Sample holder and sample preparation device
View Patent ↗An apparatus for forming a solid sample from a sample solution and then analyzing the solid sample to determine the solid form of the sample is provided. The apparatus may optionally comprise a masking block with an array of openings, a film on which the solid sample can be deposited, and a sheet. The apparatus may optionally comprise a masking block with an array of openings and a sheet on which the sample can be deposited. The apparatus may comprise the formation unit of a system for forming a solid sample and analyzing the solid sample. The system may further comprise an analysis unit comprising the film and/or sheet with the solid samples and a spacer unit attached to the film after it has been removed from the formation unit. Methods for using the apparatus and/or system of the present invention are also provided.
1. An apparatus for the formation of solids and analysis of solid forms comprising:
a masking block with an array of openings;
a sheet;
a film, wherein the film is located between the masking block and the sheet and wherein the film forms a liquid tight seal with the masking block; and
a bottom support plate, wherein the sheet is located between the film and the bottom support plate.
2. The apparatus of claim 1 , further comprising a non-stick film, wherein the non-stick film is located between the film and the sheet.
3. The apparatus of claim 1 , wherein the liquid tight seal is a pressure seal.
4. The apparatus of claim 1 , wherein the film comprises polypropylene, mylar, kapton or Prolene.
5. The apparatus of claim 1 , wherein the film is visually clear.
6. A system for the formation of solids and analysis of solid forms comprising:
a formation unit, wherein the formation unit comprises:
a masking block with an array of openings,
a sheet, and
a film on which an array of solids is deposited,
wherein the film is located between the masking block and the sheet and separable from the masking block and sheet, and
wherein the film forms a liquid tight seal with the masking block; and
an analysis unit, wherein the analysis unit comprises:
the film with the array of solids, wherein the film is separated from the masking block and the sheet,
a spacer plate, wherein the spacer plate has approximately the same array of holes as the masking block, and
wherein the film is attached to the spacer plate.
7. The system of claim 6 , wherein the film is attached to the spacer plate by adhesive.
8. The system of claim 6 , wherein the analysis unit further comprises a cover, and wherein the cover is on an opposite side of the spacer plate than the film.
9. The system of claim 6 , wherein the formation unit further comprises a bottom support plate, and wherein the sheet is located between the film and the bottom support plate.
10. The system of claim 6 , wherein the formation unit further comprises a non-stick film, and wherein the non-stick film is located between the film and the sheet.
11. The system of claim 6 , wherein the liquid tight seal is a pressure seal.
12. A method of forming a solid and analyzing the solid form of the solid comprising the steps of:
placing at least one aliquot of a liquid containing one or more solvents and at least one organic or inorganic chemical compound in an opening of a formation unit to form a sample, wherein the formation unit comprises a masking block comprising an array of openings, a film, and a sheet, wherein the film is located between the masking block and the sheet, and wherein the film forms a liquid tight seal with the masking block;
removing liquid from the sample to deposit a solid;
removing the film from the masking block and the sheet;
attaching the film to a spacer plate, wherein the spacer plate has approximately the same array of holes as the masking block, and wherein the film is attached to the spacer plate before analyzing the solid to determine the solid form; and
analyzing the solid to determine the solid form of the solid.
13. The method of claim 12 , wherein the solid form is crystalline.
14. The method of claim 12 , wherein the solid form is x-ray amorphous.
15. The method of claim 12 , wherein the sample is a solution.
16. The method of claim 12 , wherein the solid form is a cocrystal.
17. The method of claim 12 , wherein the film is separated from the masking block and the sheet before analysis.
18. The method of claim 12 , wherein the solid form is analyzed by x-ray powder diffraction in transmission mode, x-ray powder diffraction in reflection mode, light microscopy, Raman spectroscopy, Raman microscopy, infrared spectroscopy, near-infrared spectroscopy, or a combination thereof.
19. The method of claim 12 , further comprising the step of placing a cover on the spacer plate, the cover being on the opposite side of the spacer plate from the film.
20. A system for the formation of solids and analysis of solid forms comprising:
a formation unit, wherein the formation unit comprises:
a masking block with an array of openings, and
a sheet on which an array of solids is deposited,
wherein the sheet is separable from the masking block, and wherein the sheet forms a liquid tight seal with the masking block; and
an analysis unit, wherein the analysis unit comprises:
the sheet with the array of solids, wherein the sheet is separated from the masking block,
a spacer plate, wherein the spacer plate has approximately the same array of holes as the masking block,
and wherein the sheet is attached to the spacer plate.
21. The system of claim 20 , wherein the sheet is attached to the spacer plate by adhesive.
22. The system of claim 20 , wherein the analysis unit further comprises a cover, and wherein the cover is on an opposite side of the spacer plate than the sheet.
23. The system of claim 20 , wherein the formation unit further comprises a bottom support plate, and wherein the sheet is located between the masking block and the bottom support plate.
24. A method of forming a solid and analyzing the solid to determine the solid form comprising the steps of:
placing at least one aliquot of a liquid containing one or more solvents and at least one organic or inorganic chemical compound in an opening of a formation unit to form a sample, wherein the formation unit comprises a masking block comprising an array of openings and a sheet, wherein the sheet forms a liquid tight seal with the masking block;
removing liquid from the sample to deposit a solid;
removing the sheet from the masking block;
attaching the sheet to a spacer plate, wherein the spacer plate has approximately the same array of holes as the masking block; and
analyzing the solid to determine the solid form.
25. The method of claim 24 , further comprising the step of placing a cover on the spacer plate, the cover being on the opposite side of the spacer plate from the sheet.