Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mGlu2 receptor)

1. A compound of formula I

wherein

X is selected from the group consisting of O, S, S(O), S(O) 2 , NH, NHC(O), and NR x ;

R X is C 1 -C 6 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, C 3 -C 8 -cycloalkyl, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R xa ,

C 1 -C 6 -haloalkyl, C 3 -C 8 -cycloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy,

phenyl, 5- or 6-membered hetaryl having 1, 2 or 3 heteroatoms as ring members, the heteroatoms being selected from the group consisting of O, S, and N, wherein hetaryl and phenyl are unsubstituted or carry 1, 2, 3, 4 or 5 identical or different radicals R xb ,

C(═O)—R x1 , C(═O)—OR x2 , C(═O)NR x3 R x4 , S(O) 2 R x5 or S(O) 2 NR x3 R X4 ; wherein

R x1 is selected from the group consisting of hydrogen, C 1 -C 8 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, C 3 -C 8 -cycloalkyl, and phenyl wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R xa ,

C 1 -C 6 -haloalkyl, C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy,

phenyl, and 5- or 6-membered hetaryl having 1, 2 or 3 heteroatoms as ring members, the heteroatoms being selected from the group consisting of O, S, and N, wherein phenyl and hetaryl are unsubstituted or may carry a fused benzene ring and/or 1, 2, 3, 4 or 5 identical or different radicals R xb ;

R xa is selected from the group consisting of halogen, CN, OH, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy;

R xb is selected from the group consisting of halogen, CN, OH, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy;

R x2 is selected from the group consisting of C 1 -C 3 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, C 3 -C 8 -cycloalkyl, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R xa ,

C 1 -C 8 -haloalkyl, and C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy;

R x3 is selected from the group consisting of hydrogen, C 1 -C 8 alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, C 3 -C 8 -cycloalkyl, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R xa ,

C 1 -C 6 -haloalkyl, C 1 -C 8 alkoxy, C 1 -C 8 haloalkoxy, and C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy;

R x4 is selected from the group consisting of hydrogen and C 1 -C 3 -alkyl, or

R x3 and R x4 together with the nitrogen atom, to which they are bound, form a heterocyclic radical, selected from the group consisting of pyrrolidinyl, piperidinyl, piperazinyl, N-alkylpiperazinyl, N-phenylpiperazinyl, and morpholinyl; and

R x5 has one of the meanings given for R x1 ;

Y is a chemical bond;

A is CR a R b , wherein R a and R b are, independently of each other, selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy; R b may also be OH, if R a is hydrogen, C 1 -C 4 -alkyl, or C 1 -C 4 -haloalkyl;

Ar is phenyl;

R 1 is C(═O)—R 4 ;

R 2 is selected from the group consisting of hydrogen, CN, OH, halogen, C 1 -C 8 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 3 -C 6 -cycloalkyl, and C 1 -C 4 -alkoxy,

C 3 -C 6 -cycloalkyl, C 1 -C 8 -haloalkyl, C 1 -C 8 -alkoxy, and C 1 -C 8 -haloalkoxy;

R 3 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH and C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, and

C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy;

R 4 is selected from the group consisting of

C 3 -C 8 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, C 3 -C 8 -cycloalkyl, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R 4a ,

C 1 -C 8 -haloalkyl,

C 2 -C 8 -alkenyl,

C 2 -C 8 -alkynyl,

C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy,

phenyl, which is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R 4b , and

5- or 6-membered hetaryl having 1, 2 or 3 heteroatoms as ring members, the heteroatoms being selected from the group consisting of O, S, and N, wherein hetaryl is unsubstituted or carries 1, 2, 3 or 4 identical or different radicals R 4b , or

