IP Library › Granted Patent US 7,517,874

Granted Patent B2

US 7,517,874 · App. 12/142,846 · Granted Apr 14, 2009

Substituted imidazo[1,5-a][1,4]diazepines and imidazo[1,5-a]pyrazines as cannabinoid receptor agonists for the treatment of pain

Assignee: Cara Therapeutics, Inc.

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Patent No.: US 7,517,874
App. No.: 12/142,846
Granted: Apr 14, 2009
Kind: B2

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Abstract

The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

Claims (664)

1. A compound having the structure of formula I:

or a pharmaceutically acceptable salt, acid salt or stereoisomer thereof, wherein:

Y is selected from the group consisting of NR a and N + R 1 R 2 X − ;

Z is selected from the group consisting of a bond, —(CH 2 ) p , —CH═CH—, —C≡C—, and —CO—;

R a is selected from the group consisting of —H, C 1 -C 8 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, aryl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkenyl, —SO 2 R 3 , —COR 3 , —CONR 3 R 4 , —CSNR 3 R 4 , —COOR 3 and —(CH 2 ) q heterocyclyl, wherein the alkyl, cycloalkyl, cycloalkenyl, aryl and heterocyclyl of R a are each optionally substituted with one to four substituents independently selected from the group consisting of halo, —OH, oxo, —NH 2 , —NO 2 , —CN, —COOH, —COR 3 , —OCF 3 , —CF 3 , C 1 -C 6 alkyl, C 1 -C 4 alkoxy, C 3 -C 8 cycloalkyl, phenyl, trifluoromethoxy and trifluoromethyl;

R b is selected from the group consisting of C 1 -C 8 alkyl, C 2 -C 8 alkenyl, aryl, —NR 5 R 6 ,

and

wherein the alkyl, alkenyl and aryl of R b are each optionally substituted with one to three substituents independently selected from the group consisting of C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 3 -C 6 cycloalkyl, C 1 -C 4 alkoxy, aryl, 5-, 6-, and 7-membered heterocyclyl, halo, —OH, —NH 2 , —CN and —NO 2 ;

R c is selected from the group consisting of halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, C 3 -C 8 cycloalkenyl, C 1 -C 4 alkoxy, aryl, 5-, 6-, 7-, and 8-membered monocyclic heterocyclyl, 9-, and 10-membered bicyclic heterocyclyl; wherein the alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, C 3 -C 8 cycloalkenyl, aryl, 5-, 6-, 7-, 8-membered monocyclic heterocyclyl and 9- and 10-membered bicyclic heterocyclyl of R c are optionally substituted with one to five substituents independently selected from the group consisting of C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, C 3 -C 6 cycloalkyl, C 4 -C 8 cycloalkenyl, halo, —OH, —NH 2 , (A)(A′)(A″)(A′″)aryl, (A)(A′)(A″)(A′″)heterocyclyl, NR 14 R 15 , (CH 2 ) p NR 14 R 15 , —CN, —NO 2 , oxo, —COOR 14 , SOR 14 , SO 2 R 14 , SO 2 NR 14 R 15 , NR 15 SO 2 R 16 , COR 14 , CONR 14 R 15 and NR 15 COR 16 ; wherein (A), (A′), (A″) and (A′″) are each an independently selected from the group consisting of —H and C 1 -C 4 alkyl and each heterocyclyl of (A)(A′)(A″)(A′″)heterocyclyl is independently selected from the group consisting of 5-, 6-, 7- and 8-membered monocyclic heterocyclyl and 9- and 10-membered bicyclic heterocyclyl;

R 1 and R 2 are each independently C 1 -C 4 alkyl;

R 3 and R 4 , when either or both are present, are each independently selected from the group consisting of —H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkenyl, aryl, 4-, 5-, 6-, 7- and 8-membered heterocyclyl; wherein R 3 and R 4 that are not H are each independently optionally substituted with one to three substituents independently selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 acyl, aryl, 5-, 6-, 7- and 8-membered monocyclic heterocyclyl, and 9- and 10-membered bicyclic heterocyclyl, —NH 2 , —NO 2 , —CN, —OH, —COOH, oxo, and halo; provided that if R a is SO 2 R 3 , then R 3 is not —H; alternatively, R 3 and R 4 taken together with the nitrogen atom to which they are bonded form a heterocyclyl selected from the group consisting of 4-, 5-, 6-, 7- and 8-membered heterocyclyl;

R 5 is selected from the group consisting of —H, C 1 -C 4 alkyl and C 1 -C 4 haloalkyl; wherein the alkyl and haloalkyl of R 5 are optionally substituted with one to four substituents independently selected from the group consisting of C 1 -C 4 alkoxy, —OH, —NH 2 and —CN;

R 6 is selected from the group consisting of —H, —CR 10 R 11 R 12 , —CR 10 R 11 COR 13 , C 1 -C 8 alkyl, C 3 -C 10 cycloalkyl, aryl, 5-, 6-, 7-, 8-membered monocyclic heterocyclyl, and 9-, 10-membered bicyclic heterocyclyl; wherein the alkyl, cycloalkyl, aryl, and heterocyclyl of R 6 are optionally substituted with one to three substituents independently selected from the group consisting of C 1 -C 4 alkyl, aryl, halo, —OH, C 1 -C 4 alkoxy, C 1 -C 4 hydroxyalkyl, —COR 13 , —SO 2 R 11 , —SO 2 NR 8 R 9 , —NH 2 , —CN and —NO 2 ; alternatively, R 5 and R 6 taken together with the nitrogen atom to which they are bonded form a heterocyclyl selected from the group consisting of 5-, 6-, 7- and 8-membered monocyclic heterocyclyl, and 9- and 10-membered bicyclic heterocyclyl, which heterocyclyl substituent of R 6 is optionally substituted with one to two substituents independently selected from the group consisting of —CONR 1 R 2 and oxo;

R 7 is selected from the group consisting of-COR 3 , —COOR 3 , —SO 2 R 3 , and 5-, 6- and 7-membered heterocyclyl;

