Activation of bone and cartilage formation
View Patent ↗Provided is a method of activating osteogenic or chondrogenic activity at a site in a subject in need thereof. Also provided is a method of treating a bone or cartilage defect in a subject. Additionally, the use of a reduced pressure apparatus for treating a bone or cartilage defect adjacent to dura mater, periosteum, or endosteum is provided. Further provided is a composition for treating a bone or cartilage defect. Also, the use of a reduced pressure apparatus and a biocompatible scaffold for the manufacture of a composition for treating a bone or cartilage defect adjacent to dura mater, periosteum or endosteum is provided.
1. A method of activating osteogenic or chondrogenic activity at a tissue site in a subject, the method comprising applying reduced pressure to a dura mater, of the subject adjacent the tissue site in the subject.
2. The method of claim 1 , wherein the tissue site is a bone or cartilage defect adjacent to the dura mater.
3. The method of claim 2 , wherein the defect is (a) from a wound, (b) due to cancer, (c) due to a degenerative disease, or (d) congenital.
4. The method of claim 2 , wherein a biocompatible scaffold is inserted into the defect.
5. The method of claim 4 , wherein the biocompatible scaffold is a bioresorbable polymer.
6. The method of claim 5 , wherein the bioresorbable polymer is a polylactide-coglycolide (PLAGA) polymer or a polyethylene glycol-PLAGA copolymer.
7. The method of claim 2 , wherein the reduced pressure is applied to the defect through a manifold connected to a reduced pressure source, wherein the manifold is porous and is placed on or in the defect.
8. The method of claim 7 , wherein the manifold is from a flowable material that is delivered through a manifold delivery tube to the tissue site such that the flowable material fills the defect.
9. The method of claim 7 , wherein the manifold is a bioresorbable polymer and is capable of serving a biocompatible scaffold.
10. The method of claim 1 , wherein the reduced pressure induces endosteum osteogenic activity.
11. The method of claim 1 , wherein the reduced pressure is applied for a period of time between about 12 hours and about 3 days.
12. A method of treating a bone or cartilage defect in a subject, the method comprising applying reduced pressure to the dura mater that is adjacent to the defect.
13. The method of claim 12 , wherein a biocompatible scaffold is inserted into the defect.
14. The method of claim 13 , wherein the biocompatible scaffold is a bioresorbable polymer.
15. The method of claim 14 , wherein the bioresorbable polymer is a polylactide-coglycolide (PLAGA) polymer or a polyethylene glycol-PLAGA copolymer.
16. The method of claim 12 , wherein the reduced pressure is applied to the dura mater through a manifold connected to a reduced pressure source, wherein the manifold is porous and is placed on or in the defect.
17. The method of claim 16 , wherein the manifold comprises a bioresorbable polymer and is capable of serving as a biocompatible scaffold.