Tracheal tube with colorimetric CO
Tracheal tubes having an integrated calorimetric CO 2 indicator are provided. In certain embodiment, the integrated CO 2 indicator is selectively sealed from the remainder of the tracheal tube by a removable sterilization barrier. Also provided are CO 2 indicators that exhibit long lasting, breath-to-breath dynamic color change and are storage stable. The devices and compositions of the invention find use in a variety of applications, e.g. in emergent intubation of a subject. Also provided are methods of making the devices and compositions, as well as kits that include the devices and/or compositions of the invention.
1. A tracheal tube device comprising:
a) an elongated tubular element having:
i) a distal region configured for placement to access the trachea of a subject;
ii) a proximal region, wherein the distal region and the proximal region are portions of the same elongated tubular element; and
iii) a longitudinal axis extending from the distal region to the proximal region;
b) a CO 2 indicator present on an inner surface of said elongated tubular element at said proximal region and integrated into the tubular element; and
c) a removable sterilization barrier, wherein the removable sterilization barrier is a film that has a major extension from a proximal end to a distal end of the CO 2 indicator along the longitudinal axis and selectively seals the CO 2 indicator from the remainder of the tracheal tube device and is configured to be removed from the tracheal tube device before the device is used to intubate a subject without removing the CO 2 indicator.
2. The tracheal tube device according to claim 1 , wherein said film covers inner and outer surfaces of said proximal region of said elongated tubular element.
3. The tracheal tube device according to claim 1 , wherein said CO 2 indicator comprises a CO 2 sensitive chemical reagent present on a solid support.
4. The tracheal tube device according to claim 3 , wherein said solid support is a flexible solid support.
5. The tracheal tube device according to claim 4 , wherein said flexible solid support comprises a cellulosic material.
6. The tracheal tube device according to claim 4 , wherein said solid support is configured as a tube dimensioned to fit inside of said elongated tubular element at said proximal region.
7. The tracheal tube device according to claim 1 , wherein said CO 2 indicator exhibits breath to breath dynamic color change.
8. The tracheal tube device according to claim 1 , wherein said CO 2 indicator is storage stable.
9. The tracheal tube device according to claim 1 , wherein all of said device but said CO 2 indicator has been sterilized.
10. The tracheal tube device according to claim 1 , wherein said CO 2 indicator is a long lasting rapid response reversible CO 2 indicator that exhibits breath to breath dynamic color change.
11. The tracheal tube device according to claim 10 , wherein said CO 2 indicator comprises a CO 2 sensitive chemical reagent present on a solid support.
12. The tracheal tube device according to claim 11 , wherein said solid support is a flexible solid support.
13. The tracheal tube device according to claim 12 , wherein said flexible solid support comprises a cellulosic material.
14. The tracheal tube device according to claim 13 , wherein said solid support is configured as a tube dimensioned to fit inside of the elongated tubular element at a proximal region thereof.
15. The tracheal tube device according to claim 11 , wherein said chemical reagent comprises a pH sensitive indicator dye.
16. The tracheal tube device according to claim 15 , wherein said pH sensitive indicator dye comprises a cresol.
17. The tracheal tube device according to claim 16 , wherein said dye comprises first and second cresols.
18. The tracheal tube device according to claim 17 , wherein said first cresol is m-cresol purple and said second cresol is cresol red.
19. The tracheal tube device according to claim 11 , wherein said chemical reagent further comprises a phase transport enhancer.
20. The tracheal tube device according to claim 19 , wherein said phase transport enhancer is a quaternary ammonium compound.
21. The tracheal tube device according to claim 20 , wherein said cationic quaternary ammonium compound is TBAH.
22. The tracheal tube device according to claim 1 , wherein the CO 2 indicator is positioned between a first hydrophobic gas permeable barrier and a second transparent barrier.
23. The tracheal tube device according to claim 1 , wherein the removable sterilization barrier is configured to prevent a sterilization component from reaching the CO 2 indicator that is selectively sealed by the barrier.
24. The tracheal tube device according to claim 23 , wherein the sterilization component is a gas.
25. The tracheal tube device according to claim 24 , wherein the gas is ethylene oxide.
26. The tracheal tube device according to claim 1 , wherein the removable sterilization barrier comprises butyl rubber, polyethylene terephthalate, or polytetrafluoroethylene.
27. The tracheal tube device according to claim 1 , wherein the removable sterilization barrier is configured to be removed from the tracheal tube device in a single motion when the tracheal tube device is removed from a sterile package.
28. The tracheal tube device according to claim 27 , wherein the removable sterilization barrier and the sterile package are formed as one unit.