Intracellular domain of a mammalian Fat1 (Fat1IC)
View Patent ↗Provided is an extracellular domain of a mammalian Fat1 (Fat1 EC ). Also provided is an intracellular domain of a mammalian Fat1 (Fat1 IC ). Additionally provided is a vector comprising a nucleic acid sequence encoding the Fat1 EC . A vector comprising a nucleic acid sequence encoding the Fat1 IC is further provided. Also, a vascular stent coated with the Fat1 EC is provided. Further provided is a vascular stent coated with a Fat1 ligand that activates Fat1. A method of treating a patient at risk for restenosis of a blood vessel is additionally provided. Further, methods of treating an injured blood vessel in a patient is provided. A method of treating a patient at risk for restenosis of a blood vessel or having an injured blood vessel is also provided.
1. A method of inhibiting vascular smooth muscle cell (VSMC) proliferation in a patient having a bypass surgery vascular repair or an angioplasty vascular repair, the method comprising administering to the patient having the vascular repair an amount of a fusion protein consisting essentially of the sequence of residues 4202-4588 of SEQ ID NO:2 fused to the amino acid sequence of an extracellular domain and transmembrane region of an interleukin 2 receptor α-chain which localizes to a cell membrane effective to inhibit (VSMC) proliferation.
2. The method of claim 1 , wherein the vascular repair is an angioplasty vascular repair.
3. The method of claim 1 , wherein the patient is at risk of restenosis.
4. The method of claim 1 , wherein the vascular repair is a bypass surgery vascular repair.
5. The method of claim 1 , wherein the vascular repair is of a coronary artery.