R 4 together with R 2 forms a C 1 -C 5 -alkylene or C 2 -C 5 -alkenylene moiety, wherein one CH 2 -moiety may be replaced by oxygen, sulphur or a N—R 4c -moiety and wherein C 1 -C 5 -alkylene and C 2 -C 5 -alkenylene may be unsubstituted or carry 1, 2, 3, or 4 radicals selected from the group consisting of halogen, CN, OH, NH 2 , C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkylamino, di-(C 1 -C 4 -alkyl)amino, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy;

R 4a is selected from the group consisting of halogen, CN, OH, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy;

R 4b is selected from the group consisting of halogen, CN, OH, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy;

R 4c is selected from the group consisting of hydrogen, CN, OH,

C 1 -C 8 -alkyl, which is unsubstituted or carries a radical selected from the group consisting of C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio, C 1 -C 4 -haloalkoxy, C 1 -C 4 -haloalkylthio, C 3 -C 6 -cycloalkyl, which is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals selected from the group consisting of halogen and C 1 -C 4 -alkyl, and

phenyl or benzyl, wherein the phenyl ring in the last two radicals itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals selected from the group consisting of halogen, CN, OH, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy,

C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy;

Het is pyrazolyl, wherein Het is unsubstituted or may carry a first substituent R 10 and additionally may carry 1 or 2 further substituents selected from the group consisting of R 11 , and R 12 ;

R 10 is selected from the group consisting of halogen, cyano,

C 1 -C 8 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R 4a ,

C 1 -C 8 -alkoxy, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R 4a ,

C 1 -C 8 -haloalkyl,

C 1 -C 8 -haloalkoxy,

C 2 -C 8 -alkenyl,

C 2 -C 8 -alkynyl,

C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy,

C 3 -C 8 -cycloalkoxy, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy,

C(═O)—R 13 , C(═O)—OR 14 , NR 15 R 16 , C(═O)NR 15 R 16 , SO 2 R 17 ,

phenyl, O-phenyl, CH 2 -phenyl, CH(CH 3 )-phenyl, CH(OH)phenyl, S-phenyl, O—CH 2 -phenyl, wherein the phenyl ring in the last seven mentioned radicals may be unsubstituted or may carry 1, 2, 3, 4 or 5 substituents selected from the group consisting of halogen, CN, OH, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy, and

5- or 6-membered heteroaryl, having 1, 2, or 3 heteroatoms as ring members, the heteroatoms being selected from the group consisting of O, S, and N, which is unsubstituted or may carry 1, 2, 3, 4 or 5 substituents selected from the group consisting of halogen, CN, OH, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy;

R 11 is selected from the group consisting of CN, OH, halogen, C 1 -C 8 alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH and C 1 -C 4 -alkoxy, C 1 -C 8 -haloalkyl, C 1 -C 8 -alkoxy, C 1 -C 8 -haloalkoxy, and phenyl, which may be unsubstituted or may carry 1, 2, 3, 4, or 5 substituents selected from the group consisting of halogen, CN, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy;

R 12 is selected from the group consisting of CN, OH, halogen, C 1 -C 8 -alkyl, which is unsubstituted or carries one radical selected from OH and C 1 -C 4 -alkoxy, C 1 -C 8 -haloalkyl, C 1 -C 8 -alkoxy, and C 1 -C 8 -haloalkoxy, or

R 11 and R 12 together with the carbon atom, to which they are bound, form a carbonyl group;

R 13 is selected from the group consisting of hydrogen,

C 1 -C 8 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R 13a ,

C 1 -C 8 -haloalkyl,

C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy,

phenyl, and 5- or 6-membered hetaryl having 1, 2 or 3 heteroatoms as ring members, the heteroatoms being selected from the group consisting of O, S, and N, wherein phenyl and hetaryl are unsubstituted or carry 1, 2, 3, 4 or 5 identical or different radicals R 13b ;

R 13a is selected from the group consisting of halogen, CN, OH, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy;

R 13b is selected from the group consisting of halogen, CN, OH, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy;

