IP Library Granted Patent US 9,364,287
Granted Patent B2
US 9,364,287 · App. 12/134,009 · Granted Jun 14, 2016

Method for reducing pain of dermatological treatments

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Quick Facts
Patent No.
US 9,364,287
App. No.
12/134,009
Granted
Jun 14, 2016
Kind
B2
Abstract

A method of reducing the level of pain experienced by a patient during a pain-inducing dermatological treatment by using non-pharmacologic means is described. The method employs the use of multiple bursts of a gas to stimulate a touch sensation in or near the tissue to be treated using the dermatological treatment in order to reduce and/or relieve pain. The method can be used alone or can be used in combination with other non-pharmacologic and/or pharmacologic methods of relieving pain in order to make a patient more comfortable during or following the dermatological treatment.

Claims (33)

1. A method of reducing the level of pain experienced by a patient during a pain-inducing dermatological treatment, comprising:

stimulating a touch sensation in a patient in an area in or near a region of tissue to be treated during a pain-inducing dermatological treatment,

wherein the stimulating of the touch sensation is achieved by directing multiple bursts of a gas at or near the region of tissue so as to reduce the level of pain experienced by the patient during the pain-inducing dermatological treatment.

2. The method of claim 1 , further comprising:

providing the pain-inducing dermatological treatment to a patient.

3. A method of reducing the dosage of anesthetic required by a patient undergoing a pain-inducing dermatological treatment, comprising:

stimulating a touch sensation in a patient in an area in or near a region of tissue to be treated during a pain-inducing dermatological treatment,

wherein the stimulating of the touch sensation is achieved by directing multiple bursts of a gas at or near the region of tissue, and

wherein the stimulating of the touch sensation reduces the dosage of anesthetic required to reduce the level of pain experienced by a patient undergoing the pain-inducing dermatological treatment.

4. The method of claim 3 , wherein the method comprises stimulating a touch sensation in the region of tissue to be treated by the pain-inducing dermatological treatment.

5. The method of claim 3 , wherein the method comprises stimulating a touch sensation in a region of tissue immediately adjacent to the region of tissue to be treated by the pain-inducing dermatological treatment.

6. The method of claim 3 , wherein the method comprises stimulating a touch sensation in a region of tissue which is larger than and encompasses the region of tissue to be treated by the pain-inducing dermatological treatment.

7. The method of claim 3 , wherein the region of tissue to be treated comprises human skin.

8. The method of claim 3 , wherein the multiple bursts of gas are delivered at a rate between about 5 bursts per second and about 100 bursts per second.

9. The method of claim 3 , wherein the multiple bursts of gas are delivered at a rate between about 5 bursts per second and about 50 bursts per second.

10. The method of claim 3 , wherein the multiple bursts of gas are delivered at a rate between about 10 bursts per second and about 30 bursts per second.

11. The method of claim 3 , wherein the multiple bursts of gas comprise bursts of pressurized gas.

12. The method of claim 3 , wherein the gas comprises air.

13. The method of claim 1 or 3 , wherein the gas comprises nitrogen.

14. The method of claim 3 , wherein the temperature of the gas is approximately ambient temperature as it contacts the tissue.

15. The method of claim 3 , wherein the temperature of the gas is between about 20° C. and about 30° C. as it contacts the tissue.

16. The method of claim 3 , wherein the temperature of the gas is below about 20° C. as it contacts the tissue.

17. The method of claim 3 , wherein the temperature of the gas is above about 30° C. as it contacts the tissue.

18. The method of claim 3 , wherein the pain-inducing dermatological treatment comprises an optical energy based treatment.

19. The method of claim 3 , wherein the pain-inducing dermatological treatment comprises a laser treatment.

20. The method of claim 3 , wherein the average pain score experienced by a patient undergoing the pain-inducing dermatological treatment in conjunction with the stimulating is at least 1 point less on a 10 point pain scale than the average pain score experienced by a patient undergoing the pain-inducing dermatological treatment in the absence of the stimulating, where a score of zero is no pain and a score of 10 is the worst pain imaginable.

21. The method of claim 20 , wherein the topical anesthetic is selected from the group consisting of lidocaine, prilocaine, tetracaine, benzocaine, dibucaine, oxybuprocaine, pramoxine, proparacaine, proxymetacaine, and combinations thereof.

22. The method of claim 3 , wherein the average pain score experienced by a patient undergoing the pain-inducing dermatological treatment in conjunction with the stimulating is at least 2 points less on a 10 point pain scale than the average pain score experienced by a patient undergoing the pain-inducing dermatological treatment in the absence of the stimulating, where a score of zero is no pain and a score of 10 is the worst pain imaginable.

