Therapeutic methods and devices following myocardial infarction
View Patent ↗Described herein are methods of treating a patient to prevent or correct cardiac remodeling following myocardial infarction. In general these methods may include inserting or implanting a device in a heart chamber to support the affected region within 72 hours after myocardial infarction. The device may be a support device (e.g., a resilient frame) and/or a partitioning device.
1. A method of preventing or reducing cardiac remodeling following myocardial infarction comprising:
delivering percutaneously a device to a heart chamber exhibiting myocardial infarction, wherein the device comprises a reinforced, non-inflatable membrane, and a flexible support frame; and
deploying the device in the chamber adjacent a region of the chamber wall exhibiting myocardial infarction such that at least a portion of the device is in contact with and covers a surface of the chamber wall.
2. The method of claim 1 , further comprising identifying the region of the heart chamber exhibiting myocardial infarction.
3. The method of claim 1 , wherein the step of delivering the device comprises delivering the device in a collapsed configuration.
4. The method of claim 1 , wherein the flexible support frame is an expandable frame.
5. The method of claim 1 , wherein the device comprises a foot region configured to contact the wall of the heart chamber.
6. The method of claim 1 , wherein the step of delivering the device comprises delivering the device using a delivery catheter.
7. The method of claim 1 , wherein the step of delivering the device comprises delivering the device into a left ventricle exhibiting myocardial infarction.
8. The method of claim 1 , wherein the step of deploying the device comprises expanding the device from a collapsed configuration into a deployed configuration.
9. The method of claim 1 , wherein the step of deploying the device comprises forming a seal about a periphery of the membrane against the chamber wall.
10. The method of claim 1 wherein the step of deploying the device comprises isolating the region of the chamber wall exhibiting myocardial infarction from regions of the chamber wall not exhibiting myocardial infarction.
11. The method of claim 1 , wherein the step of deploying the device comprises anchoring the device to the wall of the chamber without damaging the pericardium.
12. The method of claim 1 , wherein the step of deploying the device comprises partitioning the heart chamber into a main productive portion and a secondary non-productive portion, with the region of the chamber exhibiting myocardial infarction forming a part of the secondary non-productive portion.
13. The method of claim 1 , further comprising delivering a therapeutic agent from the device.
14. The method of claim 13 , wherein the step of delivering a therapeutic agent from the device comprises delivering a therapeutic agent impregnated or coated on the device.
15. The method of claim 1 , wherein the reinforced, non-inflatable membrane comprises a first surface defined by a peripheral edge and a second surface also defined by the peripheral edge, wherein the second surface opposes the first surface; and wherein the device is deployed in the left ventricle adjacent a region of the left ventricle exhibiting myocardial infarction such that the first surface faces away from the region of the left ventricle exhibiting myocardial infarction while the second surface faces towards the region of the left ventricle exhibiting myocardial infarction.
16. The method of claim 1 , wherein the reinforced, non-inflatable membrane comprises a plurality of struts.
17. The method of claim 1 , wherein the device is delivered percutaneously through a blood vessel and a heart valve.
18. A method of preventing or reducing cardiac remodeling following myocardial infarction comprising:
delivering percutaneously a partitioning device to a left ventricle, wherein the device comprises a reinforced membrane having a first surface defined by a peripheral edge and a second surface also defined by the peripheral edge, wherein the second surface opposes the first surface, wherein the reinforced membrane includes a flexible support frame; and
deploying the device in the left ventricle adjacent a region of the left ventricle exhibiting myocardial infarction such that the first surface faces away from the region of the left ventricle exhibiting myocardial infarction while the second surface faces towards the region of the left ventricle exhibiting myocardial infarction.
19. A method of preventing or reducing cardiac remodeling following myocardial infarction comprising:
delivering a support device having a reinforced membrane to a heart chamber exhibiting myocardial infarction, wherein the support device comprises an expandable frame having a plurality of struts; and
deploying the support device in the chamber adjacent a region of the chamber wall exhibiting myocardial infarction such that at least a portion of the support device is in contact with and covers a surface of the chamber wall.
20. The method of claim 19 , further comprising identifying a region of the heart chamber exhibiting myocardial infarction.
21. The method of claim 19 , wherein the step of delivering the support device comprises delivering the support device in a collapsed configuration.
22. The method of claim 19 , wherein the step of delivering the support device comprises delivering a support device having a plurality of struts extending from a central hub.
23. The method of claim 19 , wherein the step of deploying the support device comprises securing the support device to the wall of the chamber, wherein the support device may dynamically flex as the wall of the chamber moves.