R 14 is selected from the group consisting of

C 1 -C 3 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R 13a ,

C 1 -C 8 -haloalkyl, and

C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy;

R 15 is selected from the group consisting of hydrogen,

C 1 -C 8 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R 13a , and

C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy;

R 16 is selected from the group consisting of hydrogen and C 1 -C 8 -alkyl, or

R 15 and R 16 together with the nitrogen atom, to which they are bound, form a heterocyclic radical, selected from the group consisting of pyrrolidinyl, piperidinyl, piperazinyl, N-alkylpiperazinyl, N-phenylpiperazinyl, and morpholinyl;

R 17 is selected from the group consisting of C 1 -C 8 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals R 17 ,

C 1 -C 8 -haloalkyl,

C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3 or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy,

phenyl, and 5- or 6-membered hetaryl having 1, 2 or 3 heteroatoms as ring members, the heteroatoms being selected from the group consisting of O, S, and N, wherein phenyl and hetaryl are unsubstituted or carry 1, 2, 3, 4, or 5 identical or different radicals R 17b , wherein R 17a is as defined for R 13a and R 17b is as defined for R 13b ; or a pharmaceutically acceptable salt or tautomer thereof.

2. A compound according to claim 1 , wherein X is O, NH or NR X .

3. A compound according to claim 1 , wherein A is CH 2 .

4. A compound according to claim 1 of the formula Ia

wherein

R a and R b are, independently of each other, selected from the group consisting of hydrogen, halogen, C 1 -C 4 alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 alkoxy, and C 1 -C 4 haloalkoxy; R b may also be OH, if R a is hydrogen, C 1 -C 4 alkyl, or C 1 -C 4 haloalkyl; and

X is O, NH, or N—R x , wherein Het, R x , R 1 , R 2 and R 3 are as defined in claim 1 , or a pharmaceutically acceptable salt or tautomer thereof.

5. A compound according to claim 4 , wherein R a and R b are hydrogen.

6. A compound according to claim 1 , wherein Het is a radical of the formulae

wherein R 10a is hydrogen or has one of the meanings given for R 10 , R 11a is hydrogen or has one of the meanings given for R 11 and wherein * denotes the point of attachment to the moiety Y.

7. A compound according to claim 1 , wherein R 1 is located in the 3- or 4-position of the phenyl ring.

8. A compound according to claim 7 , wherein R 4 is selected from the group consisting of

C 3 -C 8 -alkyl, which is unsubstituted or carries one radical selected from the group consisting of OH, C 1 -C 4 -alkoxy, C 3 -C 8 -cycloalkyl, and phenyl, wherein the phenyl ring itself is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals selected from the group consisting of fluorine, chlorine, CN, C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy, difluoromethyl, trifluoromethyl, difluoromethoxy, and trifluoromethoxy,

C 1 -C 8 -haloalkyl,

C 3 -C 8 -cycloalkyl, which is unsubstituted or carries 1, 2, 3, or 4 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy,

phenyl, which is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different radicals selected from the group consisting of fluorine, chlorine, CN, C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy, difluoromethyl, trifluoromethyl, difluoromethoxy, and trifluoromethoxy, and

5- or 6-membered hetaryl having 1, 2 or 3 heteroatoms as ring members, the heteroatoms being selected from the group consisting of O, S, and N, wherein hetaryl is unsubstituted or carries 1, 2, 3, or 4 identical or different radicals selected from the group consisting of fluorine, chlorine, CN, C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy, difluoromethyl, trifluoromethyl, difluoromethoxy, and trifluoromethoxy.

9. A compound according to claim 7 , wherein R 2 is bound to the 3-position of the benzene ring, and

R 4 together with R 2 forms a C 1 -C 5 -alkylene or C 2 -C 5 alkenylene moiety, wherein one CH 2 -moiety may be replaced by oxygen, sulphur or a N—R 4c -moiety, and wherein C 1 -C 5 -alkylene and C 2 -C 5 -alkenylene may be unsubstituted or carry 1, 2, 3, or 4 radicals selected from the group consisting of halogen, CN, OH, NH 2 , C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkylamino, di-(C 1 -C 4 -alkyl)amino, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy.