R 8 and R 9 are independently selected from the group consisting of —H, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 2 -C 4 alkenyl, C 3 -C 6 cycloalkyl, aryl, 5-, 6-, 7- and 8-membered monocyclic heterocyclyl, and 9- and 10-membered bicyclic heterocyclyl, halo, —OH, —CONH 2 , —NH 2 , —CN and —NO 2 ; alternatively: (i)R 8 and R 9 , taken together with the nitrogen atom to which they are bonded form a heterocyclyl ring which is optionally substituted with one to three substituents selected from the group consisting of C 1 -C 4 alkyl, halo, oxo and aryl; or (ii) R 8 and R 9 , taken together with the carbon atom to which they are bonded form a cycloalkyl which is optionally substituted with one to three substituents selected from the group consisting of C 1 -C 4 alkyl, halo, oxo and aryl;

R 10 is selected from the group consisting of —H and C 1 -C 4 alkyl;

R 11 is selected from the group consisting of —H, C 1 -C 8 alkyl, C 2 -C 6 alkenyl, C 2 -C 4 alkynyl, C 3 -C 10 cycloalkyl, aryl, 5-, 6-, 7- and 8-membered monocyclic heterocyclyl, and 9- and 10-membered bicyclic heterocyclyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, aryl and 5-, 6-, 7- and 8-membered monocyclic heterocyclyl, and 9- and 10-membered bicyclic heterocyclyl of R 11 are optionally substituted with one to three substituents independently selected from the group consisting of C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, aryl, and 5-, 6-, 7- and 8-membered monocyclic heterocyclyl, and 9- and 10-membered bicyclic heterocyclyl, halo, —OH, C 1 -C 4 alkoxy, —NH 2 , -guanidino, —CN, —NO 2 , oxo, —COOR 10 , —CONR 8 R 9 , —SO 2 NR 8 R 9 , —SR 10 , —SOR 1 and —SO 2 R 1 ;

R 12 is selected from the group consisting of —H, C 1 -C 4 alkyl and C 1 -C 4 hydroxyalkyl;

R 13 is selected from the group consisting of —OR 10 and —NR 8 R 9 ;

R 14 , R 15 and R 16 are each independently selected from the group consisting of —H, and C 1 -C 4 alkyl; alternatively, R 14 and R 15 taken together with the nitrogen atom to which they are bonded form a heterocyclyl selected from the group consisting of 5-, 6-, 7- and 8-membered monocyclic heterocyclyl, and 9- and 10-membered bicyclic heterocyclyl;

X − is an anionic counterion;

m is an integer selected from 1 and 2; p is an integer from 1 to 6; and q is zero or an integer from 1 to 4; and

provided that when R c is heterocyclyl, the heterocyclyl is directly bonded through a carbon atom of a ring of the heterocyclyl.

2. The compound according to claim 1 , wherein:

the anionic counterion is a halide ion;

R a is selected from the group consisting of —H, aryl, C 1 -C 6 alkyl, cyclopropyl, —SO 2 R 3 , —COR 3 , —CONR 3 R 4 , —CSNR 3 R 4 , —COOR 3 and —(CH 2 ) q heterocyclyl, wherein the alkyl, aryl and —(CH 2 ) q heterocyclyl of R a are optionally substituted with one to three substituents independently selected from the group consisting of halo, —OH, C 1 -C 4 alkyl, cyclopropyl, acetyl and phenyl;

R 3 is selected from the group consisting of C 1 -C 5 alkyl, cyclopropyl, aryl and 5-, and 6-membered heterocyclyl; wherein the aryl of R 3 is optionally substituted with one to three substituents selected from the group consisting of —CN, —NO 2 , halo and —CF 3 ; and q is 0 or 1.

3. The compound according to claim 2 , wherein R a is selected from the group consisting of —H or C 1 -C 4 alkyl, 4-fluorophenylsulfonyl, and —(CH 2 ) q pyrimidinyl; wherein the alkyl of R a , is optionally substituted with cyclopropyl.

4. The compound according to claim 3 , wherein R a is —CH 3 .

5. The compound according to claim 1 , wherein:

R b is selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, NR 5 R 6 ,

and

wherein the alkyl of R b is optionally substituted with aryl;

R 3 is aryl;

R 5 is —H;

R 6 is selected from the group consisting of —CR 10 R 11 R 12 , —CR 10 R 11 COR 13 , C 1 -C 6 alkyl, C 1 -C 10 alkyl, aryl and 5-, 6-, 7-, 8-membered monocyclic heterocyclyl; wherein the alkyl, cycloalkyl, aryl, and heterocyclyl of R 6 are optionally substituted with one to three substituents independently selected the group consisting of —CH 3 , aryl, halo and —OH; wherein the heterocyclyl formed of R 6 is optionally substituted with —CONR 1 R 2 ;

R 7 is selected from the group consisting of —COR 3 and 6-membered heterocyclyl;

R 8 and R 9 are independently selected from the group consisting of —H, C 1 -C 4 alkyl, C 1 -C 2 haloalkyl, C 3 -C 4 cycloalkyl, —CONH 2 , 5- and 6-membered monocyclic heterocyclyl, and 9- and 10-membered bicyclic heterocyclyl; alternatively, R 8 and R 9 , taken together, form a carbocyclyl or heterocyclyl ring, which is optionally substituted with one to two substituents independently selected from the group consisting of —CH 3 , halo, oxo and aryl;

R 10 is selected from the group consisting of —H and C 1 -C 4 alkyl;

R 11 is selected from the group consisting of —H, C 1 -C 5 alkyl, C 3 -C 10 cycloalkyl, aryl, 5- and 6-membered monocyclic heterocyclyl; wherein the alkyl, cycloalkyl, aryl, and heterocyclyl of R 11 are optionally substituted with one to three substituents independently selected from the group consisting of C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, aryl, 5- and 6-membered monocyclic heterocyclyl, and 9-membered bicyclic heterocyclyl, halo, —OH, —COOR 10 , —CONR 8 R 9 and —SO 2 NR 8 R 9 ; and m is 1 or 2.

