Process and device for monitoring a patient during anesthesia and for determining the combined effect of a plurality of anesthetics
View Patent ↗A process is provided for monitoring a patient being anesthetized, as well as a process for determining a combined effect of different anesthetics used. Devices for carrying out the processes are also provided.
1. An anesthetic process comprising the steps of:
providing an anesthetic administrating device capable of administrating a plurality of anesthetics to a patient;
operating said anesthetic administrating device thereby administrating a plurality of active anesthetic ingredients to the patient;
providing an information management system receiving data from said anesthetic administrating device;
providing a plurality of models connected to said information management system, said models:
determining a concentration of each of the active anesthetic ingredients at a site of action;
determining a potency of each of the active anesthetic ingredients from the determined concentrations of each active anesthetic ingredient at the site of action;
determining an interaction relationship between each of the active anesthetic ingredients;
combining the potencies according the interaction relationship to obtain a combined potency of all the plurality of active anesthetic ingredients;
converting said combined potency to a Noxious Stimulus Response Index (NSRI), said NSRI being a one-dimensional parameter having a full scale range with a first endpoint of said range indicating an alert and non-anesthetized patient, and with a second endpoint of said range indicating a deepest anesthesia, said NSRI being calculated by
NSRI
=
100
*
(
1
-
(
N
/
N
′
)
sl
1
+
(
N
/
N
′
)
sl
)
where:
N is the combined potency;
N′ is a specific value at which an NSRI of 50% is reached; and
sl is a slope factor for the transformation of N into NSRI;
providing a display connected to said models;
displaying the NSRI on said display.
2. An anesthetic process in accordance with claim 1 , wherein:
the interaction relationship is calculated using a mathematical formula based on the individual potencies of each of the active anesthetic ingrediens.
3. An anesthetic process in accordance with claim 1 , further comprising:
grouping the active anesthetic ingredients into different classes based on action mechanisms;
combining the potencies for each of the active anesthetic ingredients in each class to determine a class potency;
determining an interaction relationship between the different classes of active anesthetic ingredients;
combining the class potencies according to the interaction relationship to obtain the combined potency of all the plurality of active anesthetic ingredients.
4. An anesthetic process in accordance with claim 3 , wherein:
said step of determining an interaction relationship is performed using a mathematical formula.
5. An anesthetic process in accordance with claim 1 , wherein:
said combined potency of the active anesthetic ingredients are based on a mean anesthetic efficacy of the active ingredients used and an interaction term.
6. An anesthetic system comprising:
an anesthetic administrating device capable of administering a plurality of anesthetics to a patient;
information management system receiving data from said anesthetic administrating device;
a plurality of models connected to said information management system, said models:
determining a concentration of each of the active anesthetic ingredients at a site of action;
determining a potency of each of the active anesthetic ingredients from the determined concentrations of each active anesthetic ingredient at the site of action;
determining an interaction relationship between each of the active anesthetic ingredients;
combining the potencies according the interaction relationship to obtain a combined potency of all the plurality of active anesthetic ingredients;
converting said combined potency to a Noxious Stimulus Response Index (NSRI), said NSRI being a one-dimensional parameter and having a full scale range with a first endpoint of said range indicating an alert and non-anesthetized patient, and with a second endpoint of said range indicating a deepest anesthesia, said NSRI being calculated by
NSRI
=
100
*
(
1
-
(
N
/
N
′
)
sl
1
+
(
N
/
N
′
)
sl
)
where:
N is the combined potency;
N′ is a specific value at which an NSRI of 50% is reached; and
sl is a slope factor for the transformation of N into NSRI;
a display connected to said models for displaying the NSRI on said display.