10. A pharmaceutical composition comprising at least one compound as claimed in claim 1 , together with at least one physiologically acceptable carrier or auxiliary substance.

11. The compound according to claim 1 of the formulae Ia.1.a, Ia.2.a, Ia.3.a, or Ia.4.a

wherein R a and R b are, independently of each other, selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy; R b may also be OH, if R a is hydrogen, C 1 -C 4 -alkyl, or C 1 -C 4 -haloalkyl;

X is O, NH, or N—R x , wherein R x , R 4 , R 2 and R 3 are as defined in claim 1 , R 10a is hydrogen or has one of the meanings given for R 10 , R 11a is hydrogen or has one of the meanings given for R 11 , or a pharmaceutically acceptable salt thereof.

12. The compound according to claim 11 , wherein R a and R b are hydrogen.

13. The compound according to claim 1 , which is of the formulae Ia.1.a′, Ia.2.a′. Ia.3.a′, or Ia.4.a′

wherein -Q- is —C(R Q1 R Q2 )—, —C(R Q1 R Q2 )—C(R Q3 R Q4 )—, or —C(R Q1 )═C(R Q2 )—, wherein R Q1 , R Q2 , R Q3 , R Q4 are each independently of each other selected from the group consisting of hydrogen, halogen, CN, OH, NH 2 , C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkylamino, di-(C 1 -C 4 -alkyl)amino, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy; R a and R b are, independently of each other, selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, and C 1 -C 4 -haloalkoxy; R b may also be OH, if R a is hydrogen, C 1 -C 4 -alkyl, or C 1 -C 4 -haloalkyl;

X is O, NH or N—R x , wherein R x , R 4 and R 3 are as defined in claim 1 , R 10a is hydrogen or has one of the meanings given for R 10 , R 11a is hydrogen or has one of the meanings given for R 11 , or a pharmaceutically acceptable salt thereof.

14. The compound according to claim 13 , wherein R a and R b are hydrogen.

15. The compound according to claim 13 , wherein Q is CH 2 .

16. The compound according to claim 1 , which is selected from the group consisting of

1-{4-[(1-Methyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(5-Methyl-2H-pyrazol-3-ylmethyl)amino]phenyl}butan-1-one;

1-(4-{[4-Bromo-2-(4-chlorobenzyl)-2H-pyrazol-3-ylmethyl]amino}phenyl)butan-1-one;

1-(4-{[3-(Thiophen-2-yl)-1H-pyrazol-4-ylmethyl]amino}phenyl)butan-1-one;

1-(4-{[3-(4-(Trifluoromethylphenyl)-1H-pyrazol-4-ylmethyl]amino}phenyl)butan-1-one;

1-{4-[(2,5-Dimethyl-2H-pyrazol-3-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(5-Methyl-1-phenyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-(4-{[5-(4-Chlorophenoxy)-1,3-dimethyl-1H-pyrazol-4-ylmethyl]amino}phenyl)butan-1-one;

1-(4-{[5-(3-Chlorophenoxy)-1,3-dimethyl-1H-pyrazol-4-ylmethyl]amino}phenyl)butan-1-one;

1-{4-[(5-Chloro-3-methyl-1-phenyl-1-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-(4-{[5-Chloro-1-methyl-3-(phenylthiomethyl)-1H-pyrazol-4-yl]methylamino}phenyl)butan-1-one;

1-(4-{[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methylamino}phenyl)butan-1-one;