6. The compound according to claim 5 , wherein R b is NR 5 CHR 11 COR 13 .

7. The compound according to claim 6 , wherein R b is NHCHR 11 CONR 8 R 9 .

8. The compound according to claim 7 , wherein R b is NHCHR 11 CONHCH 3 .

9. The compound according to claim 8 , wherein R b is NHCH(tBu)CONHCH 3 .

10. The compound according to claim 1 , wherein:

R c is selected from the group consisting of halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkenyl, aryl, 5- and 6-membered monocyclic heterocyclyl and 9- and 10-membered bicyclic heterocyclyl; wherein the alkyl, alkenyl, cycloalkyl, aryl and heterocyclyl of R c are optionally substituted with one to three substituents independently selected from the group consisting of C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 3 -C 6 cycloalkyl, aryl, heterocyclyl, halo, —OH, —NH 2 , NR 14 R 15 , (CH 2 ) p NR 14 R 15 , —CN, —NO 2 , oxo, —COOR 14 , —SO 2 R 14 , —SO 2 NR 14 R 15 , —NR 15 SO 2 R 16 , —COR 14 , —CONR 14 R 15 and —NR 15 COR 16 ; wherein the heterocyclyl of the substituent of R c is selected from the group consisting of 5-, 6- and 7-membered heterocyclyl; and

m is 1 or 2.

11. The compound according to claim 10 , wherein:

Z is selected from the group consisting of a bond, —(CH 2 ) p , and —CH═CH—; and

R c is selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkenyl, phenyl and 5- and 6-membered monocyclic heterocyclyl; wherein the alkyl, cycloalkyl, cycloalkenyl, phenyl and heterocyclyl of R c are optionally substituted with one to two substituents independently selected from the group consisting of C 1 -C 4 alkyl, C 1 -C 4 alkoxy, —OCF 3 , —CF 3 , C 3 -C 6 cycloalkyl, -halo, —OH, and —CN; and the cycloalkyl, cycloalkenyl, phenyl and heterocyclyl of R c are further optionally substituted with an additional halo substituent.

12. The compound according to claim 11 , wherein Z is a bond and R c is phenyl; wherein the phenyl is optionally substituted with a substituent independently selected from the group consisting of halo, —CH 3 , —OCH 3 , —CF 3 and —CN; and the phenyl is optionally substituted with an additional one to two halo substituents.

13. The compound according to claim 12 wherein R c is selected from the group consisting of phenyl, 3-chloro-4-methylphenyl, 2-chloro-4-fluorophenyl, 2-fluoro-4-chlorophenyl, 2-fluoro-4-bromophenyl, 2-fluoro-5-chlorophenyl, 2,4-difluorophenyl, 2,5-difluorophenyl, 3,5-difluorophenyl, 3,4-difluorophenyl, 2-fluoro-4-methylphenyl, 2-fluoro-5-methylphenyl, 2-fluoro-3-methoxyphenyl, 2-fluoro-4-methoxyphenyl, 2-fluoro-4-trifluoromethylphenyl, 2-fluoro-5-trifluoromethylphenyl, 3-cyano-4-fluorophenyl, 2-fluoro-4-methyl-5-chlorophenyl, 2,4-difluoro-5-chlorophenyl, 2,4,5-trifluorophenyl, 3,4,5-trifluorophenyl, 2,5-difluoro-4-methoxyphenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3-methyl-4-fluorophenyl, 2-fluoro-3-chlorophenyl, 3-trifluoromethylphenyl, 3-methylphenyl, 3-fluoro-4-methylphenyl, 3-methyl-4-fluorophenyl, 3-chloro-4-fluorophenyl and 3-fluoro-4-chlorophenyl.

14. The compound according to claim 13 wherein R c is selected from the group consisting of phenyl, 2-fluoro-4-chlorophenyl, 2-fluoro-4-bromophenyl, 2,4-difluoro-5-chlorophenyl, and 2,4,5-trifluorophenyl.

15. The compound according to claim 11 , wherein:

Z is a bond; and

R c is selected from the group consisting of C 2 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 3 -C 6 alkenyl, C 3 -C 7 cycloalkenyl, 5- and 6-membered monocyclic heterocyclyl, wherein the alkyl, cycloalkyl, cycloalkenyl and heterocyclyl of R c are optionally substituted with one to two groups independently selected from the group consisting of C 1 -C 4 alkyl, —OCH 3 , —CF 3 , C 3 -C 6 cycloalkyl, halo, —OH, and —CN.

16. The compound according to claim 1 , wherein R c is selected from the group consisting of ethyl, n-propyl, isopropyl, 1,2-dimethylpropyl, isobutyl, 3,3-dimethylbutyl, n-pentyl, n-hexyl, cyclopropyl, ethenyl, propen-1-yl, propen-2-yl, 2-methylpropen-1-yl, 3,3-dimethylbut-2-en-2-yl, 2-methylpropen-1-yl, 1-penten-1-yl, 1-hexen-1-yl, 3-methoxy, cyclopropyl, cyclopentyl, cyclopentenyl, cyclohexyl, 4-methylcyclohexyl, 4,4,-difluorocyclohexyl, 1,4-dioxaspiro[4,5]dec-7-en-8-yl, cyclohexen-1-yl, 4-methylcyclohexen-1-yl, 4-tert-butyl-cyclohexen-1-yl, cycloheptyl, cyclohepten-1-yl, thiophen-3-yl and 2-(thiophen-3-yl)ethen-1-yl.

17. The compound according to claim 10 , wherein R c is selected from the group consisting of dihydropyran-2-yl, tetrahydropyran-2-yl, dihydropyran-4-yl, piperidin-4-yl, pyridin-2-yl, 3,4-dihydropiperidin-4-yl, pyridin-3-yl, pyridin-4-yl, 3-fluoro-pyridin-4-yl, pyrimidin-5-yl, 1-methylpyrazol-4-yl, 3,5-dimethylisoxazol-4-yl, thiophen-2-yl, thiophen-3-yl, 4-methylthiophen-3-yl, furan-2-yl, 5-methylfuran-2-yl, furan-3-yl, thiazol-2-yl, benzofuran-2-yl, benzothiophen-3-yl, benzo[d][1,3]dioxol-5-yl and 2,3-dihydrobenzo[b][1,4]dioxin-6-yl.

18. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable diluent, excipient or carrier.

19. A method of prophylaxis or treatment of a cannabinoid receptor-associated disease or condition in a mammalian subject, the method comprising administering to the subject a compound according to claim 1 , wherein the cannabinoid receptor-associated disease or condition is selected from the group consisting of visceral pain, inflammatory pain and neuropathic pain.

20. The compound selected from the group consisting of:

(S)-tert-butyl 1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-3-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5 ,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-(trifluoromethyl)-phenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-(trifluoromethyl)-phenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3 ,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-fluoro-3-methyl-phenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-m-tolyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(4-chlorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(2-chlorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3 ,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(thiophen-3-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(furan-3-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-benzyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(pyridin-3-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(furan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3 ,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(thiophen-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(1-methyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(3-chlorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(pyrimidin-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(benzo[b]thiophen-3-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5,6,7 ,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-methylthiophen-3-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

(R)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

N-neopentyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide, morpholino(3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl)methanone;

(R)-N-(3,3-dimethylbutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

(S)-N-(3,3-dimethylbutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

(S)-N-(1-(methylamino)-1-oxopropan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

N-(3-hydroxy-2,2-dimethylpropyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

tert-butyl 3-phenyl-1-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-ylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

(S)-tert-butyl 3-phenyl-1-(1-phenylethylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

tert-butyl 3-phenyl-1-(phenylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

tert-butyl 3-(4-chiorophenyl)-1-(isopentylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

(S)-tert-butyl 3-(4-chiorophenyl)-1-(1-hydroxy-3,3-dimethylbutan-2-ylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

tert-butyl 3-phenyl-1-(piperidin-1-ylcarbamoyl)-5,6-dihydroimidazo[1,5-a]-pyrazine-7(8H)-carboxylate;

tert-butyl 1-(cyclohexylcarbamoyl)-3-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

(R)-tert-butyl 1-(1-cyclohexylethylcarbamoyl)-3-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

tert-butyl 3-phenyl-1-((tetrahydro-2H-pyran-4-yl)methylcarbamoyl)-5,6-dihydro-imidazo[1,5-a]pyrazine-7(8H)-carboxylate;

3-phenyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

(S)-3-phenyl-N-(1-phenylethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

N,3-diphenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide,

3-(4-chlorophenyl)-N-isopentyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(4-chlorophenyl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-phenyl-N- (piperidin-1-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(R)-N-(1-cyclohexylethyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-phenyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N-cyclohexyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(4-chlorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(R)-N-(3,3-dimethylbutan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethylbutan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

(R)-N-(3,3-dimethylbutan-2-yl)-7-isobutyl-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethylbutan-2-yl)-7-isobutyl-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(3,3-dimethylbutyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-neopentyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(cyclopropylmethyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-methyl-N-neopentyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-isobutyl-N-neopentyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-7-isobutyl-3-phenyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-benzyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-7-(pyrimidin-5-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-7-(pyridin-3-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(furan-2-ylmethyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-((1-methyl-1H-pyrazol-5-yl)methyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-((1-methyl-1H-pyrazol-4-yl)methyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(R)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(R)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-7-isobutyl-3-phenyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl)(morpholino)-methanone;

(7-isobutyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl)(morpholino)-methanone;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-((1-methyl-1H-pyrrol-2-yl)methyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-7-(thiazol-2-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(thiophen-3-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(cyclopropylmethyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(thiophen-3-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(benzo[b]thiophen-3-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(pyrimidin-5-ylmethyl)-3-(thiophen-3-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-(methylamino)-1-oxopropan-2-yl)-3-phenyl-7-(pyrimidin-5-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-methyl-N-(1-(methylamino)-1-oxopropan-2-yl)-3-phenyl-5,6,7,8-tetra-hydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-7-isobutyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(4-methyl-thiophen-3-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

N-(3-hydroxy-2,2-dimethylpropyl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

7-(cyclopropylmethyl)-N-(3-hydroxy-2,2-dimethylpropyl)-3-phenyl-5,6,7,8-tetra-hydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(cyclopropylmethyl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-isopropyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-methyl 3,3-dimethyl-2-(7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamido)butanoate;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(cyclopropylmethyl)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-7-isopropyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-7-isobutyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(ethylsulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(methylsulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(4-fluorophenyl-sulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(isopropylsulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(isobutylsulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-7-(phenyl-sulfonyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(2-nitrophenylsulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(2-fluorophenyl-sulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(3-fluorophenyl-sulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(cyclopropylsulfonyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(4-fluorophenylsulfonyl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenyl-7-(phenylsulfonyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-(4-fluorophenylsulfonyl)-N-neopentyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N-neopentyl-3-phenyl-7-(phenylsulfonyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

(7-(4-fluorophenylsulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl)(morpholino)methanone;

(S)-7-(4-chlorophenylsulfonyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-7-(4-(trifluoro-methyl)phenylsulfonyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(4-cyanophenylsulfonyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(4-fluorophenyl-sulfonyl)-3-(thiophen-3-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(4-fluorophenylsulfonyl)-N-(1-(methylamino)-1-oxopropan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(R)-N-(1-cyclohexylethyl)-7-(ethylsulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

7-(ethylsulfonyl)-3-phenyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(ethylsulfonyl)-3-phenyl-N-(1-phenylethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide

7-(ethylsulfonyl)-N,3-diphenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-(ethylsulfonyl)-3-phenyl-N-(piperidin- l-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

3-(4-chlorophenyl)-7-(ethylsulfonyl)-N-isopentyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

7-(ethylsulfonyl)-3-phenyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

N-cyclohexyl-7-(ethylsulfonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

7-(cyclopropanecarbonyl)-3-phenyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-benzoyl-3-phenyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

3-phenyl-7-(tetrahydrofuran-3-carbonyl)-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-(furan-2-carbonyl)-3-phenyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-phenyl-7-pivaloyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(cyclopropanecarbonyl)-3-phenyl-N-(1-phenylethyl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-benzoyl-3-phenyl-N-(1-phenylethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

