OPHTHALMIC COMPOSITION WITH HYALURONIC ACID
An ophthalmic composition comprising a polymeric biguanide composition having less than 18 mol % of terminal amine groups and 55 mol % or greater of terminal guanidine groups as measured by 13 C NMR, and 0.005 w/v % to 0.04 w/v % hyaluronic acid. Alternatively, the ophthalmic composition comprises a polymeric biguanide composition comprising less than 18 mol % of terminal amine groups and 40 mol % or greater of terminal cyanoguanidino groups as measured by 13 C NMR, and 0.005 w/v % to 0.04 w/v % hyaluronic acid. The compositions can be used for cleaning, disinfecting or packaging a contact lens.
1 . An ophthalmic composition comprising:
a polymeric biguanide composition comprising less than 18 mol % of terminal amine groups, and 55 mol % or greater of terminal guanidine groups as measured by 13 C NMR; and 0.005 w/v % to 0.04 w/v % hyaluronic acid.
2 . The composition of claim 1 wherein the polymeric biguanide composition comprises less than 15 mol % of terminal amine groups, and 60 mol % or greater of terminal guanidine groups.
3 . The composition of claim 2 wherein the polymeric biguanide composition comprises less than 10 mol % of terminal amine groups and 65 mol % or greater of terminal guanidine groups.
4 . The composition of claim 1 wherein the weight ratio of hyaluronic acid to the polymeric biguanide composition in the composition is from 55:1 to 90:1.
5 . The composition of claim 1 further comprising 0.01 wt. % to 0.8 wt. % of an amphoteric surfactant of general formula I
wherein R 1 is R or —(CH 2 ) n —NHC(O)R, wherein R is a C 8 -C 30 alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R 2 and R 3 are each independently selected from the group consisting of hydrogen and C 1 -C 4 alkyl; R 4 is a C 2 -C 8 alkylene optionally substituted with hydroxyl; and Y is CO 2 − or SO 3 − .
6 . The composition of claim 1 further comprising 1 ppm to 3 ppm polyquaternium-1.
7 . The composition of claim 1 wherein the hyaluronic acid is obtained via a fermentation mixture comprising Streptococcus equi.
8 . The composition of claim 4 wherein the hyaluronic acid is present from 0.01 wt. % to 0.025 wt. %.
9 . The use of the composition of claim 1 to clean, disinfect or package contact lenses, as a preservative in a pharmaceutical composition that includes a pharmaceutical agent, or as a preservative in a health care product.
10 . An ophthalmic composition comprising:
a polymeric biguanide composition comprising less than 18 mol % of terminal amine groups and 40 mol % or greater of terminal cyanoguanidino groups as measured by 13 C NMR; and
0.005 w/v % to 0.04 w/v % hyaluronic acid, wherein the weight ratio of hyaluronic acid to the polymeric biguanide composition in the composition is from 55:1 to 90:1; and
an amphoteric surfactant of general formula I
wherein R 1 is R or —(CH 2 ) n —NHC(O)R, wherein R is a C 8 -C 30 alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R 2 and R 3 are each independently selected from the group consisting of hydrogen and C 1 -C 4 alkyl; R 4 is a C 2 -C 8 alkylene optionally substituted with hydroxyl; and Y is CO 2 − or SO 3 − .
11 . The composition of claim 10 wherein the polymeric biguanide composition comprises less than 15 mol % of terminal amine groups and 50 mol % or greater of terminal cyanoguanidino groups.
12 . The composition of claim 10 wherein the polymeric biguanide composition comprises from 10 mol % to 30 mol % of terminal guanidine groups.
13 . The composition of claim 10 wherein the hyaluronic acid is obtained via a fermentation mixture comprising Streptococcus equi.
14 . The composition of claim 10 wherein the hyaluronic acid is present from 0.01 wt. % to 0.025 wt. %.
15 . The use of the composition of claim 10 to clean, disinfect or package contact lenses, as a preservative in a pharmaceutical composition that includes a pharmaceutical agent, or as a preservative in a health care product.
16 . A method of cleaning, disinfecting or packaging a contact lens comprising contacting said contact lens with the ophthalmic composition of claim 1 .
17 . A method of cleaning, disinfecting or packaging a contact lens comprising contacting said contact lens with the ophthalmic composition of claim 10 .