IP Library Granted Patent US 8,435,461
Granted Patent B2
US 8,435,461 · App. 12/148,344 · Granted May 7, 2013

Analytical devices with integrated desiccant

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Quick Facts
Patent No.
US 8,435,461
App. No.
12/148,344
Granted
May 7, 2013
Kind
B2
Abstract

An analytical device for performing an assay to determine the presence or approximate quantity of at least one analyte in a liquid sample is described. The device is manufactured to include an integrated desiccant within at least a test strip of the device. Addition of an integrated desiccant within the device improves signal to noise ratio, eases the manufacturing process, and saves in cost of production of the device.

Claims (14)

1. A lateral flow immunoassay device for detection of an analyte in a biological sample, comprising:

an analytical test strip comprising

a support member,

a plurality of porous pads in fluid communication, said plurality of porous pads in contact with the support member and including, in sequence, a sample receiving pad, a label pad containing mobile tag reagents, a test pad containing immobilized binding reagents, and an absorbent pad which serves as a sink zone, and

a desiccant portion, comprising a film or membrane having desiccant dispersed therein, which is laminated to the analytical test strip, such that said desiccant is disposed adjacent but not in contact with the absorbent pad,

wherein said desiccant portion remains integral with the analytical test strip during use thereof.

2. The device of claim 1 , wherein the desiccant portion comprises a material selected from the group consisting of molecular sieves and silica gel.

3. The device of claim 1 , wherein the analytical test strip is in the form of a dipstick.

4. The device of claim 1 , wherein said mobile tag reagents and immobilized reagents are capable of binding an influenza A analyte.

5. The device of claim 4 , comprising two test lines within said test pad, containing immobilized reagents capable of binding influenza A and influenza B analytes, respectively.

6. The device of claim 1 , wherein said mobile tag reagents and immobilized reagents are capable of binding a Streptococcus pyogenes analyte.

7. The device of claim 1 , wherein the desiccant is integrated into the device by

(i) providing a desiccant-loaded film or membrane; and

(ii) laminating said desiccant-loaded film or membrane to the test strip.

Assignments (9)
RELEASE (REEL 060220 / FRAME 0711) Recorded Aug 22, 2025
From: BANK OF AMERICA, N.A.
To: QUIDEL CORPORATION; BIOHELIX CORPORATION; DIAGNOSTIC HYBRIDS, INC.; QUIDEL CARDIOVASCULAR INC.; ORTHO-CLINICAL DIAGNOSTICS, INC.; CRIMSON U.S. ASSETS LLC; CRIMSON INTERNATIONAL ASSETS LLC; MICRO TYPING SYSTEMS, INC.
Reel/Frame 072577/0536 →
SECURITY AGREEMENT Recorded Aug 22, 2025
From: CRIMSON INTERNATIONAL ASSETS LLC; MICRO TYPING SYSTEMS, INC.; ORTHO-CLINICAL DIAGNOSTICS, INC.; QUIDEL CARDIOVASCULAR INC.
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 072526/0643 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 15, 2024
From: QUIDEL CORPORATION
To: ORTHO-CLINICAL DIAGNOSTICS, INC.
Reel/Frame 068657/0827 →
RELEASE OF SECURITY INTEREST Recorded May 31, 2022
From: BANK OF AMERICA, N.A.
To: QUIDEL CORPORATION
Reel/Frame 060220/0649 →
SECURITY AGREEMENT Recorded May 31, 2022
From: QUIDEL CORPORATION; BIOHELIX CORPORATION; DIAGNOSTIC HYBRIDS, INC.; QUIDEL CARDIOVASCULAR INC.; ORTHO-CLINICAL DIAGNOSTICS, INC.; CRIMSON U.S. ASSETS LLC; CRIMSON INTERNATIONAL ASSETS LLC; MICRO TYPING SYSTEMS, INC.
To: BANK OF AMERICA, N.A.
Reel/Frame 060220/0711 →
SECURITY INTEREST Recorded Oct 6, 2017
From: QUIDEL CORPORATION
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 044141/0686 →
NOTICE OF RELEASE OF GRANT OF PATENT SECURITY INTEREST Recorded Dec 1, 2016
From: BANK OF AMERICA, N.A., AS AGENT
To: QUIDEL CORPORATION
Reel/Frame 040789/0891 →
GRANT OF PATENT SECURITY INTEREST Recorded Oct 10, 2008
From: QUIDEL CORPORATION
To: BANK OF AMERICA, N.A., AS AGENT
Reel/Frame 021658/0855 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 26, 2008
From: KIRBY, KEVIN J.; DENNISON, SARAH
To: QUIDEL CORPORATION
Reel/Frame 021441/0349 →