(S)-7-(cyclopropanecarbonyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-benzoyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(furan-2-carbonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-(cyclopropanecarbonyl)-N,3-diphenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-benzoyl-3-(4-chlorophenyl)-N-isopentyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

3-(4-chlorophenyl)-7-(cyclopropanecarbonyl)-N-isopentyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(R)-N-(1-cyclohexylethyl)-7-(cyclopropanecarbonyl)-3-phenyl-5,6,7,8-tetra-hydroimidazo[1,5-a]pyrazine-1-carboxamide;

(R)-N-(1-cyclohexylethyl)-3-phenyl-7-pivaloyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

7-(cyclopropanecarbonyl)-3-phenyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-phenyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-7-(tetrahydrofuran-3-carbonyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

N-cyclohexyl-7-(cyclopropanecarbonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N-cyclohexyl-3-phenyl-7-pivaloyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

N-cyclohexyl-7-(furan-3-carbonyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N-((R)-1-cyclohexylethyl)-3-phenyl-7-(tetrahydrofuran-3-carbonyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(R)-N-(1-cyclohexylethyl)-7-(2-hydroxyethyl)-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

N-cyclohexyl-3-phenyl-7-((tetrahydrofuran-3-yl)methyl)-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

7-isobutyl-3-phenyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

7-(2-hydroxyethyl)-3-phenyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-ethyl-3-phenyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-isobutyl-3-phenyl-N-(1-phenylethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

(S)-7-(2-hydroxyethyl)-3-phenyl-N-(1-phenylethyl)-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

(S)-7-ethyl-3-phenyl-N-(1-phenylethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-isobutyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-ethyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-isobutyl-N,3-diphenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-(2-hydroxyethyl)-N,3-diphenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-ethyl-N,3-diphenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(2-hydroxyethyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

N,3-diphenyl-7-propyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-isobutyl-3-phenyl-N-(piperidin-1-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-(2-hydroxyethyl)-3-phenyl-N-(piperidin-1-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide; 3-(4-chlorophenyl)-7-isobutyl-N-isopentyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

3-(4-chlorophenyl)-7-ethyl-N-isopentyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-(4-chlorophenyl)-7-(2-hydroxyethyl)-N-isopentyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

(S)-3-(4-chlorophenyl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-7-isobutyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(4-chlorophenyl)-7-ethyl-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(4-chlorophenyl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-7-(2-hydroxyethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(R)-N-(1-cyclohexylethyl)-7-isobutyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

(R)-N-(1-cyclohexylethyl)-7-ethyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N-cyclohexyl-7-isobutyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

N-cyclohexyl-7-(2-hydroxyethyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

7-isobutyl-3-phenyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

7-ethyl-3-phenyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

7-(2-hydroxyethyl)-3-phenyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(R)-7-acetyl-N-(1-cyclohexylethyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N7-isopropyl-3-phenyl-N 1-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6-dihydro-imidazo[1,5-a]pyrazine-1,7(8H)-dicarboxamide;

(S)-7-acetyl-3-phenyl-N-(1-phenylethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine1-carboxamide; 7-acetyl-N,3-diphenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-acetyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-acetyl-3-phenyl-N-(piperidin- l-yl)-S ,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

7-acetyl-3-phenyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

7-acetyl-N-cyclohexyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

methyl 3-phenyl-1-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-ylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

(S)-methyl 3-phenyl-1-(1-phenylethylcarbamoyl)-5,6-dihydroimidazo[1,5-a]-pyrazine-7(8H)-carboxylate;

(S)-methyl 1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-3-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

methyl 3-phenyl-1-(phenylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

methyl 3-phenyl-1-(piperidin-1-ylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

methyl 3-(4-chlorophenyl)-1-(isopentylcarbamoyl)-5,6-dihydroimidazo[1,5-a]-pyrazine-7(8H)-carboxylate;

(S)-methyl 3-(4-chlorophenyl)-1-(1-hydroxy-3,3-dimethylbutan-2-ylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

(R)-methyl 1-(1-cyclohexylethylcarbamoyl)-3-phenyl-5,6-dihydroimidazo[1,5-a]-pyrazine-7(8H)-carboxylate;

methyl 3-phenyl-1-((tetrahydro-2H-pyran-4-yl)methylcarbamoyl)-5,6-dihydro-imidazo[1,5-a]pyrazine-7(8H)-carboxylate;

methyl 1-(cyclohexylcarbamoyl)-3-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-(3,3-dimethylbutanoyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-7-propionyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-7-pivaloyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-isobutyryl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N7-tert-butyl-N 1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine-1,7(8H)-dicarboxamide;

(S)-N1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-N7-propyl-5,6-dihydroimidazo[1,5-a]pyrazine-1,7(8H)-dicarboxamide;

(S)-N 1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N7,3-diphenyl-5,6-dihydroimidazo[1,5-a]pyrazine-1,7(8H)-dicarboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-7-(propyl-carbamothioyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-cyclopropyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-cyclopropyl-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-8-cyclopropyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)propyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)propyl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)propyl)-7-isobutyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-bromo-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(phenyl-ethynyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(pyridin-3-ylethynyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-methyl-N-(3-methyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-methyl-N-(2-(methylamino)-2-oxo-1-phenylethyl)-3-phenyl-5,6,7,8-tetra-hydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-(4-chloro-2-fluorophenyl)-7-methyl-N-(4- sulfamoylphenyl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

tert-butyl 4-(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamido)piperidine-1-carboxylate;

(4-benzoylpiperazin-1-yl) (3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazin-1-yl)methanone;

(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl) (4-(pyrimidin-2-yl)piperazin-1-yl)methanone;

5-chioro-1-(1-(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carbonyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one;

3-(4-chloro-2-fluorophenyl)-7-methyl-N-(1-(methylsulfonyl)piperidin-4-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

8-(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;

1-(1-(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carbonyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one;

3-(4-chloro-2-fluorophenyl)-7-methyl-N-(3-(methylcarbamoyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-(4-chloro-2-fluorophenyl)-7-methyl-N-(2-(methylcarbamoyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-(4-chloro-2-fluorophenyl)-7-methyl-N-(4-(methylcarbamoyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-(4-chloro-2-fluorophenyl)-7-methyl-N-(4-(morpholinosulfonyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

8-(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carbonyl)-2, 8-diazaspiro[4.5]decan-1-one;

8-(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carbonyl)-2-methyl-2, 8-diazaspiro[4.5]decan-1-one;

1-(1-(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carbonyl)piperidin-4-yl)indolin-2-one;

(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl)(4-(3,5-dimethyl-4H-1,2,4-triazol-4-yl)piperidin-1-yl)methanone;

methyl 3-((3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamido)methyl)benzoate;

1-(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carbonyl)-4-morpholinopiperidine-4-carboxamide.

