TSALS, IZRAIL
To: ELAN PHARMA INTERNATIONAL LIMITED
Reel/Frame 026546/0409 →