1-{4-[(1-Ethyl-5-methyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(2-Phenyl-2H-pyrazol-3-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(1-tert-Butyl-3,5-dimethyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(5-Methyl-2H-pyrazol-3-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(1,5-Dimethyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(1,3-Dimethyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(1-Methyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-(4-{[3-(5-Methylfuran-2-yl)-1-phenyl-1H-pyrazol-4-ylmethyl]amino}phenyl)butan-1-one;

1-(4-{[1-Phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-ylmethyl]amino}phenyl)butan-1-one;

1-{4-[(1-Ethyl-5-methyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(1-Ethyl-3-methyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(1-Ethyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(1H-Pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(2,5-Dimethyl-1H-pyrazol-3-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(3-Methyl-1-propyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(5-Methyl-1-propyl-1H-pyrazol-4-ylmethyl)amino])phenyl}butan-1-one;

1-{4-[(1-Methyl-1H-pyrazol-3-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(1-Methyl-5-phenyl-1H-pyrazol-4-ylmethyl)amino]phenyl}) butan-1-one;

1-{4-[(1,5-Dimethyl-1H-pyrazol-3-ylmethyl)amino]phenyl}butan-1-one;

1-{4-[(1-Isopropyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

1-(4-{[3-(4-Hydroxyphenyl)-1H-pyrazol-4-ylmethyl]amino}phenyl)butan-1-one;

1-{4-[(3-tert-Butyl-1H-pyrazol-4-ylmethyl)amino]phenyl}butan-1-one;

2,2,2-Trifluoroethanesulfonic acid (4-butyryl-phenyl)-[1-(2,2,2-trifluoro-ethanesulfonyl)-3-(4-trifluoromethylphenyl)-1H-pyrazol-4-ylmethyl]-amide;

5-{[3-(4-Trifluoromethylphenyl)-1H-pyrazol-4-ylmethyl]-amino}-indan-1-one;

6-{[3-(4-Trifluoromethylphenyl)-1H-pyrazol-4-ylmethyl]-amino}-3,4-dihydro-2H-naphthalen-1-one;

Ethanesulfonic acid (4-butyryl-phenyl)-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amide;

2,2,2-Trifluoro-ethanesulfonic acid (4-butyryl-phenyl)-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amide;

2,2,2-Trifluoro-ethanesulfonic acid (3-butyryl-phenyl)-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amide;

Ethanesulfonic acid (3-butyryl-phenyl)-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amide;

Ethanesulfonic acid (3-butyryl-phenyl)-(3-thiophen-2-yl-1H-pyrazol-4-ylmethyl)-amide;

2,2,2-Trifluoro-ethanesulfonic acid (3-butyryl-phenyl)-(3-thiophen-2-yl-1H-pyrazol-4-ylmethyl)-amide;

2,2,2-Trifluoro-ethanesulfonic acid (4-butyryl-phenyl)-(3-thiophen-2-yl-1H-pyrazol-4-ylmethyl)-amide;

Ethanesulfonic acid (4-butyryl-phenyl)-(3-thiophen-2-yl-1H-pyrazol-4-ylmethyl)-amide;

Ethanesulfonic acid (3-tert-butyl-1H-pyrazol-4-ylmethyl)-(4-butyryl-phenyl)-amide;

2,2,2-Trifluoro-ethanesulfonic acid (3-tert-butyl-1H-pyrazol-4-ylmethyl)-(4-butyryl-phenyl)-amide;

2,2,2-Trifluoro-ethanesulfonic acid (3-tert-butyl-1H-pyrazol-4-ylmethyl)-(3-butyryl-phenyl)-amide;

Ethanesulfonic acid (3-tert-butyl-1H-pyrazol-4-ylmethyl)-(3-butyryl-phenyl)-amide;

1-(4-{[3-(4-Methoxy-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-{4-[(3-Phenyl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(1,3,5-Trimethyl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(3-p-Tolyl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-(4-{[3-(3,5-Difluoro-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-{4-[(1-Phenyl-3-pyridin-4-yl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(2-Methyl-2H-pyrazol-3-ylmethyl)-amino]-phenyl}-butan-1-one;