(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl)(4-(morpholine-4-carbonyl)piperidin-1-yl)methanone;

1-(1-(3-(4-chloro-2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carbonyl)piperidin-4-yl)-4-phenyl-1H-imidazol-2(3H)-one;

3-(4-chloro-2-fluorophenyl)-7-methyl-N-((2-oxo-2,3-dihydro-1H-benzo-[d]imidazol-5-yl)methyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

N-(3-hydroxypropyl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N-(1-hydroxy-2-methylpropan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide; N-(1-hydroxypropan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N-(1-hydroxybutan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N-(1-hydroxypentan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N-((1,3-dioxolan-2-yl)methyl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]-pyrazine-1-carboxamide;

N-(1-(hydroxymethyl)cyclopentyl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine-1-carboxamide;

7-methyl-3-phenyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

7-methyl-N-((5-methylpyrazin-2-yl)methyl)-3-phenyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-cyclopentenyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(pyrimidin-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-fluoro-4-methyl-phenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(4-chloro-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-S ,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(quinolin-8-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(prop-1-enyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(5-chloro-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(2,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-4-methylphenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(2,5-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-5-methyl-phenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(pyridin-3-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(2-chlorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(4-cyanophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(2-(trifluoro-methyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-cyclohexenyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(2-methyl-prop-1-enyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluorophenyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(2-cyanophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(3-cyanophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(2,3-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(3,5-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3,3-dimethylbut-1-enyl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-methoxyprop-1-enyl)-7-methyl-S ,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(biphenyl-4-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[l,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-vinyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(prop-1-en-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(pent-1-enyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-cyclopropyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(4-methyl-cyclohex-1-enyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-(4-tert-butylcyclohex-1-enyl)-N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S,E)-3-cycloheptenyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S,E)-3-(2-cyclopropylvinyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(1,2,3,6-tetra-hydropyridin-4-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(4-chloro-2-fluorophenyl)-7-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(4-chloro-3-fluorophenyl)-7-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(3,4-difluorophenyl)-7-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-cyclopentenyl-7-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-(3,4-dihydro-2H-pyran-6-yl)-7-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3,3-dimethyl-2-(7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamido)butanoic acid;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-(3-tert-butyl-1,2,4-oxadiazol-5-yl)-2,2-dimethylpropyl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-(3-tert-butyl-1,2,4-oxadiazol-5-yl)-2,2-dimethylpropyl)-7-cyclopropyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(3-morpholinoprop-1-enyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(3-(piperidin-1-yl)prop-1-enyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(3-(pyrrolidin-1-yl)prop-1-enyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-benzoyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-N3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1,3-dicarboxamide;

3,3-dimethyl-1-(3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl)butan-1-one;

3,3-dimethyl-1-(7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl)butan-1-one;

3-methyl-1-(7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl)but-2-en-1-one;

1-(7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl)-4-phenyl-butan-1-one;

N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(hydroxy(phenyl)-methyl)-7-methyl-S ,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

3-(cyclopropyl(hydroxy)methyl)-N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(thiazol-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(6-chloropyridin-2-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-7-(6-chloropyrazin-2-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-7-(pyrazin-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(R)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-cyclopentyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-propyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-3-cyclohexyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-isobutyl-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(3-(piperidin-1-yl)propyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(3-(pyrrolidin-1yl)propyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-7-methyl-3-(3-morpholinopropyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-ethyl-7-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide;

(S)-1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-7,7-dimethyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-7-ium;

(S)-tert-butyl 1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-3-phenyl-6,7-dihydro-5H-imidazo[1,5-a][1,4]diazepine-8(9H)-carboxylate;

(S)-tert-butyl 3-(4-chloro-2-fluorophenyl)-1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-6,7-dihydro-5H-imidazo[1,5-a][1,4]diazepine-8(9H)-carboxylate;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-chloro-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-6,7,8 ,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-4

-methyl-phenyl)-6,7,8 ,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-ethyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-isopropyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-isobutyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-8-(cyclopropylmethyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-chloro-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-isobutyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-8-(cyclopropylmethyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-4-methylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-bromo-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-methoxyphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-3-(5-chloro-2-methoxyphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-cyanophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(thiophen-3-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3,5-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-p-tolyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(2-(trifluoro-methoxy)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-chloro-4-methylphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2-chloro-5-methylphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-styryl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2-chloro-4-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(trifluoro-methoxy)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-(trifluoro-methoxy)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-4-methyl-phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(benzo[d][1,3]dioxol-5-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-cyanophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-methoxy-2-methyiphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-3-(2,4-dimethoxypyrimidin-5-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-3-methoxyphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-fluoro-3-methylphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(pyridin-3-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(thiophen-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-methoxy-3-methyiphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-3-(benzofuran-2-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-methylthiophen-3-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(benzo[b]thiophen-3-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-chloro-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(5-chloro-2-fluoro-4-methylphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-4-methoxyphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-3-(2,5-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-fluoro-4-methylphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-;diazepine-1-carboxamide;

(S)-3-(5-chloro-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-5-methyiphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-3-(trifluoro-methyl)phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]-[1,4]diazepine-1-carboxamide;

