PFKB3 inhibitor for the treatment of a proliferative cancer
View Patent ↗A methods and compounds for inhibiting 6-phosphofructo-2-kinase /fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.
1. A method of reducing proliferative capacity in a cancer cell, the method comprising contacting the cell with an effective amount of the compound having the structural formula:
2. A method of treating a cancer in a subject in need of treatment thereof, the method comprising administering to the subject an effective amount of a compound having the structural formula:
3. The method of claim 2 , wherein the subject is a mammal.
4. The method of claim 2 , wherein the cancer is selected from the group consisting of breast cancer, lung cancer, cervical cancer, skin cancer, and leukemia.
5. The method of claim 2 , further comprising administering to the subject one or more additional therapeutic compounds.
6. The method of claim 5 , wherein the one or more additional therapeutic compounds are selected from the group consisting of cisplatin and paclitaxel.