1-(4-{[3-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(4-{[3-(3,4-Dimethoxy-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-{4-[(1-Benzyl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-(4-{[3-(4-Fluoro-phenyl)-1-phenyl-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-1-one;

1-{4-[(1-Phenyl-3-pyridin-3-yl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(3,5-Dimethyl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-(4-{[1-Methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(4-{[1-Methyl-5-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(4-{[3-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(3-{Methyl-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

2,2,2-Trifluoro-ethanesulfonic acid (5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amide;

2-Methyl-7-{[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-chromen-4-one;

1-(4-{Methyl-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

2,2,2-Trifluoro-ethanesulfonic acid (4-butyryl-phenyl)-[1-methyl-5-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amide;

2,2,2-Trifluoro-ethanesulfonic acid (4-butyryl-phenyl)-[1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amide;

2,2,2-Trifluoro-ethanesulfonic acid (4-butyryl-phenyl)-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amide;

1-(4-{[3-(3-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

7-{[3-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-3,4-dihydro-2H-naphthalen-1-one;

6-{[3-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-indan-1-one;

1-(2-Methoxy-4-{[3-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(2-Hydroxy-4-{[3-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-[4-{[3-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-2-(1-ethyl-propoxy)-phenyl]-butan-1-one;

1-{4-[(3-Methyl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(3-Propyl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(3-Isopropyl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(3-Ethyl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[3-(4-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-phenyl}-pentan-1-one;

1-{4-[3-(4-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-phenyl}-hexan-1-one;

1-{4-[3-(4-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethylsulfanyl]-phenyl}-butan-1-one;

1-{4-[3-(4-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethanesulfonyl]-phenyl}-butan-1-one;

1-{4-[3-(4-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-phenyl}-butan-1-one;

1-{4-[3-(4-Fluoro-phenyl)-1H-pyrazol-4-ylmethoxy]-phenyl}-butan-1-one;

1-{4-[3-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethoxy]-phenyl}-butan-1-one;

1-{4-[3-(3-Fluoro-phenyl)-1H-pyrazol-4-ylmethoxy]-phenyl}-butan-1-one;

1-{4-[3-(3-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-phenyl}-butan-1-one;

1-[4-(3-Phenyl-1H-pyrazol-4-ylmethoxy)-phenyl]-butan-1-one, trifluoroacetic acid;

1-{4-[1-(3-Phenyl-1H-pyrazol-4-yl)-ethoxy]-phenyl}-butan-1-one;

1-(4-{[3-(4-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-ethanone;

1-(3-Nitro-4-{[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-ethanone;

1-(3-{[3-(4-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(4-{[3-(4-Fluoro-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(4-{[3-(3-Chloro-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(4-{[3-(2-Chloro-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(4-{[3-(3-Fluoro-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-phenyl)-butan-1-one;

1-{4-[(3-Pyridin-3-yl-1H-pyrazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-(4-{[4-(4-Methoxy-phenyl)-1H-pyrazol-3-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(3-{[4-(4-Methoxy-phenyl)-1H-pyrazol-3-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(3-{[4-(4-Ethyl-phenyl)-1H-pyrazol-3-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(4-{[4-(4-Ethyl-phenyl)-1H-pyrazol-3-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(4-{[4-(4-Trifluoromethyl-phenyl)-1H-pyrazol-3-ylmethyl]-amino}-phenyl)-butan-1-one;

1-(4-{[4-(4-Chloro-phenyl)-1H-pyrazol-3-ylmethyl]-amino}-phenyl)-butan-1-one;

1-{4-[4-(4-Methoxy-phenyl)-1H-pyrazol-3-ylmethoxy]-phenyl}-butan-1-one;

1-{4-[4-(4-Ethyl-phenyl)-1H-pyrazol-3-ylmethoxy]-phenyl}-butan-1-one;