N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-6-methoxy-phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-chloro-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2-chloro-4-methylphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluoro-4-(trifluoro-methyl)phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-3-(2,3-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(5-chloro-2,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(2,4,5-trifluoro-phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-chloro-4-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-chloro-3-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3,4,5-trifluoro-phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(prop-1-enyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(2-methyl-prop-1-enyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-morpholino-phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-(methyl-sulfonyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(naphthalen-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-(dimethylamino)-phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-(dimethylamino)-phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(biphenyl-3-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-fluoro-5-methoxy-phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(pyrrolidin-1-ylsulfonyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(morpholine-4-carbonyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-methyl 4-(1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepin-3-yl)-3-fluoro-benzoate;

(S)-tert-butyl 4-(1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepin-3-yl)-5,6-dihydro-pyridine-1(2H)-carboxylate;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-fluoro-3-(morpholine-4-carbonyl)phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-3-(4-(1H-pyrazol-1-yl)phenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(methylcarbamoyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-(4-methyl-piperazine-1-carbonyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-fluoro-3-methoxy-phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-(dimethylcarbamoyl)-phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(pyridin-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-cyclohexenyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3,3-dimethylbut-1-enyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-methoxyprop-1-enyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(2-(trifluoro-methyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(hex-i -enyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-(morpholine-4-carbonyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(pyridin-4-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-isopropyiphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-fluoro-4-methoxy-phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(5-carbamoyl-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxo-butan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-fluoro-3-(methyl-carbamoyl)phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-(methyl-carbamoyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(methyl-sulfonyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-(N,N-dimethyl-sulfamoyl)phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-S -(1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepin-3-yl)-2-fluorobenzoic acid;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-(dimethyl-carbamoyl)-phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]-[1,4]diazepine-1-carboxamide;

(S)-3-(biphenyl-2-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-tert-butylphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-acetylphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-carbamoyl-5-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(naphthalen-1-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-methoxy-5-(trifluoro-methyl)phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(2-fluorobiphenyl-4-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-(methyl-sulfonamido)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(methyl-sulfonamido)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-carbamoylphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-carbamoylphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2,5-difluoro-4-methoxyphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-cyano-4-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-(dimethyl-carbamoyl)-3-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-carbamoyl-3-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-(5-oxopyrazolidin-3-yl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-3-(3-carbamoyl-4-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-vinyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2-carbamoylphenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S )-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(1H-pyrazol-4-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-chlorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(pent-1-enyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-cyclopropyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-3-(2-cyclopropylvinyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(trifluoro-methyl)phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S,E)-3-(2-cyclohexylvinyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(furan-3-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(prop-1-en-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3,5-dimethylisoxazol-4-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(5-methylfuran-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S )-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(quinolin-8-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-3-(3-cyclopentyiprop-1-enyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(2-(thiophen-3-yl)vinyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S )-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(1-methyl-1H-pyrazol-4-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S )-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(1,4-dioxaspiro-[4.5]dec-7-en-8-yl)-6,7,8,9-tetrahydro-5H-imidazo[i,5-a][1,4]diazepine-1-carboxamide;

N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-methyl-cyclohex-1-enyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

3-(4-tert-butylcyclohex-1-enyl)-N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-fluoropyridin-4-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3,4-dihydro-2H-pyran-6-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3,3,3-trifluoro-prop-1-en-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-methylbut-2-en-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(1-phenyl-vinyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-cyclopentenyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-3-cycloheptenyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-phenylprop-1-enyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-benzyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-(ethylsulfonyl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-8-benzoyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-8-acetyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-(4-fluoro-phenylsulfonyl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-methyl 3,3-dimethyl-2-(3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamido)butanoate;

(S)-methyl 2-(3-(2-fluoro-4-methylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]-[1,4]diazepine-1-carboxamido)-3,3-dimethylbutanoate;

(S)-methyl 3,3-dimethyl-2-(8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo-[1,5-a][1,4]diazepine-1-carboxamido)butanoate;

(S)-methyl 2-(8-isopropyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]-[1,4]diazepine-1-carboxamido)-3,3-dimethylbutanoate;

(S)-methyl 2-(3-(2-fluoro-4-methylphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamido)-3,3-dimethylbutanoate;

(S)-methyl 2-(8-(cyclopropylmethyl)-3-(2-fluoro-4-methylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamido)-3,3-dimethylbutanoate;

(S)-3,3-dimethyl-2-(8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamido)butanoic acid;

(S)-N-(1-(isopropylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-oxo-1-(propylamino)butan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-(isobutylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-(2-methoxyethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-(2-fluoroethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-(cyclopropylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-(ethylamino)-3,3-dimethyl-1-oxobutan-2-yl) -8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-oxo-1-((tetrahydro-2H-pyran-4-yl)methylamino)butan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-(cyclobutylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-8,8-dimethyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepin-8-ium;

(S)-3-(4-chloro-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-(pyrimidin-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-8-(pyrimidin-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-pentyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-propyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-isobutyl-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-cyclohexyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3,3-dimethylbutyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-methoxypropyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2-cyclopropylethyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-hexyl-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-ethyl-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2-cyclohexylethyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-cyclopentylpropyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(2-(thiophen-3-yl)ethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-isopropyl-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-cyclopentyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-cycloheptyl-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(4-methyl-cyclohexyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-morpholino-propyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(piperidin-1-yl)propyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(pyrrolidin-1-yl)propyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(piperidin-4-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(1,1,1-trifluoro-propan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(1-phenylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-methylbutan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-hydroxybutyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-morpholino-prop-1-enyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]-[1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(piperidin-1-yl)prop-1-enyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-(3-(pyrrolidin-1-yl)prop-1-enyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxami

(S,E)-3-(3-(diethylamino)prop-1-enyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]-[1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(3-(dimethylamino)prop-1-enyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S,E)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-3-(4-hydroxybut-1-enyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-2-(8-(tert-butoxycarbonyl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamido)-3,3-dimethylbutanoic acid;

(S)-2-(8-(tert-butoxycarbonyl)-3-(2-fluoro-4-methylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamido)-3,3-dimethylbutanoic acid;

(S)-tert-butyl 1-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propylcarbamoyl)-3-phenyl-6,7-dihydro-5H-imidazo[1,5-a][1,4]diazepine-8(9H)-carboxylate;