23. The method of claim 3 , wherein the anesthetic comprises a topical anesthetic.

24. The method of claim 3 , wherein the dosage of anesthetic required to reduce the level of pain experienced by a patient undergoing the pain-inducing dermatological treatment in conjunction with the stimulating is at least 20% less than the dosage of anesthetic required to reduce the level of pain experienced by a patient undergoing the pain-inducing dermatological treatment in the absence of the stimulating.

25. The method of claim 24 , wherein a dosage of anesthetic required to reduce the level of pain experienced by a patient undergoing the pain-inducing dermatological treatment in the absence of the stimulating comprises the dosage of anesthetic required to prevent the patient from experiencing pain in excess of a pain score of 8 on a 10 point pain scale, where a score of zero is no pain and a score of 10 is the worst pain imaginable.

26. The method of claim 3 , further comprising:

providing the pain-inducing dermatological treatment to a patient.

Assignments (19)
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
Reel/Frame 073654/0242 →
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH, CANADA INC.; BAUSCH HEALTH IRELAND LIMITED; SOLTA MEDICAL IRELAND LIMITED
Reel/Frame 073654/0300 →
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH HEALTH AMERICAS, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.
Reel/Frame 073637/0126 →
U.S. PATENT SECURITY AGREEMENT Recorded Jun 13, 2025
From: MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; BAUSCH HEALTH US, LLC (F/K/A VALEANT PHARMACEUTICALS NORTH AMERICA LLC); PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; BAUSCH HEALTH AMERICAS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON
Reel/Frame 071564/0463 →
U.S. PATENT SECURITY AGREEMENT Recorded Jun 13, 2025
From: MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; BAUSCH HEALTH US, LLC (F/K/A VALEANT PHARMACEUTICALS NORTH AMERICA LLC); PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; BAUSCH HEALTH AMERICAS, INC.; SOLTA MEDICAL, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 071566/0200 →
SECURITY AGREEMENT (SECOND LIEN) Recorded Oct 5, 2022
From: BAUSCH HEALTH US, LLC; BAUSCH HEALTH AMERICAS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 061606/0468 →
SECURITY AGREEMENT (FIRST LIEN) Recorded Oct 4, 2022
From: BAUSCH HEALTH US, LLC; BAUSCH HEALTH AMERICAS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 061595/0066 →
SECURITY INTEREST Recorded Jun 13, 2022
From: BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH, CANADA INC.; BAUSCH HEALTH IRELAND LIMITED; SOLTA MEDICAL IRELAND LIMITED
To: THE BANK OF NEW YORK MELLON
Reel/Frame 060346/0705 →
SECURITY AGREEMENT Recorded Feb 10, 2022
From: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
To: THE BANK OF NEW YORK MELLON
Reel/Frame 059121/0001 →
SECURITY INTEREST Recorded Jun 8, 2021
From: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 056811/0814 →
MERGER Recorded May 14, 2021
From: RELIANT TECHNOLOGIES, LLC
To: SOLTA MEDICAL, INC.
Reel/Frame 056244/0936 →
MERGER Recorded May 12, 2021
From: RELIANT TECHNOLOGIES, INC.
To: RELIANT TECHNOLOGIES, LLC
Reel/Frame 056218/0067 →
SECURITY INTEREST Recorded Mar 11, 2019
From: BAUSCH HEALTH AMERICAS, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 048556/0758 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Jan 27, 2014
From: SILICON VALLEY BANK
To: RELIANT TECHNOLOGIES, LLC
Reel/Frame 032125/0810 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Jan 24, 2014
From: CAPITAL ROYALTY PARTNERS II L.P.; CAPITAL ROYALTY PARTNERS II - PARALLEL FUND "A" L.P.; PARALLEL INVESTMENT OPPORTUNITIES PARTNERS II L.P.
To: RELIANT TECHNOLOGIES, LLC
Reel/Frame 032126/0708 →
SHORT-FORM PATENT SECURITY AGREEMENT Recorded Nov 19, 2013
From: RELIANT TECHNOLOGIES, LLC
To: CAPITAL ROYALTY PARTNERS II L.P.; CAPITAL ROYALTY PARTNERS II - PARALLEL FUND "A" L.P.; PARALLEL INVESTMENT OPPORTUNITIES PARTNERS II L.P.
Reel/Frame 031674/0527 →
SECURITY INTEREST - MEZZANINE LOAN Recorded Apr 18, 2013
From: RELIANT TECHNOLOGIES, LLC
To: SILICON VALLEY BANK
Reel/Frame 030248/0256 →
SECURITY AGREEMENT Recorded Jun 16, 2009
From: RELIANT TECHNOLOGIES, LLC
To: SILICON VALLEY BANK
Reel/Frame 022824/0847 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 22, 2008
From: DEBENEDICTIS, LEONARD C.; DALLAROSA, JOSEPH L.
To: RELIANT TECHNOLOGIES, INC,
Reel/Frame 021320/0680 →