IP Library › Patent Application 12139222
Patent Application
App. No. 12/139,222

Reactivity of Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors Containing Conjugated Dienes with Phenolic Antioxidants in the Solid-State

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Quick Facts
Patent No.
US None
App. No.
12/139,222
Abstract

The object of this invention was to probe the reactivity of lovastatin, simvastatin, pravastatin, and mevastatin in the solid-state without radical initiators in order to determine the antioxidant that provided the best stability for the statin. Phenolic antioxidants were evaluated.

Claims (3)

1 . The use of butylated hydroxy anisole (BHA) to reduce oxidative degradation of simvastatin.

2 . The use of propyl gallate to reduce oxidative degradation of simvastatin.

3 . The use of α-tocopherol to reduce oxidative degradation of simvastatin.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2008
From: LANG, RUSSELL F.
To: ABBOTT LABORATORIES
Reel/Frame 021461/0331 →