(S)-tert-butyl 1-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propylcarbamoyl)-3-(2-fluoro-4-methylphenyl)-6,7-dihydro-5H-imidazo[1,5-a][1,4]diazepine-8(9H)-carboxylate;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-3-(2-fluoro-4-methylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-3-(2-fluoro-4-methylphenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-3-(2-fluoro-4-methyl-phenyl)-8-isopropyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-8-ethyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)-8-isopropyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-chloro-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-(piperidin-4-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-8-(1-acetylpiperidin-4-yl)-3-(4-chloro-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4,4-difluorocyclohexyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-chloro-2-fluorophenyl)-8-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-fluorophenyl)-8-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-fluorophenyl)-8-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2,5-difluorophenyl)-8-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-8-methyl-N-(4-methyl-1-(methyl-amino)-1-oxopentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-3-(2,4-difluorophenyl)-8-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3,4-difluorophenyl)-8-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(5-chloro-2-fluorophenyl)-8-methyl-N-(4-methyl-1-(methylamino)-1-oxo-pentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-chloro-4-fluorophenyl)-8-methyl-N-(4-methyl-1-(methylamino)-1-oxo-pentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-8-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-3-(2,4,5-trifluoro-phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(5-chloro-2,4-difluorophenyl)-8-methyl-N-(4-methyl-1-(methylamino)-1-oxo-pentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-cyclohexyl-8-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide

(S)-N-(1-cyclohexyl-2-(methylamino)-2-oxoethyl)-8-methyl-3-(2,4,5-trifluoro-phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(5-chloro-2,4-difluorophenyl)-N-(1-cyclohexyl-2-(methylamino)-2-oxoethyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-8-methyl-N-(2-(methylamino)-2-oxo-1-phenylethyl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-chloro-2-fluorophenyl)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(5-chloro-2-fluorophenyl)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-chloro-4-fluorophenyl)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-3-(4-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-3-(3-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2,4-difluorophenyl)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-chloro-3-fluorophenyl)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3,4-difluorophenyl)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2,5-difluorophenyl)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(5-chloro-2,4-difluorophenyl)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-8-methyl-3-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-chloro-2-fluorophenyl)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3-chloro-4-fluorophenyl)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(5-chloro-2-fluorophenyl)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(4-chloro-3-fluorophenyl)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3,4-difluorophenyl)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2,5-difluorophenyl)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2,4-difluorophenyl)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4-methyl-1-oxopentan-2-yl)-3-(4-chloro-2-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4-methyl-1-oxopentan-2-yl)-3-(4-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4-methyl-1-oxopentan-2-yl)-3-(3-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4-methyl-1-oxopentan-2-yl)-3-(2,5-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4-methyl-1-oxopentan-2-yl)-3-(2,4-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4-methyl-1-oxopentan-2-yl)-3-(5-chloro-2-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4-methyl-1-oxopentan-2-yl)-3-cyclohexyl-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4-methyl-1-oxopentan-2-yl)-3-(5-chloro-2,4-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4-methyl-1-oxopentan-2-yl)-8-methyl-3-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(4-chloro-2-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(5-chloro-2-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(2,5-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(3-chloro-4-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(4-chloro-3-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(2,4-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-3-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(5-chloro-2,4-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide; (S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(3,4-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4,4-dimethyl-1-oxopentan-2-yl)-3-(2,5-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4,4-dimethyl-1-oxopentan-2-yl)-3-(4-chloro-2-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4,4-dimethyl-1-oxopentan-2-yl)-3-(5-chloro-2-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4,4-dimethyl-1-oxopentan-2-yl)-3-(3,4-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4,4-dimethyl-1-oxopentan-2-yl)-3-(3-chloro-4-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4,4-dimethyl-1-oxopentan-2-yl)-3-(4-chloro-3-fluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4,4-dimethyl-1-oxopentan-2-yl)-3-(2,4-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4,4-dimethyl-1-oxopentan-2-yl)-8-methyl-3-(2,4,5-trifluoro-phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(1-amino-4,4-dimethyl-1-oxopentan-2-yl)-3-(5-chloro-2,4-difluorophenyl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-8-methyl-N-(1-(methylamino)-1-oxo-3-(thiazol-4-yl)propan-2-yl)-3-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(5-chloro-2,4-difluorophenyl)-8-methyl-N-(1-(methylamino)-1-oxo-3-(thiazol-4-yl)propan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-3-(3,6-dihydro-2H-pyran-4-yl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

N-(5-tert-butylisoxazol-3-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

N-(4-tert-butylthiazol-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-chloro-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-chloro-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(3,5-bis(trifluoromethyl)phenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carboxamide;

(S)-3-(4-bromo-2-fluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-3-(2,6-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide

(S)-N-methyl-1-(3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carbonyl)pyrrolidine-2-carboxamide;

(S)-N-methyl-1-(8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]-diazepine-1-carbonyl)pyrrolidine-2-carboxamide;

N-(3-fluoro-3-methyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

N-(3-fluoro-3-methyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide;

(S)-N-(3-hydroxy-3-methyl-1-(methylamino)-1-oxobutan-2-yl)-3-phenyl-6 ,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide; and

(S)-N-(3-hydroxy-3-methyl-1-(methylamino)-1-oxobutan-2-yl)-8-methyl-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide.

Assignments (2)

CHANGE OF ADDRESS Recorded Apr 9, 2024

From: CARA THERAPEUTICS, INC.

To: CARA THERAPEUTICS, INC.

Reel/Frame 067070/0643 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 20, 2008

From: BECKETT, R. PAUL; FOSTER, RICHARD; HENAULT, CHRISTELLE; RALBOVSKY, JANET L.; GAUSS, CARLA M.; GUSTAFSON, GARY R.; LUO, ZHIYONG; CAMPBELL, ANN-MARIE; SHELEKHIN, TATIANA E.

To: CARA THERAPEUTICS, INC.

Reel/Frame 021125/0281 →

Continuity (4)

Provisional Application 6093675400 · Jun 21, 2007

Provisional Application 6099442200 · Sep 19, 2007

Provisional Application 6100839500 · Dec 19, 2007

Related Publication 20080318935A1 · Dec 25, 2008