Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators 842
View Patent ↗Compounds of Formula I: wherein R 1 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
1. A compound that is: 7-methyl-5-(3-piperazin-1-ylmethyl-[1,2,4]oxadiazol-5-yl)-2-(4-trifluoromethoxybenzyl)-2,3-dihydroisoindol-1-one having the following structure;
or a pharmaceutically acceptable salt thereof, a hydrate thereof, or a combination of said compound, salt or hydrate.
2. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt or a hydrate or a combination according to claim 1 and a pharmaceutically acceptable carrier or excipient.
3. A method for the treatment schizophrenia, anxiety, or generalized anxiety disorder in an animal in need of such treatment, comprising the step of administering to said animal a therapeutically effective amount of a compound or a pharmaceutically acceptable salt or a hydrate or a combination according to claim 1 .
4. A method for the treatment schizophrenia, anxiety, or generalized anxiety disorder in an animal in need of such treatment, comprising the step of administering to said animal a therapeutically effective amount of a pharmaceutical composition according to claim 2 .