1-[4-(4-Bromo-1H-pyrazol-3-ylmethoxy)-phenyl]-butan-1-one;

1-{4-[(4-Phenyl-1H-pyrrol-3-ylmethyl)-amino]-phenyl}-butan-1-one;

2-Propyl-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Propyl-5-[3-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

5-[3-(4-Fluoro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-propyl-2,3-dihydro-isoindol-1-one;

5-[3-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-propyl-2,3-dihydro-isoindol-1-one;

5-[3-(3-Chloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-propyl-2,3-dihydro-isoindol-1-one;

5-[3-(3-Fluoro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-propyl-2,3-dihydro-isoindol-1-one;

5-(3-Phenyl-1H-pyrazol-4-ylmethoxy)-2-propyl-2,3-dihydro-isoindol-1-one;

5-[3-(3-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2-(3,3,3-trifluoro-propyl)-2,3-dihydro-isoindol-1-one;

5-[3-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-(3,3,3-trifluoro-propyl)-2,3-dihydro-isoindol-1-one;

5-[3-(4-Fluoro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-(3,3,3-trifluoro-propyl)-2,3-dihydro-isoindol-1-one;

5-[3-(3-Fluoro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-(3,3,3-trifluoro-propyl)-2,3-dihydro-isoindol-1-one;

5-[3-(4-Trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2-(3,3,3-trifluoro-propyl)-2,3-dihydro-isoindol-1-one;

5(3-Phenyl-1H-pyrazol-4-ylmethoxy)-243,3,3-trifluoro-propyl)-2,3-dihydro-isoindol-1-one;

2-Butyl-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Butyl-5-[3-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Butyl-5-[3-(4-chloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Butyl-5-[3-(3,4-dichloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Butyl-5-[3-(4-fluoro-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Butyl-5-[3-(3-chloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Butyl-5-[3-(3-fluoro-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Butyl-5-(3-phenyl-1H-pyrazol-4-ylmethoxy)-2,3-dihydro-isoindol-1-one, trifluoroacetic acid;

2-(4,4,4-Trifluoro-butyl)-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

5-(3-Phenyl-1H-pyrazol-4-ylmethoxy)-2-(4,4,4-trifluoro-butyl)-2,3-dihydro-isoindol-1-one;

5-[3-(3,4-dichloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-(4,4,4-trifluoro-butyl)-2,3-dihydro-isoindol-1-one;

2-(3-Methyl-butyl)-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-(3-Methyl-butyl)-5-(3-phenyl-1H-pyrazol-4-ylmethoxy)-2,3-dihydro-isoindol-1-one;

5-(3-Phenyl-1H-pyrazol-4-ylmethoxy)-2-(2-trifluoromethoxy-ethyl)-2,3-dihydro-isoindol-1-one;

2-Ethyl-5-[3-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Ethyl-5-[3-(4-fluoro-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Ethyl-5-[3-(3-fluoro-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

5-[3-(3-Chloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-ethyl-2,3-dihydro-isoindol-1-one;

5-[3-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-ethyl-2,3-dihydro-isoindol-1-one;

2-Ethyl-5-(3-phenyl-1H-pyrazol-4-ylmethoxy)-2,3-dihydro-isoindol-1-one;

2-(2-Bromo-ethyl)-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-(2-Bromo-ethyl)-5-[3-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-(2,2-Difluoro-ethyl)-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-(2,2-Difluoroethyl)-5-(3-phenyl-1H-pyrazol-4-ylmethoxy)-2,3-dihydro-isoindol-1-one;

2-(2,2,2-Trifluoroethyl)-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-(2,2,2-Trifluoroethyl)-5-[3-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

5-[3-(4-Fluorophenyl)-1H-pyrazol-4-ylmethoxy]-2-(2,2,2-trifluoro-ethyl)-2,3-dihydro-isoindol-1-one;

5-[3-(3-Fluorophenyl)-1H-pyrazol-4-ylmethoxy]-2-(2,2,2-trifluoro-ethyl)-2,3-dihydro-isoindol-1-one;

5-[3-(4-Trifluoromethylphenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Methyl-5-[3-(4-trifluoromethylphenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Propyl-6-[3-(4-trifluoromethylphenyl)-1H-pyrazol-4-ylmethoxy]-3,4-dihydro-2H-isoquinolin-1-one;

2-Propyl-5-{[3-(4-trifluoromethylphenyl)-1H-pyrazol-4-ylmethyl]-amino}-2,3-dihydro-isoindol-1-one;

5-{[3-(4-Chlorophenyl)-1H-pyrazol-4-ylmethyl]-amino}-2-propyl-2,3-dihydro-isoindol-1-one;

5-{[3-(3-Chlorophenyl)-1H-pyrazol-4-ylmethyl]-amino}-2-propyl-2,3-dihydro-isoindol-1-one;

2-Propyl-5-{[3-3-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-2,3-dihydro-isoindol-1-one;

5-{[3-(4-Fluorophenyl)-1H-pyrazol-4-ylmethyl]-amino}-2-propyl-2,3-dihydro-isoindol-1-one;

5-{[3-(3-Fluorophenyl)-1H-pyrazol-4-ylmethyl]-amino}-2-propyl-2,3-dihydro-isoindol-1-one;

5-[(3-Phenyl-1H-pyrazol-4-ylmethyl)-amino]-2-propyl-2,3-dihydro-isoindol-1-one;

2-Propyl-5-{[4-3-trifluoromethyl-phenyl)-1H-pyrazol-3-ylmethyl]-amino}-2,3-dihydro-isoindol-1-one;

2-Propyl-5-{[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-isoindole-1,3-dione;

2-Propyl-6 {[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-amino}-2,3-dihydro-isoquinolin-1-one;

2-(4-Trifluoromethoxy-benzyl)-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Cyclohexylmethyl-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Isobutyl-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Cyclopentyl-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one; and

2-Phenyl-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

or a pharmaceutically acceptable salt thereof.

17. The compound according to formula Ia.1.a′ of claim 13 , which is selected from the group consisting of

2-Propyl-5-[3-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Butyl-5-[3-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one;

2-Butyl-5-[3-(4-fluorophenyl)-1H-pyrazol-4-ylmethoxy]-2,3-dihydro-isoindol-1-one, trifluoroacetic acid; and

2-Butyl-5-(3-phenyl-1H-pyrazol-4-ylmethoxy)-2,3-dihydro-isoindol-1-one, trifluoroacetic acid;

or a pharmaceutically acceptable salt thereof.

18. A compound, which is selected from the group consisting of

3-[(3-tert-Butyl-1H-pyrazol-4-ylmethyl)-amino]-phenol;

1-{4-[(5-Phenyl)-2H-[1,2,3]triazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(3-Phenyl-pyridin-4-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(4-Phenyl-pyridin-3-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(2-Phenyl-pyridin-3-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(6-Phenyl-pyridin-3-ylmethyl)-amino]-phenyl}-butan-1-one;

1-(4-{[6-(4-Fluoro-phenyl)-pyridin-2-ylmethyl]-amino}-phenyl)-butan-1-one;

1-{4-[(Pyrazolo[1,5-a]pyridin-3-ylmethyl)-amino]-phenyl}-butan-1-one;

1-{4-[(3-Methyl-5-phenyl-isoxazol-4-ylmethyl)-amino]-phenyl}-butan-1-one;

5-[(3-Methyl-5-phenyl-isoxazol-4-ylmethyl)-amino]-2-propyl-2,3-dihydro-isoindol-1-one; and

1-[3-(Benzyl-pyridin-3-ylmethylamino)-phenyl]-butan-1-one;

or a pharmaceutically acceptable salt thereof.